neuronavigated-focalized-transcranial-direct-current-stimulation

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that allows the modulation of the excitability and plasticity ...

University Medicine Greifswald

Response conflicts play a prominent role in the flexible adaptation of behavior as they represent context-signals that indicate the necessity for the recruitment of cognitive control. Previous studies have highlighted the functional roles of the affectively aversive and arousing quality of the conflict signal in triggering the adaptation process. To further test this potential link with arousal, participants performed a response conflict task in two separate sessions with either transcutaneous vagus nerve stimulation (tVNS), which is assumed to activate the locus coeruleus-noradrenaline (LC-NE) system, or with neutral sham stimulation. In both sessions the N2 and P3 event-related potentials (ERP) were assessed. In line with previous findings, conflict interference, the N2 and P3 amplitude were reduced after conflict. Most importantly, this adaptation to conflict was enhanced under tVNS compared to sham stimulation for conflict interference and the N2 amplitude. No effect of tVNS on the P3 component was found. These findings suggest that tVNS increases behavioral and electrophysiological markers of adaptation to conflict. Results are discussed in the context of the potentially underlying LC-NE and other neuromodulatory (e.g., GABA) systems. The present findings add important pieces to the understanding of the neurophysiological mechanisms of conflict-triggered adjustment of cognitive control.

Transcutaneous vagus nerve stimulation (tVNS) enhances conflict-triggered adjustment of cognitive control.

Performing two similar tasks at the same time requires the shielding of the prioritized Task 1 from interference of additional Task 2 processing (between-task interference). In the present study we tested how motivational factors such as prospect of reward might drive shifts between increased proactive control, enabling task shielding, and reduced proactive control resulting in relaxed task shielding. In Experiment 1 an instruction-induced prioritization of Task 1 over Task 2 resulted in initially reduced between-task interference. With increasing time on task, however, between-task interference continuously increased, presumably because participants engaged less in proactive control resulting in reduced task shielding. In Experiment 2 the prospect of reward activated proactive control as indicated by reduced between-task interference in the Reward than in the No reward condition. In Experiment 3, we directly compared the performance of a Reward and a No reward group in a between-subject design. Whereas between-task interference again continuously increased over time in the No reward group, indicating a relaxed mode of task shielding, the Reward group displayed constant small between-task interference over time, suggesting maintained high levels of task shielding. Together these findings speak in favor of an impressive flexibility in regulating cognitive control engagement in multitasking situations. This not only shows the capacity for optimization of multitasking performance by motivational incentives but also further supports assumptions of the strategic nature of assumed processing limitations (bottlenecks) in dual-task performance.

Shielding and relaxation in multitasking: Prospect of reward counteracts relaxation of task shielding in multitasking.

The proximity of hand position alters the processing of visual stimuli. Stimuli presented close (proximal) to hands receive an enhanced allocation of visual attention compared to stimuli presented far (distal) from hands. In the present dual-task study we studied the consequences of this preferential processing when the stimulus for Task 1 (S1) and the stimulus for Task 2 (S2) were presented together and were assigned to specific response hands (R1 and R2) located proximal (at the monitor) versus distal (in the lap) to the stimuli. In two experiments, we tested whether stimulus-hand proximity affected the extent of between-task interference (i.e., influence of additional Task 2 processing on primary Task 1 processing). In Experiment 1, results showed that stimulus-hand proximity reduced the amount of between-task interference compared to the distal stimulus-hand condition. Extending these findings, in Experiment 2 a further reduction of between-task interference was obtained when a single hand was located at the monitor instead of two hands. These results are inconsistent with the assumption of a generally increased attentional processing benefit for multiple stimuli within hand space. Instead, these findings speak for a hand-specific processing benefit that supports more separate processing of two tasks. Together these findings demonstrate that stimulus-hand proximity affects the quality of multiple task performance, which is discussed in the context of both, basic and applied cognitive research.

Embodied cognition in multitasking: increased hand-specific task shielding when stimuli are presented near the hand.

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation(VNS) and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice.

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).

Task shielding is an important executive control demand in dual-task performance enabling the segregation of stimulus-response translation processes in each task to minimize between-task interference. Although neuroimaging studies have shown activity in left dorsolateral prefrontal cortex (dlPFC) during various multitasking performances, the specific role of dlPFC in task shielding, and whether non-invasive brain stimulation (NIBS) may facilitate task shielding remains unclear. We therefore applied a single-blind, crossover sham-controlled design in which 34 participants performed a dual-task experiment with either anodal transcranial direct current stimulation (atDCS, 1 mA, 20 min) or sham tDCS (1 mA, 30 s) over left dlPFC. Task shielding was assessed by the backward-crosstalk effect, indicating the extent of between-task interference in dual tasks. Between-task interference was largest at high temporal overlap between tasks, i.e., at short stimulus onset asynchrony (SOA). Most importantly, in these conditions of highest multitasking demands, atDCS compared to sham stimulation significantly reduced between-task interference in error rates. These findings extend previous neuroimaging evidence and support modulation of successful task shielding through a conventional tDCS setup with anodal electrode over the left dlPFC. Moreover, our results demonstrate that NIBS can improve shielding of the prioritized task processing, especially in conditions of highest vulnerability to between-task interference.

Modulation of the executive control network by anodal tDCS over the left dorsolateral prefrontal cortex improves task shielding in dual tasking.

Facial expressions play a crucial role in human interactions. Typically, a positive (negative) expression evokes a congruent positive (negative) reaction within the observer. This congruent behavior is inverted, however, when the same positive (negative) expression is displayed by an outgroup member. Two approaches provide an explanation for this phenomenon. The social intentions account proposes underlying social messages within the facial display, whereas the processing conflict account assumes an affective conflict triggered by incongruent combinations of emotion and the affective connotation of group membership. In three experiments, we aimed at further substantiating the processing conflict account by separating the affective conflict from potential social intentions. For this, we created a new paradigm, in which the participant was an outside observer of a social interaction scene between two faces. Participants were required to respond to the emotional target person that could represent an ingroup or outgroup member. In all three experiments, irrespective of any social intention, responses were consistently affected by the group relation between participant and emotional target, i.e., the affective (in)congruency of the target seen by participants. These results further support the processing conflict account. The implications for the two theoretical accounts are discussed.

When a smile is still a conflict: Affective conflicts from emotional facial expressions of ingroup or outgroup members occur irrespective of the social interaction context.

Transcranial direct current stimulation (tDCS) has been studied extensively for its potential to enhance human cognitive functions in healthy individuals and to treat cognitive impairment in various clinical populations. However, little is known about how tDCS modulates the neural networks supporting cognition and the complex interplay with mediating factors that may explain the frequently observed variability of stimulation effects within and between studies. Moreover, research in this field has been characterized by substantial methodological variability, frequent lack of rigorous experimental control and small sample sizes, thereby limiting the generalizability of findings and translational potential of tDCS. The present manuscript aims to delineate how these important issues can be addressed within a neuroimaging context, to reveal the neural underpinnings, predictors and mediators of tDCS-induced behavioral modulation. We will focus on functional magnetic resonance imaging (fMRI), because it allows the investigation of tDCS effects with excellent spatial precision and sufficient temporal resolution across the entire brain. Moreover, high resolution structural imaging data can be acquired for precise localization of stimulation effects, verification of electrode positions on the scalp and realistic current modeling based on individual head and brain anatomy. However, the general principles outlined in this review will also be applicable to other imaging modalities. Following an introduction to the overall state-of-the-art in this field, we will discuss in more detail the underlying causes of variability in previous tDCS studies. Moreover, we will elaborate on design considerations for tDCS-fMRI studies, optimization of tDCS and imaging protocols and how to assure high-level experimental control. Two additional sections address the pressing need for more systematic investigation of tDCS effects across the healthy human lifespan and implications for tDCS studies in age-associated disease, and potential benefits of establishing large-scale, multidisciplinary consortia for more coordinated tDCS research in the future. We hope that this review will contribute to more coordinated, methodologically sound, transparent and reproducible research in this field. Ultimately, our aim is to facilitate a better understanding of the underlying mechanisms by which tDCS modulates human cognitive functions and more effective and individually tailored translational and clinical applications of this technique in the future.

Article	Year
Transcutaneous vagus nerve stimulation (tVNS) enhances conflict-triggered adjustment of cognitive control. Cognitive, affective & behavioral neuroscience\| PubMed ID: 29693214	2018
Shielding and relaxation in multitasking: Prospect of reward counteracts relaxation of task shielding in multitasking. Acta psychologica\| PubMed ID: 30245307	2018
Embodied cognition in multitasking: increased hand-specific task shielding when stimuli are presented near the hand. Psychological research\| PubMed ID: 30980238	2020
International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020). Frontiers in human neuroscience\| PubMed ID: 33854421	2020
Modulation of the executive control network by anodal tDCS over the left dorsolateral prefrontal cortex improves task shielding in dual tasking. Scientific reports\| PubMed ID: 37061588	2023
When a smile is still a conflict: Affective conflicts from emotional facial expressions of ingroup or outgroup members occur irrespective of the social interaction context. Acta psychologica\| PubMed ID: 37603901	2023
Investigating the neural mechanisms of transcranial direct current stimulation effects on human cognition: current issues and potential solutions. Frontiers in neuroscience\| PubMed ID: 38957187	2024

Rico Fischer

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