monitoring-blood-brain-barrier-opening-rats-with-preclinical-focused

Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System

The brain has a highly selective semipermeable blood barrier, termed the blood-brain barrier (BBB), which prevents the delivery of therapeutic ...

University of California, San Francisco

Kyung Hee University

In magnetic resonance (MR)-guided thermal therapy, respiratory motion can cause a significant temperature error in MR thermometry and reduce the efficiency of the treatment. A respiratory motion simulator is necessary for the development of new MR imaging (MRI) and motion compensation techniques.

Technical note: Low-cost MR-compatible pneumatic respiratory organ motion simulator for the development of MR-guided thermal therapy.

T2-weighted Single Shot Fast Spin Echo (SSFSE) scans at 3 Tesla (3T) are increasingly used to image fetal pathology due to their excellent tissue contrast resolution and signal-to-noise ratio (SNR). Temperature changes that may occur in response to radio frequency (RF) pulses used for these sequences at 3T have not been studied in human fetal brains. To evaluate the safety of T2-weighted SSFSE for fetal brains at 3T, magnetic resonance (MR) thermometry was used to measure relative temperature changes in a typical clinical fetal brain MR exam.

Estimate of fetal brain temperature using proton resonance frequency thermometry during 3 Tesla fetal magnetic resonance imaging.

Interest in transcranial MR imaging-guided focused ultrasound procedures has recently grown. These incisionless procedures enable precise focal ablation of brain tissue using real-time monitoring by MR thermometry. This article will provide an updated review on clinically applicable technical underpinnings and considerations of proton resonance frequency MR thermometry, the most common clinically used MR thermometry sequence.

Article	Year
Technical note: Low-cost MR-compatible pneumatic respiratory organ motion simulator for the development of MR-guided thermal therapy. Medical physics\| PubMed ID: 35635215	2022
Estimate of fetal brain temperature using proton resonance frequency thermometry during 3 Tesla fetal magnetic resonance imaging. Quantitative imaging in medicine and surgery\| PubMed ID: 38106288	2023
MR Thermometry during Transcranial MR Imaging-Guided Focused Ultrasound Procedures: A Review. AJNR. American journal of neuroradiology\| PubMed ID: 38123912	2023

Kisoo Kim

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