Patrick J. Hrdlicka

Department of Chemistry, University of Idaho

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting. The Journal of organic chemistry\| PubMed ID: 19108636	2009
C5-functionalized LNA: unparalleled hybridization properties and enzymatic stability. Chembiochem : a European journal of chemical biology\| PubMed ID: 19810078	2009
Invader LNA: efficient targeting of short double stranded DNA. Organic & biomolecular chemistry\| PubMed ID: 20401378	2010
Glowing locked nucleic acids: brightly fluorescent probes for detection of nucleic acids in cells. Journal of the American Chemical Society\| PubMed ID: 20845923	2010
Novel insights into the use of Glowing LNA as nucleic acid detection probes--influence of labeling density and nucleobases. Bioorganic & medicinal chemistry letters\| PubMed ID: 21071224	2010
C5-Functionalized DNA, LNA, and Î±-L-LNA: Positional Control of Polarity-Sensitive Fluorophores Leads to Improved SNP-Typing. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21328492	2011
Preparation of C5-functionalized locked nucleic acids (LNAs). Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]\| PubMed ID: 21400703	2011
Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology. Chemical Society reviews\| PubMed ID: 21487621	2011
High-affinity DNA targeting using readily accessible mimics of N2'-functionalized 2'-amino-α-L-LNA. The Journal of organic chemistry\| PubMed ID: 21827174	2011
Gold-peptide nanoconjugate cellular uptake is modulated by serum proteins. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22051699	2012
C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes. The Journal of organic chemistry\| PubMed ID: 22087648	2012
DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles. Chemical communications (Cambridge, England)\| PubMed ID: 22745937	2012
Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAs. Nucleic acids research\| PubMed ID: 22855561	2012
Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2'-deoxyuridines. Organic & biomolecular chemistry\| PubMed ID: 23042241	2012
DNA strands with alternating incorporations of LNA and 2'--(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes. Chemical science\| PubMed ID: 23930202	2013
Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA. The Journal of organic chemistry\| PubMed ID: 24032477	2013
Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens. Chemical communications (Cambridge, England)\| PubMed ID: 24036937	2013
Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides. Chembiochem : a European journal of chemical biology\| PubMed ID: 24038876	2013
Recognition of mixed-sequence DNA duplexes: design guidelines for invaders based on 2'-O-(pyren-1-yl)methyl-RNA monomers. The Journal of organic chemistry\| PubMed ID: 24195730	2013
Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA. The Journal of organic chemistry\| PubMed ID: 24304240	2013
C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stability. The Journal of organic chemistry\| PubMed ID: 24797769	2014
Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid). The Journal of organic chemistry\| PubMed ID: 24825249	2014
Carbohydrate-functionalized locked nucleic acids: oligonucleotides with extraordinary binding affinity, target specificity, and enzymatic stability. Organic letters\| PubMed ID: 24890872	2014
Synthesis, hybridization characteristics, and fluorescence properties of oligonucleotides modified with nucleobase-functionalized locked nucleic acid adenosine and cytidine monomers. The Journal of organic chemistry\| PubMed ID: 24933409	2014
C5-amino acid functionalized LNA: positively poised for antisense applications. Chemical communications (Cambridge, England)\| PubMed ID: 24983883	2014
Self-assembled monolayers of thiols adsorbed on Au/ZnO-functionalized silica nanosprings: photoelectron spectroscopy-analysis and detection of vaporized explosives. ACS applied materials & interfaces\| PubMed ID: 25019614	2014
Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers. Organic & biomolecular chemistry\| PubMed ID: 25144705	2014
Recognition of Double-Stranded DNA Using Energetically Activated Duplexes Modified with N2'-Pyrene-, Perylene-, or Coronene-Functionalized 2'-N-Methyl-2'-amino-DNA Monomers. The Journal of organic chemistry\| PubMed ID: 25984765	2015
Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers. Organic & biomolecular chemistry\| PubMed ID: 26055658	2015
Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes. Molecules (Basel, Switzerland)\| PubMed ID: 26230684	2015
Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications. Chemical science\| PubMed ID: 26240741	2015
Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridine. Bioorganic & medicinal chemistry letters\| PubMed ID: 26254942	2015
Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles. Chemical communications (Cambridge, England)\| PubMed ID: 26314212	2015
Increased duplex stabilization in porphyrin-LNA zipper arrays with structure dependent exciton coupling. Organic & biomolecular chemistry\| PubMed ID: 26416024	2016
Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes. Nucleic acids research\| PubMed ID: 26857548	2016
Efficient Discrimination of Single Nucleotide Polymorphisms (SNPs) Using Oligonucleotides Modified with C5-Pyrene-Functionalized DNA and Flanking Locked Nucleic Acid (LNA) Monomers. Chemistry, an Asian journal\| PubMed ID: 26994858	2016
Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes. The Journal of organic chemistry\| PubMed ID: 26998918	2016
Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers. Organic & biomolecular chemistry\| PubMed ID: 29090304	2017
25 years and still going strong: 2'-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science. Organic & biomolecular chemistry\| PubMed ID: 29135014	2017
Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties. Organic & biomolecular chemistry\| PubMed ID: 30575837	2019
Recognition of mixed-sequence DNA targets using spermine-modified Invader probes. Organic & biomolecular chemistry\| PubMed ID: 31469146	2019
Head-to-head comparison of LNA, γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA. Organic & biomolecular chemistry\| PubMed ID: 31681928	2019
Chimeric γPNA-Invader probes: using intercalator-functionalized oligonucleotides to enhance the DNA-targeting properties of γPNA. Organic & biomolecular chemistry\| PubMed ID: 31984413	2020
Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes. Organic & biomolecular chemistry\| PubMed ID: 32520054	2020
CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma. The EMBO journal\| PubMed ID: 34487363	2021
Recognition of double-stranded DNA using LNA-modified toehold Invader probes. Organic & biomolecular chemistry\| PubMed ID: 34657934	2021
Nicked Invader probes: multistranded and sequence-unrestricted recognition of double-stranded DNA. Organic & biomolecular chemistry\| PubMed ID: 34874037	2022
Serine-γPNA, Invader probes, and chimeras thereof: three probe chemistries that enable sequence-unrestricted recognition of double-stranded DNA. Organic & biomolecular chemistry\| PubMed ID: 36285843	2022
Factors Impacting Invader-Mediated Recognition of Double-Stranded DNA. Molecules (Basel, Switzerland)\| PubMed ID: 36615321	2022
Recognition of mixed-sequence double-stranded DNA regions using chimeric Invader/LNA probes. Organic & biomolecular chemistry\| PubMed ID: 39412680	2024
Conformation matters: siRNAs with antisense strands with 5'-()-vinyl-phosphonate-α-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5'-()-vinyl-phosphonate-LNA. Chemical communications (Cambridge, England)\| PubMed ID: 39431399	2024