Michael W. Traxlmayr

Department of Chemistry, BOKU University

Affiliated withBOKU University CD Laboratory for Next Generation CAR T Cells

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
Integrin binding human antibody constant domains--probing the C-terminal structural loops for grafting the RGD motif. Journal of biotechnology\| PubMed ID: 21771617	2011
Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast. Biochimica et biophysica acta\| PubMed ID: 22285845	2012
Directed evolution of proteins for increased stability and expression using yeast display. Archives of biochemistry and biophysics\| PubMed ID: 22575387	2012
Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing. Journal of molecular biology\| PubMed ID: 22846908	2012
Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display. Protein engineering, design & selection : PEDS\| PubMed ID: 23267121	2013
Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc. Protein engineering, design & selection : PEDS\| PubMed ID: 24006374	2013
Creating stable stem regions for loop elongation in Fcabs - insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations. Biochimica et biophysica acta\| PubMed ID: 24792385	2014
Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution. Biotechnology journal\| PubMed ID: 24964247	2014
Engineered IgG1-Fc--one fragment to bind them all. Immunological reviews\| PubMed ID: 26864108	2016
Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library. The Journal of biological chemistry\| PubMed ID: 27582495	2016
Directed Evolution of Protein Thermal Stability Using Yeast Surface Display. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28255874	2017
Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies. Structure (London, England : 1993)\| PubMed ID: 28528777	2017
Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex. mAbs\| PubMed ID: 28816592	2017
A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32554495	2020
Driving CARs with alternative navigation tools - the potential of engineered binding scaffolds. The FEBS journal\| PubMed ID: 32794303	2021
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nature communications\| PubMed ID: 32820173	2020
Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. ACS synthetic biology\| PubMed ID: 33843201	2021
PhosphoFlowSeq - A High-throughput Kinase Activity Assay for Screening Drug Resistance Mutations in EGFR. Journal of molecular biology\| PubMed ID: 34499921	2021
Affinity and Stability Analysis of Yeast Displayed Proteins. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35482190	2022
Solving the mystery of the FMC63-CD19 affinity. Scientific reports\| PubMed ID: 38155191	2023
An engineering strategy to target activated EGFR with CAR T cells. Cell reports methods\| PubMed ID: 38492569	2024
Small molecule-regulated switches to provide functional control of CAR T cells within the patient. Expert opinion on biological therapy\| PubMed ID: 38943466	2024
Protocol for engineering binding domains to recognize ligand-bound receptors by using yeast surface display. STAR protocols\| PubMed ID: 39321026	2024