Roland K.O. Sigel

Department of Chemistry, University of Zurich

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif. Nature structural & molecular biology\| PubMed ID: 14745440	2004
Acid-base and metal-ion binding properties of the RNA dinucleotide uridylyl-(5'-->3')-[5']uridylate (pUpU3-). Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 15861476	2005
Acid-base properties of the nucleic-acid model 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate, d(pGpG)3-, and of related guanine derivatives. Organic & biomolecular chemistry\| PubMed ID: 16525552	2006
Metal-ion-coordinating properties of the dinucleotide 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate (d(pGpG)3-): isomeric equilibria including macrochelated complexes relevant for nucleic ... Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17121397	2007
Solution structure of domain 6 from a self-splicing group II intron ribozyme: a Mg(2+) binding site is located close to the stacked branch adenosine. Chembiochem : a European journal of chemical biology\| PubMed ID: 17200997	2007
Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry. Chemical reviews\| PubMed ID: 17212472	2007
Binding interaction of [Re(H2O)3(CO)3]+ with the DNA fragment d(CpGpG). Inorganic chemistry\| PubMed ID: 18001120	2007
Determination of the intrinsic affinities of multiple site-specific Mg(2+) ions coordinated to domain 6 of a group II intron ribozyme. Inorganic chemistry\| PubMed ID: 18044881	2007
Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18270983	2008
Using in vitro transcription to construct scaffolds for one-dimensional arrays of mercuric ions. Journal of inorganic biochemistry\| PubMed ID: 18289686	2008
The corrin moiety of coenzyme B12 is the determinant for switching the btuB riboswitch of E. coli. Chembiochem : a European journal of chemical biology\| PubMed ID: 18506875	2008
Divalent metal ions tune the self-splicing reaction of the yeast mitochondrial group II intron Sc.ai5gamma. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 18528718	2008
Comparison of the acid-base properties of ribose and 2'-deoxyribose nucleotides. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18567033	2008
Single-molecule studies of group II intron ribozymes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18772388	2008
Effect of the ribose versus 2'-deoxyribose residue on the metal ion-binding properties of purine nucleotides. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 18827944	2008
Divalent metal ions promote the formation of the 5'-splice site recognition complex in a self-splicing group II intron. Journal of inorganic biochemistry\| PubMed ID: 18842303	2008
Ca2+ induces the formation of two distinct subpopulations of group II intron molecules. Angewandte Chemie (International ed. in English)\| PubMed ID: 19924747	2009
Controlling ribozyme activity by metal ions. Current opinion in chemical biology\| PubMed ID: 20047851	2010
Metal ion-N7 coordination in a ribozyme branch domain by NMR. Journal of inorganic biochemistry\| PubMed ID: 20170966	2010
A stability concept for metal ion coordination to single-stranded nucleic acids and affinities of individual sites. Accounts of chemical research\| PubMed ID: 20235593	2010
The change of corrin-amides to carboxylates leads to altered structures of the B12-responding btuB riboswitch. Chemical communications (Cambridge, England)\| PubMed ID: 20830434	2011
Solution structure of a DNA double helix with consecutive metal-mediated base pairs. Nature chemistry\| PubMed ID: 21124482	2010
Shaping RNA structures with metal ions and metal ion complexes. Chimia\| PubMed ID: 21140903	2010
Stability and structure of mixed-ligand metal ion complexes that contain Ni2+, Cu2+, or Zn2+, and Histamine, as well as adenosine 5'-triphosphate (ATP4-) or uridine 5'-triphosphate (UTP(4-):... Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21465580	2011
Probing the metal-ion-binding strength of the hydroxyl group. Chemical reviews\| PubMed ID: 21595429	2011
MINAS--a database of Metal Ions in Nucleic AcidS. Nucleic acids research\| PubMed ID: 22096233	2012
Characterization of metal ion-nucleic acid interactions in solution. Metal ions in life sciences\| PubMed ID: 22210334	2012
Single molecule FRET characterization of large ribozyme folding. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22315073	2012
Metal ion-RNA interactions studied via multinuclear NMR. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22315074	2012
Unusually high-affinity Mg(2+) binding at the AU-rich sequence within the antiterminator hairpin of a Mg(2+) riboswitch. Chemistry & biodiversity\| PubMed ID: 22976989	2012
NMR spectroscopy in bioinorganic chemistry. Chimia\| PubMed ID: 23146267	2012
The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron. Nucleic acids research\| PubMed ID: 23275550	2013
Helicase-mediated changes in RNA structure at the single-molecule level. RNA biology\| PubMed ID: 23353571	2013
Complex formation of cadmium with sugar residues, nucleobases, phosphates, nucleotides, and nucleic acids. Metal ions in life sciences\| PubMed ID: 23430775	2013
Intrinsic acid-base properties of a hexa-2'-deoxynucleoside pentaphosphate, d(ApGpGpCpCpT): neighboring effects and isomeric equilibria. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23595830	2013
Distance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences. Nucleic acids research\| PubMed ID: 23771141	2013
Kinetic subpopulations detected by single-molecule spectroscopy: fundamental property of functional nucleic acids or experimental artefact? Chimia\| PubMed ID: 23967697	2013
Structure and conformational dynamics of the domain 5 RNA hairpin of a bacterial group II intron revealed by solution nuclear magnetic resonance and molecular dynamics simulations. Biochemistry\| PubMed ID: 24001362	2013
Diversity of cobalamin riboswitches in the corrinoid-producing organohalide respirer Desulfitobacterium hafniense. Journal of bacteriology\| PubMed ID: 24039263	2013
Monitoring global structural changes and specific metal-ion-binding sites in RNA by in-line probing and Tb(III) cleavage. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24136602	2014
Mg(2+)-induced conformational changes in the btuB riboswitch from E. coli. RNA (New York, N.Y.)\| PubMed ID: 24243114	2014
BOBA FRET: bootstrap-based analysis of single-molecule FRET data. PloS one\| PubMed ID: 24386343	2013
NMR structure of the 5' splice site in the group IIB intron Sc.ai5γ--conformational requirements for exon-intron recognition. RNA (New York, N.Y.)\| PubMed ID: 24448450	2014
Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts. Nature methods\| PubMed ID: 24584194	2014
Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 24652468	2014
Synthesis, physico-chemical properties and biological analysis of newly obtained copper(II) complexes with pyrazole derivatives. Journal of inorganic biochemistry\| PubMed ID: 24662465	2014
The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: solution structure and metal ion binding sites of the RNA-DNA complex. The Journal of biological chemistry\| PubMed ID: 24895129	2014
The AdoCbl-riboswitch interaction investigated by in-line probing and surface plasmon resonance spectroscopy (SPR). Methods in enzymology\| PubMed ID: 25432761	2014
Cation-induced kinetic heterogeneity of the intron-exon recognition in single group II introns. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25737541	2015
Strategy for Internal Labeling of Large RNAs with Minimal Perturbation by Using Fluorescent PNA. Chembiochem : a European journal of chemical biology\| PubMed ID: 25872497	2015
Explicit analytic equations for multimolecular thermal melting curves. Biophysical chemistry\| PubMed ID: 25910861	2015
Protonation-Dependent Base Flipping at Neutral pH in the Catalytic Triad of a Self-Splicing Bacterial Group II Intron. Angewandte Chemie (International ed. in English)\| PubMed ID: 26119804	2015
Studying metal ion binding properties of a three-way junction RNA by heteronuclear NMR. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 26880094	2016
Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme. RNA (New York, N.Y.)\| PubMed ID: 26966151	2016
The X-ray Structures of Six Octameric RNA Duplexes in the Presence of Different Di- and Trivalent Cations. International journal of molecular sciences\| PubMed ID: 27355942	2016
Sequence-Specific Post-Synthetic Oligonucleotide Labeling for Single-Molecule Fluorescence Applications. ACS chemical biology\| PubMed ID: 27409145	2016
Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 27704222	2016
An atomistic view on carbocyanine photophysics in the realm of RNA. Physical chemistry chemical physics : PCCP\| PubMed ID: 27783069	2016
Influence of pH and Mg(ii) on the catalytic core domain 5 of a bacterial group II intron. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 28265619	2017
Tb-Cleavage Assays Reveal Specific Mg Binding Sites Necessary to Pre-fold the Riboswitch for AdoCbl Binding. Frontiers in chemistry\| PubMed ID: 28377919	2017
Site-specific dual-color labeling of long RNAs for single-molecule spectroscopy. Nucleic acids research\| PubMed ID: 29136199	2018
Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 29218637	2018
Celebrating Helmut Sigel. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry\| PubMed ID: 29218638	2018
Simulations of camera-based single-molecule fluorescence experiments. PloS one\| PubMed ID: 29652886	2018
Optimal molecular crowding accelerates group II intron folding and maximizes catalysis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30397128	2018
The Bioinorganic Periodic Table. Chimia\| PubMed ID: 30890214	2019
NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance. Nucleic acids research\| PubMed ID: 30916334	2019
Stick, Flick, Click: DNA-guided Fluorescent Labeling of Long RNA for Single-molecule FRET. Chimia\| PubMed ID: 30975253	2019
Concerted dynamics of metallo-base pairs in an A/B-form helical transition. Nature communications\| PubMed ID: 31645548	2019
Site-Specific Dual-Color Labeling of Long RNAs. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31889263	2020
Metal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts. Nature communications\| PubMed ID: 31913262	2020
Encapsulation of Fluorescently Labeled RNAs into Surface-Tethered Vesicles for Single-Molecule FRET Studies in TIRF Microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32006303	2020
Screening for potential interaction partners with surface plasmon resonance imaging coupled to MALDI mass spectrometry. Analytical biochemistry\| PubMed ID: 33857502	2021
Puf6 primes 60S pre-ribosome nuclear export at low temperature. Nature communications\| PubMed ID: 34349113	2021
FRETraj: integrating single-molecule spectroscopy with molecular dynamics. Bioinformatics (Oxford, England)\| PubMed ID: 34478493	2021
Single-Molecule Kinetic Studies of Nucleic Acids by Förster Resonance Energy Transfer. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35226322	2022
Chemical Dual End-Labeling of Large Ribozymes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35226323	2022
Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations. Molecules (Basel, Switzerland)\| PubMed ID: 35565975	2022
Magnesium(II)-ATP Complexes in 1-Ethyl-3-Methylimidazolium Acetate Solutions Characterized by Mg β-Radiation-Detected NMR Spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 35718746	2022
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories. Nature communications\| PubMed ID: 36104339	2022
The structural features of the ligand-free moaA riboswitch and its ion-dependent folding. Journal of inorganic biochemistry\| PubMed ID: 36774787	2023
Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks. Journal of the American Chemical Society\| PubMed ID: 37318835	2023
Group II Introns: Highly Structured yet Dynamic. Chimia\| PubMed ID: 38047803	2023
Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages. Nature communications\| PubMed ID: 38378708	2024
From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes. Chimia\| PubMed ID: 38676609	2024
Reply to: On the statistical foundation of a recent single molecule FRET benchmark. Nature communications\| PubMed ID: 38688911	2024
FRET-guided modeling of nucleic acids. Nucleic acids research\| PubMed ID: 38869063	2024
Corrin Ring Modifications Reveal the Chemical and Spatial Requirements for the B-btuB Riboswitch Interaction. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 38922714	2024