Brian K. Kennedy

Department of Biochemistry, University of Washington

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 167	2009

Other Publications

Article	Year
Mammalian transcription factors in yeast: strangers in a familiar land. Nature reviews. Molecular cell biology\| PubMed ID: 11823797	2002
LMNA mutations in atypical Werner's syndrome. Lancet\| PubMed ID: 12927431	2003
Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Molecular and cellular biology\| PubMed ID: 14701733	2004
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15210943	2004
Sir2-independent life span extension by calorie restriction in yeast. PLoS biology\| PubMed ID: 15328540	2004
Large-scale identification in yeast of conserved ageing genes. Mechanisms of ageing and development\| PubMed ID: 15610758	2005
Substrate-specific activation of sirtuins by resveratrol. The Journal of biological chemistry\| PubMed ID: 15684413	2005
A-type nuclear lamins, progerias and other degenerative disorders. Mechanisms of ageing and development\| PubMed ID: 15722103	2005
Genes determining yeast replicative life span in a long-lived genetic background. Mechanisms of ageing and development\| PubMed ID: 15722108	2005
LMNA mutations in progeroid syndromes. Novartis Foundation symposium\| PubMed ID: 15773755	2005
Nuclear tumor suppressors in space and time. Trends in cell biology\| PubMed ID: 15936946	2005
HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. AIDS (London, England)\| PubMed ID: 16184025	2005
The enigmatic role of Sir2 in aging. Cell\| PubMed ID: 16286003	2005
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (New York, N.Y.)\| PubMed ID: 16293764	2005
Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS genetics\| PubMed ID: 16311627	2005
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes & development\| PubMed ID: 16418483	2006
Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes & development\| PubMed ID: 16481476	2006
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (New York, N.Y.)\| PubMed ID: 16741098	2006
Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Molecular and cellular biology\| PubMed ID: 16809772	2006
Sirtuins in aging and age-related disease. Cell\| PubMed ID: 16873059	2006
Aging: progeria and the lamin connection. Current biology : CB\| PubMed ID: 16920618	2006
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging cell\| PubMed ID: 17081160	2006
Genome-wide identification of conserved longevity genes in yeast and worms. Mechanisms of ageing and development\| PubMed ID: 17126379	2007
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging cell\| PubMed ID: 17129213	2006
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics\| PubMed ID: 17151231	2007
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nature reviews. Molecular cell biology\| PubMed ID: 17450177	2007
Recent developments in yeast aging. PLoS genetics\| PubMed ID: 17530929	2007
Does resveratrol activate yeast Sir2 in vivo? Aging cell\| PubMed ID: 17635418	2007
Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. PloS one\| PubMed ID: 17896003	2007
Protein translation, 2007. Aging cell\| PubMed ID: 17941970	2007
Single-gene deletions that restore mating competence to diploid yeast. FEMS yeast research\| PubMed ID: 17995956	2008
A method for high-throughput quantitative analysis of yeast chronological life span. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 18314444	2008
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging cell\| PubMed ID: 18331616	2008
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome research\| PubMed ID: 18340043	2008
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell\| PubMed ID: 18423200	2008
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC developmental biology\| PubMed ID: 18457595	2008
Protein translation, 2008. Aging cell\| PubMed ID: 18782345	2008
Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Molecular biology of the cell\| PubMed ID: 18843043	2008
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PloS one\| PubMed ID: 19030232	2008
A-type nuclear lamins act as transcriptional repressors when targeted to promoters. Experimental cell research\| PubMed ID: 19272320	2009
A molecular mechanism of chronological aging in yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19305133	2009
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature\| PubMed ID: 19516333	2009
The TOR pathway comes of age. Biochimica et biophysica acta\| PubMed ID: 19539012	2009
Ageing: A midlife longevity drug? Nature\| PubMed ID: 19606132	2009
Hot topics in aging research: protein translation, 2009. Aging cell\| PubMed ID: 19747234	2009
Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V. Biophysical journal\| PubMed ID: 19751676	2009
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 19776218	2009
Translate this ... during dietary restriction. Cell metabolism\| PubMed ID: 19808017	2009
Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. PloS one\| PubMed ID: 20405040	2010
Progeria syndromes and ageing: what is the connection? Nature reviews. Molecular cell biology\| PubMed ID: 20651707	2010
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging cell\| PubMed ID: 20726853	2010
Old yeast can't handle the noise. Molecular cell\| PubMed ID: 20832716	2010
TOR on the brain. Experimental gerontology\| PubMed ID: 20849946	2011
TOR and ageing: a complex pathway for a complex process. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 21115526	2011
Hot topics in aging research: protein translation and TOR signaling, 2010. Aging cell\| PubMed ID: 21176090	2011
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21191185	2011
Asymmetric segregation: the shape of things to come? Current biology : CB\| PubMed ID: 21334292	2011
A genomic analysis of chronological longevity factors in budding yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21447998	2011
Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1. PloS one\| PubMed ID: 21603621	2011
Trinations aging symposium. Mechanisms of ageing and development\| PubMed ID: 21771608	2011
Aged worms erase epigenetic history. Cell metabolism\| PubMed ID: 21803283	2011
Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging cell\| PubMed ID: 21902802	2011
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS genetics\| PubMed ID: 21931558	2011
Genome-wide analysis of yeast aging. Sub-cellular biochemistry\| PubMed ID: 22094426	2012
The Buck Institute: An inside look. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22157188	2011
A new chronological survival assay in mammalian cell culture. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22214665	2012