Paul Kievit

Division of Metabolic Health and Disease, Oregon National Primate Research Center

Affiliated withOregon National Primate Research Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20570821	2010
Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22739105	2012
Energizing the mind and body. Diabetes\| PubMed ID: 22923647	2012
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes\| PubMed ID: 23048186	2013
Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta). International journal of obesity (2005)\| PubMed ID: 23736354	2014
Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24048859	2013
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques. Molecular metabolism\| PubMed ID: 24049738	2013
Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insuli... Circulation\| PubMed ID: 24163066	2014
The nonhuman primate as a model for type 2 diabetes. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 24569549	2014
Preliminary Examination of Olanzapine and Diet Interactions On Metabolism in a Female Macaque. Journal of endocrinology and diabetes\| PubMed ID: 25621305	2014
Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring. Obesity (Silver Spring, Md.)\| PubMed ID: 26530932	2015
Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance. Diabetes\| PubMed ID: 27207517	2016
Vasoconstrictor eicosanoids and impaired microvascular function in inactive and insulin-resistant primates. International journal of obesity (2005)\| PubMed ID: 27357159	2016
Perpetuating effects of androgen deficiency on insulin resistance. International journal of obesity (2005)\| PubMed ID: 27534842	2016
Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic melanocortin signaling in nonhuman primate offspring. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 28404581	2017
Arcuate nucleus neuropeptide coexpression and connections to gonadotrophin-releasing hormone neurones in the female rhesus macaque. Journal of neuroendocrinology\| PubMed ID: 28561903	2017
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes. Nature communications\| PubMed ID: 29127275	2017
Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field. ILAR journal\| PubMed ID: 29216341	2017
Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates. BMC microbiology\| PubMed ID: 29621980	2018
Maternal Diet, Metabolic State, and Inflammatory Response Exert Unique and Long-Lasting Influences on Offspring Behavior in Non-Human Primates. Frontiers in endocrinology\| PubMed ID: 29740395	2018
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys. International journal of obesity (2005)\| PubMed ID: 29892039	2018
Maternal High-Fat Diet Effects on Adaptations to Metabolic Challenges in Male and Female Juvenile Nonhuman Primates. Obesity (Silver Spring, Md.)\| PubMed ID: 30226008	2018
Early High-Fat Diet Exposure Causes Dysregulation of the Orexin and Dopamine Neuronal Populations in Nonhuman Primates. Frontiers in endocrinology\| PubMed ID: 30258403	2018
Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Molecular metabolism\| PubMed ID: 30337225	2018
Estradiol Replacement Timing and Obesogenic Diet Effects on Body Composition and Metabolism in Postmenopausal Macaques. Endocrinology\| PubMed ID: 30753523	2019
A Long-Acting PYY Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates. Cell metabolism\| PubMed ID: 30773465	2019
Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons. Physiology & behavior\| PubMed ID: 30951750	2019
Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition. Molecular metabolism\| PubMed ID: 31036449	2019
Central and Peripheral Administration of Fibroblast Growth Factor 1 Improves Pancreatic Islet Insulin Secretion in Diabetic Mouse Models. Diabetes\| PubMed ID: 31048370	2019
The development and ecology of the Japanese macaque gut microbiome from weaning to early adolescence in association with diet. American journal of primatology\| PubMed ID: 31066111	2019
Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons. Molecular metabolism\| PubMed ID: 31230943	2019
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Science translational medicine\| PubMed ID: 31578240	2019
Effects of pre- and postnatal protein restriction on maternal and offspring metabolism in the nonhuman primate. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 32130027	2020
Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes\| PubMed ID: 32354857	2020
Palmitic Acid Targets Human Testicular Peritubular Cells and Causes a Pro-Inflammatory Response. Journal of clinical medicine\| PubMed ID: 32824411	2020
Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors. The Journal of biological chemistry\| PubMed ID: 33037073	2020
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell reports\| PubMed ID: 33113371	2020
Short-term Western-style diet negatively impacts reproductive outcomes in primates. JCI insight\| PubMed ID: 33616080	2021
Arterial Platelet Adhesion in Atherosclerosis-Prone Arteries of Obese, Insulin-Resistant Nonhuman Primates. Journal of the American Heart Association\| PubMed ID: 33880941	2021
Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations. eLife\| PubMed ID: 34018926	2021
Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model. Scientific reports\| PubMed ID: 34155315	2021
Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring. JCI insight\| PubMed ID: 34935645	2021
Fibroblast Growth Factor-1 Activates Neurons in the Arcuate Nucleus and Dorsal Vagal Complex. Frontiers in endocrinology\| PubMed ID: 34987476	2021
Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers. Journal of developmental origins of health and disease\| PubMed ID: 35068408	2022
Bedding as an Enrichment Strategy in Group-housed Mauritian Cynomolgus Macaques (). Journal of the American Association for Laboratory Animal Science : JAALAS\| PubMed ID: 35140008	2022
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion . Cellular and molecular bioengineering\| PubMed ID: 35611166	2022
Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity. Blood advances\| PubMed ID: 36219587	2023
Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring. Hepatology communications\| PubMed ID: 36691970	2023
Glial, Neuronal, Vascular, Retinal Pigment Epithelium, and Inflammatory Cell Damage in a New Western Diet-Induced Primate Model of Diabetic Retinopathy. The American journal of pathology\| PubMed ID: 36965774	2023
Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring. Cell reports\| PubMed ID: 37058409	2023
Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 37134140	2023
Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nature biotechnology\| PubMed ID: 37156915	2024
Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes. Diabetes\| PubMed ID: 37347736	2023
Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models. The Journal of clinical investigation\| PubMed ID: 37581939	2023
A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques. Diabetes\| PubMed ID: 37725952	2023
Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia. Research and practice in thrombosis and haemostasis\| PubMed ID: 38226339	2024
Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model. American journal of obstetrics and gynecology\| PubMed ID: 38871238	2024
Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development. Frontiers in endocrinology\| PubMed ID: 39114287	2024
Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates. JCI insight\| PubMed ID: 39115937	2024