Paul Cos

Laboratory for Microbiology, Parasitology and Hygiene (LMPH)

Affiliated withParasitology and Hygiene (LMPH)

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. Journal of ethnopharmacology\| PubMed ID: 16698208	2006
Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007). Planta medica\| PubMed ID: 18671200	2008
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrobial agents and chemotherapy\| PubMed ID: 19546361	2009
Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites. Parasitology international\| PubMed ID: 20696269	2010
In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species. The Journal of antimicrobial chemotherapy\| PubMed ID: 21131319	2011
An alternative, sensitive method to detect Helicobacter pylori DNA in feces. Helicobacter\| PubMed ID: 21435088	2011
Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditions. Parasitology research\| PubMed ID: 21894509	2012
Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model. Helicobacter\| PubMed ID: 22759332	2012
Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection. Parasitology\| PubMed ID: 22776404	2012
Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dye. Journal of microbiological methods\| PubMed ID: 23266389	2013
Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms. Experimental parasitology\| PubMed ID: 24184772	2014
Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates. Pathogens and disease\| PubMed ID: 24532232	2014
Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs. The Journal of antimicrobial chemotherapy\| PubMed ID: 24535279	2014
Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. ACS medicinal chemistry letters\| PubMed ID: 24900696	2013
In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis. Parasitology research\| PubMed ID: 24906989	2014
Animal models of invasive aspergillosis for drug discovery. Drug discovery today\| PubMed ID: 24931219	2014
Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 24963330	2014
Flow cytometric enumeration of bacteria using TO-PRO®-3 iodide as a single-stain viability dye. Journal of laboratory automation\| PubMed ID: 25124156	2014
In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants. Planta medica\| PubMed ID: 25180493	2014
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds. Bioorganic & medicinal chemistry\| PubMed ID: 25199582	2014
Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis. Mycoses\| PubMed ID: 25590577	2015
N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR. Bioorganic & medicinal chemistry letters\| PubMed ID: 25726328	2015
Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity. Journal of microbiological methods\| PubMed ID: 25772040	2015
The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants. Journal of ethnopharmacology\| PubMed ID: 25773488	2015
A flow cytometric approach to quantify biofilms. Folia microbiologica\| PubMed ID: 25948317	2015
Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain. PloS one\| PubMed ID: 26469696	2015
Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum. Phytotherapy research : PTR\| PubMed ID: 26514875	2015
Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model. PloS one\| PubMed ID: 26848853	2016
Evaluation of topical antifungal products in an in vitro onychomycosis model. Mycoses\| PubMed ID: 26857689	2016
Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorganic & medicinal chemistry\| PubMed ID: 26935942	2016
In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)\| PubMed ID: 26938501	2017
Optimization and validation of an existing, surgical and robust dry eye rat model for the evaluation of therapeutic compounds. Experimental eye research\| PubMed ID: 26995142	2016
The role of the globin-coupled sensor YddV in a mature E. coli biofilm population. Biochimica et biophysica acta\| PubMed ID: 27083533	2016
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Ama... PloS one\| PubMed ID: 27123924	2016
Characterizing the in vitro biofilm phenotype of Staphylococcus epidermidis isolates from central venous catheters. Journal of microbiological methods\| PubMed ID: 27196636	2016
Design, synthesis and biological evaluation of novel quinoline-based carboxylic hydrazides as anti-tubercular agents. Chemical biology & drug design\| PubMed ID: 27203404	2016
Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts. Phytotherapy research : PTR\| PubMed ID: 27282639	2016
Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents. Bioorganic & medicinal chemistry\| PubMed ID: 27614917	2016
Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate. Molecules (Basel, Switzerland)\| PubMed ID: 27681714	2016
Triterpenoid Saponins from Maesa argentea Leaves. Planta medica\| PubMed ID: 27737476	2016
Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines. Immunobiology\| PubMed ID: 27899210	2017
Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity. Journal of natural products\| PubMed ID: 27933893	2016
Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages. Cellular immunology\| PubMed ID: 27993350	2017
Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids. Molecules (Basel, Switzerland)\| PubMed ID: 28157177	2017
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models. PloS one\| PubMed ID: 28248999	2017
Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum. PLoS neglected tropical diseases\| PubMed ID: 28505185	2017
In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 28506817	2017
Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia. Journal of microbiological methods\| PubMed ID: 28587856	2017
Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28600766	2017
Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones. European journal of medicinal chemistry\| PubMed ID: 28689097	2017
Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182]. Bioorganic & medicinal chemistry\| PubMed ID: 28826595	2017
Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds. Chemical biology & drug design\| PubMed ID: 28845550	2018
Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review. Medicines (Basel, Switzerland)\| PubMed ID: 28930264	2017
Bioassay-guided Study of the Antimicrobial and Cytotoxic Properties of the Leaves from Sw. Pharmacognosy research\| PubMed ID: 29263635	2017
Microbial Community Dynamics during Rearing of Black Soldier Fly Larvae (Hermetia illucens) and Impact on Exploitation Potential. Applied and environmental microbiology\| PubMed ID: 29475866	2018
Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study. BMC pregnancy and childbirth\| PubMed ID: 29482567	2018
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. Journal of medicinal chemistry\| PubMed ID: 29510037	2018
UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes. Data in brief\| PubMed ID: 29541660	2018
Efficacy of Four spp. Extracts in an Animal Model of Cutaneous Leishmaniasis. Medicines (Basel, Switzerland)\| PubMed ID: 29874837	2018
Methodologies for and evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microbial cell (Graz, Austria)\| PubMed ID: 29992128	2018
Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization. Viruses\| PubMed ID: 30110893	2018
Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PloS one\| PubMed ID: 30204759	2018
Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain. The Journal of antimicrobial chemotherapy\| PubMed ID: 30412253	2019
HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of . Natural product research\| PubMed ID: 30602319	2020
In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark. Journal of ethnopharmacology\| PubMed ID: 30763695	2019
Antimicrobial activity of leaf extracts and isolated constituents of Croton linearis. Journal of ethnopharmacology\| PubMed ID: 30849504	2019
In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and T... Parasitology research\| PubMed ID: 30903349	2019
Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity. Virus research\| PubMed ID: 31004621	2019
Chemical Composition, Antimicrobial and Antiparasitic Screening of the Essential Oil from (Spreng.) Griseb. Molecules (Basel, Switzerland)\| PubMed ID: 31022871	2019
Opportunities for Overcoming Drug Resistance: Emerging Mycobacterial Targets and Host-Directed Therapy. International journal of molecular sciences\| PubMed ID: 31212777	2019
The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. European journal of medicinal chemistry\| PubMed ID: 31376569	2019
Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies. Antibodies (Basel, Switzerland)\| PubMed ID: 31557988	2016
1-(Piperidin-3-yl)thymine amides as inhibitors of thymidylate kinase. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 31822127	2019
Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review. Pharmaceutics\| PubMed ID: 32517052	2020
Combination of Miconazole and Domiphen Bromide Is Fungicidal against Biofilms of Resistant spp. Antimicrobial agents and chemotherapy\| PubMed ID: 32690639	2020
3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency. Materials (Basel, Switzerland)\| PubMed ID: 32751210	2020
and Evaluation of Predicted Pneumococcal UDPG:PP Inhibitors. Frontiers in microbiology\| PubMed ID: 32760374	2020
Antimicrobial investigation of ethnobotanically selected guinean plant species. Journal of ethnopharmacology\| PubMed ID: 32768641	2020
A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation. Scientific reports\| PubMed ID: 33057006	2020
Antioxidants in Plants: A Valorization Potential Emphasizing the Need for the Conservation of Plant Biodiversity in Cuba. Antioxidants (Basel, Switzerland)\| PubMed ID: 33121046	2020
Bioassay-guided isolation of antiplasmodial and antimicrobial constituents from the roots of Terminalia albida. Journal of ethnopharmacology\| PubMed ID: 33246123	2021
Essential Oil from : Antimicrobial, Antikinetoplastid, Antiproliferative and Cytotoxic Assessment. Molecules (Basel, Switzerland)\| PubMed ID: 33255562	2020
Minimum information guideline for spectrophotometric and fluorometric methods to assess biofilm formation in microplates. Biofilm\| PubMed ID: 33447797	2020
Phenols from L. and L. and their activity against carbonic anhydrase. Natural product research\| PubMed ID: 33533668	2022
Chemical and Pharmacological Potential of , an Endemic Endangered Plant from Cuba. Molecules (Basel, Switzerland)\| PubMed ID: 33578815	2021
Antiplasmodial Oleanane Triterpenoids from Root Bark. Journal of natural products\| PubMed ID: 33667089	2021
Anti-inflammatory effect of Adelia ricinella L. aerial parts. The Journal of pharmacy and pharmacology\| PubMed ID: 33793832	2021
Differential Induction Pattern Towards Classically Activated Macrophages in Response to an Immunomodulatory Extract from Mycelium. Journal of fungi (Basel, Switzerland)\| PubMed ID: 33799778	2021
Novel flavonol-3--methylethers from Griseb. (Rutaceae). Natural product research\| PubMed ID: 33813981	2022
Microbial symbionts of insects as a source of new antimicrobials: a review. Critical reviews in microbiology\| PubMed ID: 34032192	2021
Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model. Pharmaceutics\| PubMed ID: 34064276	2021
Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods. Scientific reports\| PubMed ID: 34215805	2021
Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing? International journal of pharmaceutics\| PubMed ID: 34303815	2021
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. European journal of medicinal chemistry\| PubMed ID: 34450493	2021
Antifungal Activity of Extracts, Fractions, and Constituents from Leaves. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 34577616	2021
Evaluation of Antimicrobial Peptides from the Black Soldier Fly () against a Selection of Human Pathogens. Microbiology spectrum\| PubMed ID: 34985302	2022
LC-MS Characterization and Biological Activities of Cuban Cultivars of Schltr. Plants (Basel, Switzerland)\| PubMed ID: 35009137	2022
Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds. Chemical biology & drug design\| PubMed ID: 35313075	2022
Pharmacological Screening of Essential Oils from and Growing in Brazil. Molecules (Basel, Switzerland)\| PubMed ID: 35335288	2022
Antiplasmodial activity of alkaloids from Croton linearis leaves. Experimental parasitology\| PubMed ID: 35378134	2022
A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection. Scientific reports\| PubMed ID: 35854044	2022
3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Infection in Mice. Pharmaceutics\| PubMed ID: 35890261	2022
Inhibition of Bacterial Adhesion and Biofilm Formation by Seed-Derived Ethanol Extracts from Mill. Molecules (Basel, Switzerland)\| PubMed ID: 35956958	2022
Inhibitory Effect on Nitric Oxide Release in LPS-Stimulated Macrophages and Free Radical Scavenging Activity of Jacq. Leaves. Antioxidants (Basel, Switzerland)\| PubMed ID: 36290638	2022
Antibiotic Tolerance Indicative of Persistence Is Pervasive among Clinical Streptococcus pneumoniae Isolates and Shows Strong Condition Dependence. Microbiology spectrum\| PubMed ID: 36374111	2022
Selected strategies to fight pathogenic bacteria. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 36629427	2023
Development and validation of a multiplex electrochemiluminescence immunoassay to evaluate dry eye disease in rat tear fluids. Scientific reports\| PubMed ID: 37500810	2023
Phytochemical characterization and antifungal potential of leaf extracts of . Natural product research\| PubMed ID: 37548293	2024
In-depth biological characterization of two black soldier fly anti- peptides reveals LPS-binding and immunomodulating effects. mSphere\| PubMed ID: 37800918	2023
Expanding the squaramide library as mycobacterial ATP synthase inhibitors: Innovative synthetic pathway and biological evaluation. Bioorganic & medicinal chemistry\| PubMed ID: 37871508	2023
In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models. FEMS microbiology reviews\| PubMed ID: 38409952	2024
The Liebeskind-Srogl Cross-Coupling Reaction as a Crucial Step in the Synthesis of New Squaramide-Based Antituberculosis Agents. ACS omega\| PubMed ID: 39157083	2024
Characterization of novel double-reporter strains of for drug discovery: a study in mScarlet. Microbiology spectrum\| PubMed ID: 39189762	2024
Polymyxin B Peptide Hydrogel Coating: A Novel Approach to Prevent Ventilator-Associated Pneumonia. International journal of molecular sciences\| PubMed ID: 39408597	2024