Yosef Shiloh

The David and Inez Myers Laboratory for Cancer Genetics, Tel Aviv University

Affiliated withTel Aviv University tel aviv university

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9050866	1997
ATM binds to beta-adaptin in cytoplasmic vesicles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9707615	1998
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9770541	1998
Defective potassium currents in ataxia telangiectasia fibroblasts. Genes & development\| PubMed ID: 9851975	1998
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10611322	1999
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10973490	2000
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Molecular and cellular biology\| PubMed ID: 11283254	2001
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice. The EMBO journal\| PubMed ID: 11285218	2001
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes & development\| PubMed ID: 11331603	2001
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice. The Journal of biological chemistry\| PubMed ID: 11679583	2002
ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage. Oncogene\| PubMed ID: 11850813	2002
Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains. The Journal of biological chemistry\| PubMed ID: 12496286	2003
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA repair\| PubMed ID: 12509294	2002
ATM and related protein kinases: safeguarding genome integrity. Nature reviews. Cancer\| PubMed ID: 12612651	2003
ATM: ready, set, go. Cell cycle (Georgetown, Tex.)\| PubMed ID: 12695660	2003
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. Genome research\| PubMed ID: 12727897	2003
Requirement of the MRN complex for ATM activation by DNA damage. The EMBO journal\| PubMed ID: 14532133	2003
PIVOT: protein interacions visualizatiOn tool. Bioinformatics (Oxford, England)\| PubMed ID: 14960471	2004
In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia. Seminars in cancer biology\| PubMed ID: 15219622	2004
In silico identification of transcriptional regulators associated with c-Myc. Nucleic acids research\| PubMed ID: 15388797	2004
Maintaining integrity. Nature cell biology\| PubMed ID: 15459720	2004
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15788536	2005
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis. Genome biology\| PubMed ID: 15892871	2005
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Molecular cell\| PubMed ID: 15916964	2005
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. Human molecular genetics\| PubMed ID: 16150740	2005
EXPANDER--an integrative program suite for microarray data analysis. BMC bioinformatics\| PubMed ID: 16176576	2005
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation. Molecular and cellular biology\| PubMed ID: 16227609	2005
Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16294034	2005
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells. The Journal of biological chemistry\| PubMed ID: 16627474	2006
The ATM-mediated DNA-damage response: taking shape. Trends in biochemical sciences\| PubMed ID: 16774833	2006
Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage. The Journal of cell biology\| PubMed ID: 16847100	2006
Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16855104	2006
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nature cell biology\| PubMed ID: 16862143	2006
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Molecular and cellular biology\| PubMed ID: 16943424	2006
ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA repair\| PubMed ID: 17178256	2007
Programs for cell death: apoptosis is only one way to go. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17361099	2007
Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype. American journal of medical genetics. Part A\| PubMed ID: 17632790	2007
Functional genomic delineation of TLR-induced transcriptional networks. BMC genomics\| PubMed ID: 17967192	2007
MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome. Experimental neurology\| PubMed ID: 17976584	2008
SPIKE--a database, visualization and analysis tool of cellular signaling pathways. BMC bioinformatics\| PubMed ID: 18289391	2008
The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle. DNA repair\| PubMed ID: 18456574	2008
The role of the DNA damage response in neuronal development, organization and maintenance. DNA repair\| PubMed ID: 18458000	2008
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Molecular biology of the cell\| PubMed ID: 18596239	2008
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & development\| PubMed ID: 18832071	2008
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. DNA repair\| PubMed ID: 19061978	2009
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nature cell biology\| PubMed ID: 19079244	2009
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Experimental neurology\| PubMed ID: 19345213	2009
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. The EMBO journal\| PubMed ID: 19851285	2009
FBXO31: a new player in the ever-expanding DNA damage response orchestra. Science signaling\| PubMed ID: 19903939	2009
Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133864	2010
Expander: from expression microarrays to networks and functions. Nature protocols\| PubMed ID: 20134430	2010
Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20421735	2010
SPIKE: a database of highly curated human signaling pathways. Nucleic acids research\| PubMed ID: 21097778	2011
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Science signaling\| PubMed ID: 21139141	2010
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model. Journal of molecular neuroscience : MN\| PubMed ID: 21279473	2011
Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum. The Journal of biological chemistry\| PubMed ID: 21300797	2011
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Molecular cell\| PubMed ID: 21362549	2011
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO reports\| PubMed ID: 21637298	2011
A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia. The American journal of pathology\| PubMed ID: 21763675	2011
Transcriptional modulation induced by ionizing radiation: p53 remains a central player. Molecular oncology\| PubMed ID: 21795128	2011
RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response. FEBS letters\| PubMed ID: 21827756	2011
Matrin 3 binds and stabilizes mRNA. PloS one\| PubMed ID: 21858232	2011
Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain. Journal of molecular neuroscience : MN\| PubMed ID: 21922345	2012
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22134242	2011
The ATM protein: the importance of being active. The Journal of cell biology\| PubMed ID: 22869592	2012
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nature reviews. Molecular cell biology\| PubMed ID: 23486281	2013
DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population. Mechanisms of ageing and development\| PubMed ID: 23665461	2013
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nature reviews. Molecular cell biology\| PubMed ID: 23847781	2013
Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation. Science signaling\| PubMed ID: 24825921	2014
ATM: expanding roles as a chief guardian of genome stability. Experimental cell research\| PubMed ID: 25218947	2014
The COP9 signalosome is vital for timely repair of DNA double-strand breaks. Nucleic acids research\| PubMed ID: 25855810	2015
Systemic DNA damage responses in aging and diseases. Seminars in cancer biology\| PubMed ID: 26773346	2016
Genome instability: Linking ageing and brain degeneration. Mechanisms of ageing and development\| PubMed ID: 27041231	2017
Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing. Ageing research reviews\| PubMed ID: 27181190	2017
Monitoring the ATM-Mediated DNA Damage Response in the Cerebellum Using Organotypic Cultures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28477136	2017
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair. Nucleic acids research\| PubMed ID: 29253183	2018
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Molecular cell\| PubMed ID: 29499138	2018
Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype. DNA repair\| PubMed ID: 30348496	2018
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell\| PubMed ID: 30612738	2019
The EXPANDER Integrated Platform for Transcriptome Analysis. Journal of molecular biology\| PubMed ID: 31100387	2019
The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies. Cancers\| PubMed ID: 31878315	2019
The serendipitous dawn of DNA repair. Nature reviews. Molecular cell biology\| PubMed ID: 32807976	2020
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability. DNA repair\| PubMed ID: 32871349	2020
Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress. The EMBO journal\| PubMed ID: 33215756	2021
Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma. Molecular oncology\| PubMed ID: 33605536	2021
It takes three to the DNA damage response tango. Molecular & cellular oncology\| PubMed ID: 33860085	2021
The hallmarks of aging in Ataxia-Telangiectasia. Ageing research reviews\| PubMed ID: 35644374	2022
UBQLN4 promotes STING proteasomal degradation during cisplatin-induced DNA damage in triple-negative breast cancer. Clinical and translational medicine\| PubMed ID: 35839317	2022
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary. Aging\| PubMed ID: 36040386	2022
Genomic Amplification of Is a Prognostic and Treatment Resistance Factor. Cells\| PubMed ID: 36291176	2022
Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode. The Journal of investigative dermatology\| PubMed ID: 37236596	2023
Accelerated replicative senescence of ataxia-telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns. Aging cell\| PubMed ID: 37254625	2023
ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies. Blood\| PubMed ID: 38917355	2024