less-invasive-technique-for-non-stabilized-mandibular-fracture-mouse

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Non-stabilized fractures can be made at mandibular sites in mice, thus making it possible to analyze bone repair using an endochondral ossification mode. ...

a-standardized-surgical-technique-for-tessier-medial-transnasal

A Standardized Surgical Technique for Tessier Medial Transnasal Canthopexy

Medial canthopexy is a surgical technique that allows correction of the position of the medial canthus, corresponding to the medial angle of the palpebral ...

Université de Paris Cité

Université de Tours

Hypochondroplasia (HCH) is a mild dwarfism caused by missense mutations in fibroblast growth factor receptor 3 (FGFR3), with the majority of cases resulting from a heterozygous p.Asn540Lys gain-of-function mutation. Here, we report the generation and characterization of the first mouse model (Fgfr3Asn534Lys/+) of HCH to our knowledge. Fgfr3Asn534Lys/+ mice exhibited progressive dwarfism and impairment of the synchondroses of the cranial base, resulting in defective formation of the foramen magnum. The appendicular and axial skeletons were both severely affected and we demonstrated an important role of FGFR3 in regulation of cortical and trabecular bone structure. Trabecular bone mineral density (BMD) of long bones and vertebral bodies was decreased, but cortical BMD increased with age in both tibiae and femurs. These results demonstrate that bones in Fgfr3Asn534Lys/+ mice, due to FGFR3 activation, exhibit some characteristics of osteoporosis. The present findings emphasize the detrimental effect of gain-of-function mutations in the Fgfr3 gene on long bone modeling during both developmental and aging processes, with potential implications for the management of elderly patients with hypochondroplasia and osteoporosis.

Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.

Primary osteomyelitis of the mandibular condyle is exceptionally rare. The case of a 5-month-old infant with primary osteomyelitis of the condyle, who was followed up over 6 years and avoided the devastating sequelae of temporomandibular joint ankylosis and mandibular growth impairment, is reported here. The patient presented with acute swelling, fever, and trismus, leading to the diagnosis of acute primary osteomyelitis through clinical and radiological findings. This was treated successfully with a minor surgical intervention and antibiotics. The reported case, in combination with a literature review, underscores the importance of early, multimodal diagnosis and appropriate treatment in primary osteomyelitis of the mandibular condyle in infants, highlighting the potential for favourable outcomes even in severe cases. This report contributes to the scarce literature on the subject and offers recommendations for follow-up care to help prevent long-term complications.

ArticleTotal : 2	Year
Publication title	2024
Publication title	2026

Article	Year
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice. JCI insight\| PubMed ID: 37345656	2023
Long-term outcomes after primary osteomyelitis of the mandibular condyle occurring in early infancy: a case report and literature review. International journal of oral and maxillofacial surgery\| PubMed ID: 40413140	2025

Anne Morice

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