Christopher K. Glass

Department of Cellular and Molecular Medicine, University of California San Diego

Affiliated withUniversity of California San Diego

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2024

Other Publications

Article	Year
Transcriptional activation by NF-kappaB requires multiple coactivators. Molecular and cellular biology\| PubMed ID: 10454583	1999
Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation\| PubMed ID: 11901049	2002
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell\| PubMed ID: 12007404	2002
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12629224	2003
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Molecular and cellular biology\| PubMed ID: 12897148	2003
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature\| PubMed ID: 16127449	2005
Nuclear receptors versus inflammation: mechanisms of transrepression. Trends in endocrinology and metabolism: TEM\| PubMed ID: 16942889	2006
Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation\| PubMed ID: 18678783	2008
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19423650	2009
Deconstructing repression: evolving models of co-repressor action. Nature reviews. Genetics\| PubMed ID: 20084085	2010
Macrophages, inflammation, and insulin resistance. Annual review of physiology\| PubMed ID: 20148674	2010
Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nature medicine\| PubMed ID: 20154695	2010
Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. The Journal of biological chemistry\| PubMed ID: 20876532	2010
A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PloS one\| PubMed ID: 21980340	2011
PPARs and lipid ligands in inflammation and metabolism. Chemical reviews\| PubMed ID: 21988241	2011
Microglial cell origin and phenotypes in health and disease. Nature reviews. Immunology\| PubMed ID: 22025055	2011
Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS genetics\| PubMed ID: 22174696	2011
A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Molecular cell\| PubMed ID: 22424771	2012
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature\| PubMed ID: 22460952	2012
Regulation of microglia activation and deactivation by nuclear receptors. Glia\| PubMed ID: 22987512	2013
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nature immunology\| PubMed ID: 23064439	2012
Signaling by nuclear receptors. Cold Spring Harbor perspectives in biology\| PubMed ID: 23457262	2013
A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism. Bioinformatics (Oxford, England)\| PubMed ID: 23981351	2013
Vespucci: a system for building annotated databases of nascent transcripts. Nucleic acids research\| PubMed ID: 24304890	2014
Epigenomics of macrophages. Immunological reviews\| PubMed ID: 25319330	2014
The choreography of neuroinflammation in Huntington's disease. Trends in immunology\| PubMed ID: 26001312	2015
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nature immunology\| PubMed ID: 26523867	2015
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity. Immunity\| PubMed ID: 28514673	2017
Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29378911	2018
Nature and nurture of tissue-specific macrophage phenotypes. Atherosclerosis\| PubMed ID: 30343819	2019
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. Nature communications\| PubMed ID: 30679424	2019
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer. Molecular cancer therapeutics\| PubMed ID: 31018997	2019
Transcriptional and epigenetic regulation of macrophages in atherosclerosis. Nature reviews. Cardiology\| PubMed ID: 31578516	2020
Brain cell type-specific enhancer-promoter interactome maps and diseaserisk association. Science (New York, N.Y.)\| PubMed ID: 31727856	2019
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell metabolism\| PubMed ID: 31761566	2020
deficient microglia exhibit a premature aging transcriptome. Life science alliance\| PubMed ID: 31792059	2019
Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung. Nature immunology\| PubMed ID: 31959980	2020
Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Molecular cancer therapeutics\| PubMed ID: 31974273	2020
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells. The EMBO journal\| PubMed ID: 32125007	2020
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32277030	2020
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics. Circulation research\| PubMed ID: 32981416	2020
Monocyte Regulation in Homeostasis and Malignancy. Trends in immunology\| PubMed ID: 33446416	2021
Nuclei isolation of multiple brain cell types for omics interrogation. Nature protocols\| PubMed ID: 33495627	2021
Heterogeneity of HSCs in a Mouse Model of NASH. Hepatology (Baltimore, Md.)\| PubMed ID: 33550587	2021
PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33846242	2021
A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition. Scientific reports\| PubMed ID: 34282211	2021
Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease. Current opinion in hematology\| PubMed ID: 34654019	2022
Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs. eLife\| PubMed ID: 35049498	2022
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell reports\| PubMed ID: 35263587	2022
The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 35354612	2022
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity\| PubMed ID: 35931086	2022
Shared Mechanisms between Cardiovascular Disease and NAFLD. Seminars in liver disease\| PubMed ID: 36008083	2022
Human microglia phenotypes in the brain associated with HIV infection. Current opinion in neurobiology\| PubMed ID: 36194988	2022
Microglia states and nomenclature: A field at its crossroads. Neuron\| PubMed ID: 36327895	2022
CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 36333098	2022
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. eLife\| PubMed ID: 36346385	2022
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nature communications\| PubMed ID: 36646704	2023
Deep learning predicts the impact of regulatory variants on cell-type-specific enhancers in the brain. Bioinformatics advances\| PubMed ID: 36726730	2023
Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 36828281	2023
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 37155843	2023
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation. EMBO molecular medicine\| PubMed ID: 37357756	2023
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology\| PubMed ID: 37500887	2023
RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Molecular cell\| PubMed ID: 37751740	2023
A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 38165941	2024
Gene expression and chromatin conformation of microglia in virally suppressed people with HIV. Life science alliance\| PubMed ID: 39060113	2024
Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types. Advances in neurobiology\| PubMed ID: 39207711	2024
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. Nature neuroscience\| PubMed ID: 39349662	2024
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2. NPJ Parkinson's disease\| PubMed ID: 39438499	2024