Ralph N. Martins

Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University

Affiliated withEdith Cowan University Graylands Hospital, University of Western Australia McCusker Alzheimer's Research foundation

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 317	2012

Other Publications

Article	Year
Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment. Neurobiology of aging\| PubMed ID: 11755019	2002
Transition metal chelator therapy--a potential treatment for Alzheimer's disease? Frontiers in bioscience : a journal and virtual library\| PubMed ID: 11897554	2002
Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease. Neuroreport\| PubMed ID: 11973454	2002
Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition. Journal of neurochemistry\| PubMed ID: 12065653	2002
Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia. Annals of neurology\| PubMed ID: 12112093	2002
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides\| PubMed ID: 12128091	2002
Amyloid beta protein precursor metabolism as a modulator of islet beta-cell function. Journal of Alzheimer's disease : JAD\| PubMed ID: 12214043	2001
Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology. Journal of neuroscience research\| PubMed ID: 12391612	2002
Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of neurochemistry\| PubMed ID: 12614323	2003
Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain : a journal of neurology\| PubMed ID: 12615641	2003
Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free radical biology & medicine\| PubMed ID: 12684092	2003
Can testosterone replacement decrease the memory problem of old age? Medical hypotheses\| PubMed ID: 12699720	2003
XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. The Biochemical journal\| PubMed ID: 12780348	2003
Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological psychiatry\| PubMed ID: 12873803	2003
Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiology of aging\| PubMed ID: 12885573	2003
Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological psychiatry\| PubMed ID: 13129656	2003
Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain research. Brain research reviews\| PubMed ID: 14499458	2003
Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease. Alzheimer disease and associated disorders\| PubMed ID: 14657791	2003
Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Journal of neurochemistry\| PubMed ID: 14720205	2004
Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. The Journal of biological chemistry\| PubMed ID: 14871891	2004
One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology\| PubMed ID: 15219659	2004
Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes. Journal of neuroscience research\| PubMed ID: 15264223	2004
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. Journal of neurochemistry\| PubMed ID: 15287908	2004
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 15304237	2004
Frequency of tau mutations in familial and sporadic frontotemporal dementia and other tauopathies. Journal of neurology\| PubMed ID: 15372253	2004
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer disease and associated disorders\| PubMed ID: 15592142	2004
光纤衍射的头发可以提供在阿尔茨海默病筛查：人类&#x54... Medical science monitor : international medical journal of experimental and clinical research\| PubMed ID: 15668631	2005
Dementia and testosterone levels in men. JAMA : the journal of the American Medical Association\| PubMed ID: 15687304	2005
TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels. Human mutation\| PubMed ID: 15895461	2005
Common versus uncommon causes of dementia. International psychogeriatrics / IPA\| PubMed ID: 16240481	2005
Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's disease : JAD\| PubMed ID: 16340084	2005
Interaction between testosterone and apolipoprotein E epsilon4 status on cognition in healthy older men. The Journal of clinical endocrinology and metabolism\| PubMed ID: 16368754	2006
The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms. Endocrine\| PubMed ID: 16785601	2006
Oxidative stress in a rat model of chronic gliosis. Neurobiology of aging\| PubMed ID: 16797785	2007
A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. Human molecular genetics\| PubMed ID: 16825285	2006
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochemical research\| PubMed ID: 16944319	2007
Reproductive hormones modulate oxidative stress in Alzheimer's disease. Antioxidants & redox signaling\| PubMed ID: 17034349	2006
Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain : a journal of neurology\| PubMed ID: 17071927	2006
B-vitamins reduce plasma levels of beta amyloid. Neurobiology of aging\| PubMed ID: 17113685	2008
Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process. Experimental gerontology\| PubMed ID: 17140756	2007
Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment. Journal of Alzheimer's disease : JAD\| PubMed ID: 17183150	2006
Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions. Journal of Alzheimer's disease : JAD\| PubMed ID: 17917157	2007
Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEepsilon4 carriers in the Australian population. Journal of Alzheimer's disease : JAD\| PubMed ID: 18376055	2008
Gonadotropins and cognition in older women. Journal of Alzheimer's disease : JAD\| PubMed ID: 18430994	2008
Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism. Journal of Alzheimer's disease : JAD\| PubMed ID: 18487850	2008
Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men. Journal of Alzheimer's disease : JAD\| PubMed ID: 18560131	2008
Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of neuroinflammation\| PubMed ID: 18715507	2008
Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels. Journal of Alzheimer's disease : JAD\| PubMed ID: 18780973	2008
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of aging\| PubMed ID: 18950899	2010
Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxic... International journal of clinical and experimental medicine\| PubMed ID: 19079689	2008
Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers. Journal of Alzheimer's disease : JAD\| PubMed ID: 19363264	2009
Androgens and Alzheimer's disease. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 19373081	2009
Abeta aggregation and possible implications in Alzheimer's disease pathogenesis. Journal of cellular and molecular medicine\| PubMed ID: 19374683	2009
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease... International psychogeriatrics / IPA\| PubMed ID: 19470201	2009
The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and non-carriers. Journal of Alzheimer's disease : JAD\| PubMed ID: 19494432	2009
Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease : JAD\| PubMed ID: 19494438	2009
Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental cell research\| PubMed ID: 19563801	2009
Complex splicing and neural expression of duplicated tau genes in zebrafish embryos. Journal of Alzheimer's disease : JAD\| PubMed ID: 19584432	2009
Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: quod erat demonstrandum? International psychogeriatrics / IPA\| PubMed ID: 19814842	2010
Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular neurodegeneration\| PubMed ID: 19845940	2009
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. The Journal of biological chemistry\| PubMed ID: 19864413	2009
The structure and function of Alzheimer's gamma secretase enzyme complex. Critical reviews in clinical laboratory sciences\| PubMed ID: 19958215	2009
Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of neurochemistry\| PubMed ID: 20050287	2009
Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's disease : JAD\| PubMed ID: 20164599	2010
Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular neurodegeneration\| PubMed ID: 20205790	2010
Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Annals of neurology\| PubMed ID: 20373343	2010
Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging. Journal of Alzheimer's disease : JAD\| PubMed ID: 20413897	2010
Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 20451879	2010
APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. Journal of Alzheimer's disease : JAD\| PubMed ID: 20555142	2010
Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain : a journal of neurology\| PubMed ID: 20739349	2010
Ocular biomarkers for early detection of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 20847434	2010
Zebrafish as a tool in Alzheimer's disease research. Biochimica et biophysica acta\| PubMed ID: 20920580	2011
Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of aging\| PubMed ID: 20961668	2012
Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain : a journal of neurology\| PubMed ID: 21310725	2011
Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and geriatric cognitive disorders\| PubMed ID: 21389718	2011
A web-based normative data tool for assessing cognitive performance in healthy older Australians. The Medical journal of Australia\| PubMed ID: 21401481	2011
Advances in structural and molecular neuroimaging in Alzheimer's disease. The Medical journal of Australia\| PubMed ID: 21401483	2011
New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet neurology\| PubMed ID: 21435594	2011
Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 21460433	2011
Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study. Neuropsychologia\| PubMed ID: 21529702	2011
Alternative processing of Î³-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for Î³-secretase dysfunction. Annals of neurology\| PubMed ID: 21681798	2011
The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's disease : JAD\| PubMed ID: 21694447	2011
Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing. International psychogeriatrics / IPA\| PubMed ID: 21749739	2012
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomar... Journal of Alzheimer's disease : JAD\| PubMed ID: 21891867	2011
Direct exposure of guinea pig CNS to human luteinizing hormone increases cerebrospinal fluid and cerebral beta amyloid levels. Neuroendocrinology\| PubMed ID: 21985789	2011
Evaluation of color preference in zebrafish for learning and memory. Journal of Alzheimer's disease : JAD\| PubMed ID: 22008261	2012
Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of neuroscience methods\| PubMed ID: 22226742	2012
Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of clinical and experimental neuropsychology\| PubMed ID: 22248010	2012
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology\| PubMed ID: 22514046	2012
Multiple Î³-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular neurodegeneration\| PubMed ID: 22534039	2012
Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience letters\| PubMed ID: 22580062	2012
Regional dynamics of amyloid-Î² deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study. Brain : a journal of neurology\| PubMed ID: 22628162	2012
Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England journal of medicine\| PubMed ID: 22784036	2012
Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of neurology\| PubMed ID: 22801742	2012
Latrepirdine (Dimebonâ„¢) Enhances Autophagy and Reduces Intracellular GFP-AÎ²42 Levels in Yeast. Journal of Alzheimer's disease : JAD\| PubMed ID: 22903131	2012
Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology\| PubMed ID: 22903389	2012
Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-Î² Journal of Alzheimer's disease : JAD\| PubMed ID: 23001710	2012
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mi... BMC psychiatry\| PubMed ID: 23050829	2012
Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology\| PubMed ID: 23071163	2012
Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical investigation\| PubMed ID: 23139856	2012