Nahum Sonenberg

Rosalind and Morris Goodman Cancer Institute, McGill University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2024

Other Publications

Article	Year
Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells. Gene expression\| PubMed ID: 7787416	1995
Remarks on the mechanism of ribosome binding to eukaryotic mRNAs. Gene expression\| PubMed ID: 8019130	1993
Weak binding affinity of human 4EHP for mRNA cap analogs. RNA (New York, N.Y.)\| PubMed ID: 17369309	2007
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell\| PubMed ID: 17418795	2007
Reconstitution reveals the functional core of mammalian eIF3. The EMBO journal\| PubMed ID: 17581632	2007
Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation? Journal of virology\| PubMed ID: 17855553	2007
Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP). RNA (New York, N.Y.)\| PubMed ID: 17942745	2007
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. The EMBO journal\| PubMed ID: 17962806	2007
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. Journal of virology\| PubMed ID: 18417567	2008
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA (New York, N.Y.)\| PubMed ID: 18515545	2008
The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Molecular biology of the cell\| PubMed ID: 18653466	2008
Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Molecular and cellular biology\| PubMed ID: 18725400	2008
General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. The EMBO journal\| PubMed ID: 19078965	2009
Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Molecular and cellular biology\| PubMed ID: 19114555	2009
Translational control of long-lasting synaptic plasticity and memory. Neuron\| PubMed ID: 19146809	2009
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell\| PubMed ID: 19203580	2009
Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell\| PubMed ID: 19239892	2009
Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference. PloS one\| PubMed ID: 19290046	2009
Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19403827	2009
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Molecular cell\| PubMed ID: 19716330	2009
Novel translational control in Arc-dependent long term potentiation consolidation in vivo. The Journal of biological chemistry\| PubMed ID: 19755425	2009
Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19851022	2009
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018725	2009
Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 20057060	2010
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080710	2010
Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Molecular and cellular biology\| PubMed ID: 20086100	2010
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nature structural & molecular biology\| PubMed ID: 20098421	2010
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell\| PubMed ID: 20144759	2010
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 20145189	2010
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Molecular cell\| PubMed ID: 20347422	2010
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic acids research\| PubMed ID: 20413581	2010
Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. The Journal of biological chemistry\| PubMed ID: 20424163	2010
A collection of caged compounds for probing roles of local translation in neurobiology. Bioorganic & medicinal chemistry\| PubMed ID: 20427189	2010
S6K1 plays a critical role in early adipocyte differentiation. Developmental cell\| PubMed ID: 20493810	2010
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (New York, N.Y.)\| PubMed ID: 20508131	2010
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. The Journal of clinical investigation\| PubMed ID: 20644257	2010
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20679199	2010
Translational control mechanisms in long-lasting synaptic plasticity and memory. The Journal of biological chemistry\| PubMed ID: 20693284	2010
The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. The Journal of clinical investigation\| PubMed ID: 20739757	2010
eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20948310	2010
Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families. Molecular cell\| PubMed ID: 21095586	2010
Identification of differential translation in genome wide studies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21115840	2010
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Human molecular genetics\| PubMed ID: 21118894	2011
anota: Analysis of differential translation in genome-wide studies. Bioinformatics (Oxford, England)\| PubMed ID: 21422072	2011
mRNA helicases: the tacticians of translational control. Nature reviews. Molecular cell biology\| PubMed ID: 21427765	2011
Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. EMBO reports\| PubMed ID: 21475248	2011
Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell host & microbe\| PubMed ID: 21501832	2011
An efficient system for let-7 microRNA and GW182 protein-mediated deadenylation in vitro. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21528456	2011
Translational control by the eukaryotic ribosome. Cell\| PubMed ID: 21529706	2011
Unique translation initiation of mRNAs-containing TISU element. Nucleic acids research\| PubMed ID: 21705780	2011
Translation initiator EIF4G1 mutations in familial Parkinson disease. American journal of human genetics\| PubMed ID: 21907011	2011
Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular pain\| PubMed ID: 21936900	2011
Cap and cap-binding proteins in the control of gene expression. Wiley interdisciplinary reviews. RNA\| PubMed ID: 21957010	2011
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nature structural & molecular biology\| PubMed ID: 21984185	2011
Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22006312	2011
Functional and direct interaction between the RNA binding protein HuD and active Akt1. Nucleic acids research\| PubMed ID: 22075994	2012
PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Biology of reproduction\| PubMed ID: 22190698	2012
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. PLoS pathogens\| PubMed ID: 22194691	2011
Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The EMBO journal\| PubMed ID: 22307088	2012
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic acids research\| PubMed ID: 22362743	2012
Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions. Biophysical journal\| PubMed ID: 22455926	2012
The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic acids research\| PubMed ID: 22457067	2012
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. The Journal of biological chemistry\| PubMed ID: 22474287	2012
TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron\| PubMed ID: 22500638	2012
Regulation of Neuronal mRNA Translation by CaM-Kinase I Phosphorylation of eIF4GII. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22514323	2012
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nature immunology\| PubMed ID: 22544393	2012
Translational homeostasis via the mRNA cap-binding protein, eIF4E. Molecular cell\| PubMed ID: 22578813	2012
Distinct perturbation of the translatome by the antidiabetic drug metformin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22611195	2012
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nature structural & molecular biology\| PubMed ID: 22664986	2012
The Distribution of eIF4E-Family Members across Insecta. Comparative and functional genomics\| PubMed ID: 22745595	2012
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Molecular and cellular biology\| PubMed ID: 22751931	2012
Retrospective. Aaron Shatkin (1934-2012). Science (New York, N.Y.)\| PubMed ID: 22822142	2012
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (Cambridge, England)\| PubMed ID: 22833128	2012
Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The EMBO journal\| PubMed ID: 22850669	2012
Host translation at the nexus of infection and immunity. Cell host & microbe\| PubMed ID: 23084916	2012
Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature\| PubMed ID: 23172145	2013
Toward a genome-wide landscape of translational control. Cold Spring Harbor perspectives in biology\| PubMed ID: 23209130	2013
Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23365227	2013
Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23392680	2013
The mTOR pathway in hepatic malignancies. Hepatology (Baltimore, Md.)\| PubMed ID: 23408390	2013
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal perio... The Journal of biological chemistry\| PubMed ID: 23426372	2013
mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget\| PubMed ID: 23455427	2012
Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure (London, England : 1993)\| PubMed ID: 23478064	2013
Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Molecular and cellular biology\| PubMed ID: 23547259	2013
Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. Cell metabolism\| PubMed ID: 23562079	2013
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain\| PubMed ID: 23607966	2013
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and cellular biology\| PubMed ID: 23608534	2013
Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron\| PubMed ID: 23622065	2013
Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nature structural & molecular biology\| PubMed ID: 23644599	2013
Distinct translational control in CD4+ T cell subsets. PLoS genetics\| PubMed ID: 23658533	2013
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. PLoS biology\| PubMed ID: 23700384	2013
Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Molecular and cellular biology\| PubMed ID: 23716590	2013
Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife\| PubMed ID: 23741617	2013
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron\| PubMed ID: 23972597	2013
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell metabolism\| PubMed ID: 24206664	2013
Parallel measurement of dynamic changes in translation rates in single cells. Nature methods\| PubMed ID: 24213167	2014
Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Molecular and cellular biology\| PubMed ID: 24396066	2014
Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Molecular immunology\| PubMed ID: 24486724	2014
Translational control and autism-like behaviors. Cellular logistics\| PubMed ID: 24516777	2013
Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell stem cell\| PubMed ID: 24630793	2014
Largen: a molecular regulator of mammalian cell size control. Molecular cell\| PubMed ID: 24656129	2014
Remote control of gene function by local translation. Cell\| PubMed ID: 24679524	2014
Translational control of immune responses: from transcripts to translatomes. Nature immunology\| PubMed ID: 24840981	2014
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24843127	2014
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene\| PubMed ID: 24909168	2015
Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Structure (London, England : 1993)\| PubMed ID: 24909782	2014
Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1. RNA (New York, N.Y.)\| PubMed ID: 25035296	2014
Distinctive tRNA repertoires in proliferating versus differentiating cells. Cell\| PubMed ID: 25215483	2014
MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. Molecular cell\| PubMed ID: 25280105	2014
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature\| PubMed ID: 25383520	2015
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell reports\| PubMed ID: 25466251	2014
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature\| PubMed ID: 25533957	2015
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer research\| PubMed ID: 25593033	2015
Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection. Cell metabolism\| PubMed ID: 25738462	2015
Targeting the translation machinery in cancer. Nature reviews. Drug discovery\| PubMed ID: 25743081	2015
DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. Nucleic acids research\| PubMed ID: 25779044	2015
The long unfinished march towards understanding microRNA-mediated repression. RNA (New York, N.Y.)\| PubMed ID: 25780122	2015
Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing. Nature communications\| PubMed ID: 25817275	2015
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. The Journal of cell biology\| PubMed ID: 25847539	2015
Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature neuroscience\| PubMed ID: 25915475	2015
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PloS one\| PubMed ID: 25923732	2015
Translation and cancer. Biochimica et biophysica acta\| PubMed ID: 25988403	2015
Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO reports\| PubMed ID: 26113365	2015
Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26245973	2015
Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 26373828	2015
Signalling to eIF4E in cancer. Biochemical Society transactions\| PubMed ID: 26517881	2015
Translational control of nociception via 4E-binding protein 1. eLife\| PubMed ID: 26678009	2015
Introduction to Translation. Translation (Austin, Tex.)\| PubMed ID: 26824021	2013
mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Developmental neurobiology\| PubMed ID: 27008592	2016
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nature immunology\| PubMed ID: 27043414	2016
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass. Diabetes\| PubMed ID: 27217487	2016
The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Science signaling\| PubMed ID: 27245614	2016
Translational control by 5'-untranslated regions of eukaryotic mRNAs. Science (New York, N.Y.)\| PubMed ID: 27313038	2016
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. Nature communications\| PubMed ID: 27319316	2016
Diverse cap-binding properties of Drosophila eIF4E isoforms. Biochimica et biophysica acta\| PubMed ID: 27374989	2016
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nature communications\| PubMed ID: 27432119	2016
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell\| PubMed ID: 27477511	2016
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & development\| PubMed ID: 27492367	2016
Transcriptional induction of 4E-BP3 prolongs translation repression. Cell cycle (Georgetown, Tex.)\| PubMed ID: 27565030	2016
eIF2α phosphorylation controls thermal nociception. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27698114	2016
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27791185	2016
Proposing a mechanism of action for ataluren. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27791186	2016
Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism. Neuron\| PubMed ID: 27916456	2016
A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Nucleic acids research\| PubMed ID: 28204614	2017
N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic acids research\| PubMed ID: 28334758	2017
Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28484016	2017
Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28487484	2017
Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature medicine\| PubMed ID: 28504725	2017
Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity. Molecular nutrition & food research\| PubMed ID: 28544394	2017
Translational control and the cancer cell response to stress. Current opinion in cell biology\| PubMed ID: 28582681	2017
The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28674170	2017
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature communications\| PubMed ID: 28685749	2017
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature communications\| PubMed ID: 28699639	2017
Translation is actively regulated during the differentiation of CD8 effector T cells. Nature immunology\| PubMed ID: 28714979	2017
Epiregulin and EGFR interactions are involved in pain processing. The Journal of clinical investigation\| PubMed ID: 28783046	2017
Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells. Oncotarget\| PubMed ID: 28881582	2017
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Molecular cell\| PubMed ID: 28918902	2017
Fragile X syndrome. Nature reviews. Disease primers\| PubMed ID: 28960184	2017
Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29078415	2017
Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 29080206	2018
Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity. Current opinion in genetics & development\| PubMed ID: 29169064	2018
Aminoacylation of Proteins: New Targets for the Old ARSenal. Cell metabolism\| PubMed ID: 29320701	2018
Translational control of ERK signaling through miRNA/4EHP-directed silencing. eLife\| PubMed ID: 29412140	2018
The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. Molecular cancer research : MCR\| PubMed ID: 29453322	2018
Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29463754	2018
Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene\| PubMed ID: 29463861	2018
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29555746	2018
Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity. Cell reports\| PubMed ID: 29617653	2018
Neuronal Regulation of eIF2α Function in Health and Neurological Disorders. Trends in molecular medicine\| PubMed ID: 29716790	2018
Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nature communications\| PubMed ID: 29941989	2018
Translational Control in Cancer. Cold Spring Harbor perspectives in biology\| PubMed ID: 29959193	2019
Principles of Translational Control. Cold Spring Harbor perspectives in biology\| PubMed ID: 29959195	2019
Translation deregulation in human disease. Nature reviews. Molecular cell biology\| PubMed ID: 30038383	2018
Protein Synthesis and Translational Control: A Historical Perspective. Cold Spring Harbor perspectives in biology\| PubMed ID: 30082466	2019
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLoS pathogens\| PubMed ID: 30138450	2018
Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders. Annual review of medicine\| PubMed ID: 30365357	2019
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma. Nature medicine\| PubMed ID: 30374200	2018
HGF-induced migration depends on the PI(3,4,5)P-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1. The Journal of cell biology\| PubMed ID: 30404949	2019
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30459229	2019
Dynamic interaction of poly(A)-binding protein with the ribosome. Scientific reports\| PubMed ID: 30487538	2018
Translational Control in Stem Cells. Frontiers in genetics\| PubMed ID: 30697227	2018
Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30765518	2019
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer research\| PubMed ID: 30894372	2019
A threonyl-tRNA synthetase-mediated translation initiation machinery. Nature communications\| PubMed ID: 30902983	2019
Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30926667	2019
4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30927336	2019
The Organizing Principles of Eukaryotic Ribosome Recruitment. Annual review of biochemistry\| PubMed ID: 31220979	2019
Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31427534	2019
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. Science (New York, N.Y.)\| PubMed ID: 31439799	2019
V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. Oncotarget\| PubMed ID: 31452834	2019
The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Neuron\| PubMed ID: 31522764	2019
Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2. Sleep\| PubMed ID: 31553042	2020
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer. JCI insight\| PubMed ID: 31672935	2019
Role of Translational Attenuation in Inherited Retinal Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 31747684	2019
Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases. International journal of molecular sciences\| PubMed ID: 31817343	2019
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell reports\| PubMed ID: 31968247	2020
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions. Molecular cell\| PubMed ID: 31999954	2020
4E-BP-Dependent Translational Control of Mediates Adipose Tissue Macrophage Inflammatory Response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32213561	2020
The translational landscape of ground state pluripotency. Nature communications\| PubMed ID: 32238817	2020
Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR. Cell reports\| PubMed ID: 32348753	2020
Dysregulated translational control in brain disorders: from genes to behavior. Current opinion in genetics & development\| PubMed ID: 32535350	2020
Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition. Nature communications\| PubMed ID: 32561718	2020
Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer. Molecular cancer research : MCR\| PubMed ID: 32587106	2020
Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1. EMBO reports\| PubMed ID: 32648345	2020
Metformin inhibits RAN translation through PKR pathway and mitigates disease in ALS/FTD mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32690681	2020
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions. Nucleic acids research\| PubMed ID: 32766783	2020
eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature\| PubMed ID: 33029011	2020
eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. eLife\| PubMed ID: 33135632	2020
Unorthodox Mechanisms to Initiate Translation Open Novel Paths for Gene Expression. Journal of molecular biology\| PubMed ID: 33166539	2020
The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Molecular autism\| PubMed ID: 33225984	2020
The multifaceted eukaryotic cap structure. Wiley interdisciplinary reviews. RNA\| PubMed ID: 33300197	2021
MNK Inhibition Sensitizes -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression. Cancer discovery\| PubMed ID: 33328217	2021
Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature\| PubMed ID: 33328636	2021
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Molecular cell\| PubMed ID: 33340489	2021
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33495318	2021
microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP. Molecular cell\| PubMed ID: 33581076	2021
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. The Journal of clinical investigation\| PubMed ID: 33690225	2021
microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. Nucleic acids research\| PubMed ID: 33758928	2021
4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33876772	2021
4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell reports\| PubMed ID: 33910008	2021
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models. Nature communications\| PubMed ID: 34011960	2021
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation. JCI insight\| PubMed ID: 34032633	2021
Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells. Stem cell reports\| PubMed ID: 34214487	2021
Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse. Cellular and molecular life sciences : CMLS\| PubMed ID: 34559254	2021
High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34615711	2021
Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs. Nucleic acids research\| PubMed ID: 34933339	2022
UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony. Nature communications\| PubMed ID: 35332162	2022
Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8 T Cell Proliferation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 35667842	2022
Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. Cell reports\| PubMed ID: 35675781	2022
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35878012	2022
The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35994670	2022
TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with mRNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35994673	2022
Evolution of naturally arising SARS-CoV-2 defective interfering particles. Communications biology\| PubMed ID: 36302891	2022
Recollections - Dr. Yasuhiro Furuichi. RNA (New York, N.Y.)\| PubMed ID: 36617660	2022
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Molecular brain\| PubMed ID: 36650535	2023
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E. Biochemical Society transactions\| PubMed ID: 36661272	2023
Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration. Biosensors\| PubMed ID: 36832056	2023
Messenger RNA Translation Defects in Neurodegenerative Diseases. The New England journal of medicine\| PubMed ID: 36920757	2023
MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach. Frontiers in molecular biosciences\| PubMed ID: 37091863	2023
Messenger RNA Translation Defects in Neurodegenerative Diseases. Reply. The New England journal of medicine\| PubMed ID: 37256994	2023
The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 37307456	2023
Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 37454282	2023
p38γ and p38δ modulate innate immune response by regulating MEF2D activation. eLife\| PubMed ID: 37458356	2023
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron\| PubMed ID: 37473758	2023
The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression. Journal of cell science\| PubMed ID: 37732428	2023
Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis. European respiratory review : an official journal of the European Respiratory Society\| PubMed ID: 37758276	2023
mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes. Neurology. Genetics\| PubMed ID: 37900581	2023
Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 37914402	2023
4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Science advances\| PubMed ID: 37922363	2023
C8ORF88: A Novel eIF4E-Binding Protein. Genes\| PubMed ID: 38003019	2023
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 38015848	2023
Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes. Nucleic acids research\| PubMed ID: 38038264	2024
Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells. Cell reports\| PubMed ID: 38159280	2024
Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation. Molecular brain\| PubMed ID: 38858726	2024
The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 38934107	2024
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. bioRxiv : the preprint server for biology\| PubMed ID: 38979173	2024
Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Science advances\| PubMed ID: 39018414	2024
Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 39042682	2024
The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 39047038	2024
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation. Life science alliance\| PubMed ID: 39111820	2024
MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction. The Journal of clinical investigation\| PubMed ID: 39145446	2024
Microfluidic Wound-Healing Assay for Comparative Study on Fluid Dynamic, Chemical and Mechanical Wounding on Microglia BV2 Migration. Micromachines\| PubMed ID: 39203655	2024