Thomas Klonisch

Department of Human Anatomy and Cell Sciences, University of Manitoba

Affiliated withUniversity of Manitoba CancerCare Manitoba

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
INSL3 in the benign hyperplastic and neoplastic human prostate gland. International journal of oncology\| PubMed ID: 16010410	2005
The roe deer as a model for studying seasonal regulation of testis function. International journal of andrology\| PubMed ID: 16371113	2006
Dioxin exerts anti-estrogenic actions in a novel dioxin-responsive telomerase-immortalized epithelial cell line of the porcine oviduct (TERT-OPEC). Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 16431846	2006
Relaxin enhances the oncogenic potential of human thyroid carcinoma cells. The American journal of pathology\| PubMed ID: 16877360	2006
Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness. Advances in experimental medicine and biology\| PubMed ID: 18161484	2007
Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. Journal of cellular and molecular medicine\| PubMed ID: 18494941	2008
The art of killing: double stroke with apoptin and survivin as a novel approach in cancer therapy. Cancer biology & therapy\| PubMed ID: 18698166	2008
Cancer stem cell markers in common cancers - therapeutic implications. Trends in molecular medicine\| PubMed ID: 18775674	2008
The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells. Neoplasia (New York, N.Y.)\| PubMed ID: 18813355	2008
The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice. FEBS letters\| PubMed ID: 19328792	2009
HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Nucleic acids research\| PubMed ID: 19465398	2009
Fetal-maternal exchange of multipotent stem/progenitor cells: microchimerism in diagnosis and disease. Trends in molecular medicine\| PubMed ID: 19828378	2009
S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell research\| PubMed ID: 19935772	2010
INSL3 has tumor-promoting activity in thyroid cancer. International journal of cancer\| PubMed ID: 19950223	2010
Thyroid stem cells and cancer. Thyroid : official journal of the American Thyroid Association\| PubMed ID: 20001714	2009
Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochimica et biophysica acta\| PubMed ID: 20045437	2010
Three-dimensional nuclear telomere architecture is associated with differential time to progression and overall survival in glioblastoma patients. Neoplasia (New York, N.Y.)\| PubMed ID: 20126476	2010
beta-Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release. Journal of cell science\| PubMed ID: 20736308	2010
Nuclear imaging in three dimensions: a unique tool in cancer research. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft\| PubMed ID: 20800459	2010
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one\| PubMed ID: 21304979	2011
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22160308	2012
Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells. Neoplasia (New York, N.Y.)\| PubMed ID: 22745586	2012
Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts. Biochimica et biophysica acta\| PubMed ID: 23026405	2012
INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours. Oncology reports\| PubMed ID: 23128569	2013
The pentameric channel of COMPcc in complex with different fatty acids. PloS one\| PubMed ID: 23133613	2012
Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep. Molecular and cellular endocrinology\| PubMed ID: 23291342	2013
HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells. Neoplasia (New York, N.Y.)\| PubMed ID: 23479505	2013
Three-dimensional telomere dynamics in follicular thyroid cancer. Thyroid : official journal of the American Thyroid Association\| PubMed ID: 23819464	2014
C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. The Journal of pathology\| PubMed ID: 24014093	2013
Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis. Molecular immunology\| PubMed ID: 24091294	2014
Prognostic nomograms to predict oncological outcome of thyroid cancers. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24152685	2013
The changing face of thyroid cancer in a population-based cohort. Cancer medicine\| PubMed ID: 24156026	2013
Membrane potential differences and GABAA receptor expression in hepatic tumor and non-tumor stem cells. Canadian journal of physiology and pharmacology\| PubMed ID: 24383877	2014
Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells. Cell reports\| PubMed ID: 24508460	2014
Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins. Biochimica et biophysica acta\| PubMed ID: 24637330	2014
Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells. Frontiers in endocrinology\| PubMed ID: 24723911	2014
Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25361566	2015
Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 25680541	2015
Characterization of the dystrophin-glycoprotein complex in airway smooth muscle: role of δ-sarcoglycan in airway responsiveness. Canadian journal of physiology and pharmacology\| PubMed ID: 25692961	2015
RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells. Thyroid : official journal of the American Thyroid Association\| PubMed ID: 25744544	2015
Betacellulin transgenic mice develop urothelial hyperplasia and show sex-dependent reduction in urinary major urinary protein content. Experimental and molecular pathology\| PubMed ID: 25943456	2015
Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1). Cell cycle (Georgetown, Tex.)\| PubMed ID: 26030190	2015
RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer. Frontiers in endocrinology\| PubMed ID: 26322020	2015
PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival. The Journal of cell biology\| PubMed ID: 26416963	2015
Stage II differentiated thyroid cancer: A mixed bag. Journal of surgical oncology\| PubMed ID: 26628095	2016
High Mobility Group A2 protects cancer cells against telomere dysfunction. Oncotarget\| PubMed ID: 26799419	2016
Cancer stem cells, cancer-initiating cells and methods for their detection. Drug discovery today\| PubMed ID: 26976692	2016
Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA). Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 27125435	2016
Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways. The Journal of investigative dermatology\| PubMed ID: 27164299	2016
FDG-PET characteristics of Hürthle cell and follicular adenomas. Annals of nuclear medicine\| PubMed ID: 27221817	2016
Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells. British journal of pharmacology\| PubMed ID: 27443788	2017
Photodynamic N-TiO Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells. Scientific reports\| PubMed ID: 27698385	2016
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts. Oncotarget\| PubMed ID: 27705938	2016
Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada. Cancer epidemiology\| PubMed ID: 27770672	2016
A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms. Annals of medicine and surgery (2012)\| PubMed ID: 27872746	2016
Dynamics of three-dimensional telomere profiles of circulating tumor cells in patients with high-risk prostate cancer who are undergoing androgen deprivation and radiation therapies. Urologic oncology\| PubMed ID: 27956006	2017
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. Scientific reports\| PubMed ID: 28344327	2017
New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy\| PubMed ID: 28358273	2017
Corrigendum to "Epidermal Growth Factor Cytoplasmic Domain Affects ErbB Protein Degradation by the Lysosomal and Ubiquitin-Proteasome Pathway in Human Cancer Cells" [Neoplasia 14 (2012) 396-... Neoplasia (New York, N.Y.)\| PubMed ID: 28385276	2017
Dovitinib enhances temozolomide efficacy in glioblastoma cells. Molecular oncology\| PubMed ID: 28500786	2017
C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. The Journal of biological chemistry\| PubMed ID: 28726640	2017
Characterization of GPCRs in extracellular vesicle (EV). Methods in cell biology\| PubMed ID: 28964331	2017
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β in human lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 29074489	2018
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. Pharmacology & therapeutics\| PubMed ID: 29080702	2018
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites. Epigenetics & chromatin\| PubMed ID: 29126443	2017
Simple, Hackable, Size-Selective, Amine-Functionalized Fe-Oxide Nanoparticles for Biomedical Applications. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 29376382	2018
Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 29481833	2018
C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma. Molecular oncology\| PubMed ID: 29949238	2018
Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer. Translational oncology\| PubMed ID: 30119050	2018
HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells. Molecular oncology\| PubMed ID: 30289618	2019
Maternal smoking and high BMI disrupt thyroid gland development. BMC medicine\| PubMed ID: 30348172	2018
Statins: a new approach to combat temozolomide chemoresistance in glioblastoma. Journal of investigative medicine : the official publication of the American Federation for Clinical Research\| PubMed ID: 30368483	2018
A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control. Lab on a chip\| PubMed ID: 30427358	2018
Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies. Translational oncology\| PubMed ID: 30658316	2019
Emerging roles for the relaxin/RXFP1 system in cancer therapy. Molecular and cellular endocrinology\| PubMed ID: 30763603	2019
Editorial to the mini-review series on relaxin, related peptides and receptors? Molecular and cellular endocrinology\| PubMed ID: 30831203	2019
Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes. The FEBS journal\| PubMed ID: 31545550	2019
Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery. Journal of materials chemistry. B\| PubMed ID: 32263329	2013
Zika Infection Disrupts Proteins Involved in the Neurosensory System. Frontiers in cell and developmental biology\| PubMed ID: 32850779	2020
Investigations on T cell transmigration in a human skin-on-chip (SoC) model. Lab on a chip\| PubMed ID: 33616124	2021
Novel CTRP8-RXFP1-JAK3-STAT3 axis promotes Cdc42-dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells. Molecular oncology\| PubMed ID: 33960104	2022
Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes. International journal of molecular sciences\| PubMed ID: 34502484	2021
Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma. International journal of molecular sciences\| PubMed ID: 35163279	2022
Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin. Cellular and molecular neurobiology\| PubMed ID: 35896929	2023
Ubiquitin Proteasome Gene Signatures in Ependymoma Molecular Subtypes. International journal of molecular sciences\| PubMed ID: 36293188	2022
Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling. International journal of molecular sciences\| PubMed ID: 36835656	2023
Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+ mast cell subpopulation in the prostate cancer microenvironment. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 36921737	2023
C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro. International journal of molecular sciences\| PubMed ID: 37047812	2023
DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases. Biomolecules\| PubMed ID: 37892185	2023
Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment. Cancers\| PubMed ID: 38473273	2024
Characterization of HMGA2 variants expands the spectrum of Silver-Russell syndrome. JCI insight\| PubMed ID: 38516887	2024
Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis. bioRxiv : the preprint server for biology\| PubMed ID: 38529509	2024
C1QTNF Related protein 8 (CTRP8) is a marker of myeloid derived innate immune cell populations in the human breast cancer microenvironment. Biochemical pharmacology\| PubMed ID: 39542181	2024