equine-enteric-glial-culture-application-to-study-neural-inflammatory

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic

Inflammatory postoperative conditions of equine colic (acute abdomen) contribute not only to increased client cost, patient discomfort, and ...

NC State University

Previously, it was shown that the chloride channel ClC-2 modulates intestinal tight junction (TJ) barrier function. The aim of the present study was to investigate the role of ClC-2 in epithelial barrier function and recovery in the event of epithelial injury.

Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis.

Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings. Future studies to examine mechanisms underlying this link between early life adversity and functional gastrointestinal disorders will explore the roles of gender and hypomaturity in gastrointestinal responses to stress.

Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress.

Sucralfate is a gastroprotectant with no known systemic effects. The efficacy of sucralfate for prevention and treatment of stress-related mucosal diseases (SRMD) in dogs is unknown.

Article	Year
Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis. Inflammatory bowel diseases\| PubMed ID: 24030525	2013
Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress. Neurogastroenterology and motility\| PubMed ID: 29052972	2017
Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs. Journal of veterinary internal medicine\| PubMed ID: 29460464	2018

Anthony Blikslager

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