Simon A. Gayther

Department of Preventive Medicine, University of Southern California

Affiliated withUniversity of Southern California

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2012

Other Publications

Article	Year
Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer. Human mutation\| PubMed ID: 17688236	2007
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer research\| PubMed ID: 17409409	2007
BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. Breast cancer research : BCR\| PubMed ID: 11879560	2002
Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. American journal of human genetics\| PubMed ID: 12474142	2003
BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases. Cancer research\| PubMed ID: 12543797	2003
Histopathology, FIGO stage, and BRCA mutation status of ovarian cancers from the Gilda Radner Familial Ovarian Cancer Registry. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 14668547	2004
A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15077121	2004
STK15 polymorphisms and association with risk of invasive ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 15466974	2004
A molecular genetic and statistical approach for the diagnosis of dual-site cancers. Journal of the National Cancer Institute\| PubMed ID: 15467033	2004
Common variants in mismatch repair genes and risk of invasive ovarian cancer. Carcinogenesis\| PubMed ID: 16774946	2006
Ovarian cancer aetiology: facts and fiction. The journal of family planning and reproductive health care / Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists\| PubMed ID: 16824296	2006
Common variants in RB1 gene and risk of invasive ovarian cancer. Cancer research\| PubMed ID: 17047088	2006
Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer. PloS one\| PubMed ID: 17342202	2007
Screening for the BRCA1-ins6kbEx13 mutation: potential for misdiagnosis. Mutation in brief #964. Online. Human mutation\| PubMed ID: 17397054	2007
Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation... Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 18086758	2007
Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18281541	2008
A Perl toolkit for LIMS development. Source code for biology and medicine\| PubMed ID: 18353174	2008
A suite of Perl modules for handling microarray data. Bioinformatics (Oxford, England)\| PubMed ID: 18353790	2008
Consortium analysis of 7 candidate SNPs for ovarian cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 18431743	2008
BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18559594	2008
Multiple loci with different cancer specificities within the 8q24 gene desert. Journal of the National Cancer Institute\| PubMed ID: 18577746	2008
Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 18723338	2008
The effects of common genetic variants in oncogenes on ovarian cancer survival. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18794094	2008
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18794095	2008
Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer. Cancer research\| PubMed ID: 18974127	2008
Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells. International journal of cancer. Journal international du cancer\| PubMed ID: 19058220	2009
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 19064572	2008
The clonal evolution of metastases from primary serous epithelial ovarian cancers. International journal of cancer. Journal international du cancer\| PubMed ID: 19123469	2009
Ovarian cancer: a clinical challenge that needs some basic answers. PLoS medicine\| PubMed ID: 19192945	2009
Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 19258477	2009
Risk of ovarian cancer in women with first-degree relatives with cancer. Acta obstetricia et gynecologica Scandinavica\| PubMed ID: 19266357	2009
Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Human molecular genetics\| PubMed ID: 19270026	2009
Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. Cancer research\| PubMed ID: 19276375	2009
Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Human molecular genetics\| PubMed ID: 19304784	2009
The contribution of BRCA1 and BRCA2 to ovarian cancer. Molecular oncology\| PubMed ID: 19383375	2009
Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer. PloS one\| PubMed ID: 19543528	2009
Eligibility for magnetic resonance imaging screening in the United Kingdom: effect of strict selection criteria and anonymous DNA testing on breast cancer incidence in the MARIBS Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 19567506	2009
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nature genetics\| PubMed ID: 19648919	2009
Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study. Breast cancer research : BCR\| PubMed ID: 19903338	2009
An epigenetic signature in peripheral blood predicts active ovarian cancer. PloS one\| PubMed ID: 20019873	2009
ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 20056644	2010
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 20142253	2010
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome research\| PubMed ID: 20219944	2010
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 20360942	2010
The inherited genetics of ovarian and endometrial cancer. Current opinion in genetics & development\| PubMed ID: 20456938	2010
Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium. International journal of cancer. Journal international du cancer\| PubMed ID: 20473893	2011
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 20570913	2010
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS genetics\| PubMed ID: 20628624	2010
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 20635389	2011
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia (New York, N.Y.)\| PubMed ID: 20651987	2010
Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort. Fertility and sterility\| PubMed ID: 20719308	2011
Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival. Gynecologic oncology\| PubMed ID: 20832104	2010
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nature genetics\| PubMed ID: 20852631	2010
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nature genetics\| PubMed ID: 20852632	2010
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nature genetics\| PubMed ID: 20852633	2010
Recruitment of newly diagnosed ovarian cancer patients proved challenging in a multicentre biobanking study. Journal of clinical epidemiology\| PubMed ID: 21074968	2011
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute\| PubMed ID: 21169536	2011
Profiling signatures of ovarian cancer tumour suppression using 2D-DIGE and 2D-LC-MS/MS with tandem mass tagging. Journal of proteomics\| PubMed ID: 21237297	2011
Cancer stem cells and epithelial ovarian cancer. Journal of oncology\| PubMed ID: 21318146	2010
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21385923	2011
Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 21415361	2011
Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. Human molecular genetics\| PubMed ID: 21422097	2011
A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival. BMC cancer\| PubMed ID: 21457553	2011
LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer research\| PubMed ID: 21482675	2011
A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies. International journal of molecular epidemiology and genetics\| PubMed ID: 21532840	2010
Principles for the post-GWAS functional characterization of cancer risk loci. Nature genetics\| PubMed ID: 21614091	2011
MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 21636674	2011
Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium. PloS one\| PubMed ID: 21637745	2011
Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. PloS one\| PubMed ID: 21673961	2011
Modelling genetic and clinical heterogeneity in epithelial ovarian cancers. Carcinogenesis\| PubMed ID: 21859834	2011
Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Human molecular genetics\| PubMed ID: 21890493	2011
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PloS one\| PubMed ID: 21949822	2011
Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 22144499	2012
Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Human mutation\| PubMed ID: 22253144	2012
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA : the journal of the American Medical Association\| PubMed ID: 22274685	2012
Ovarian cancer risk associated with inherited inflammation-related variants. Cancer research\| PubMed ID: 22282663	2012
Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 22302016	2012
Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the ovarian cancer association consortium (OCAC). Journal of internal medicine\| PubMed ID: 22309431	2012
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast cancer research : BCR\| PubMed ID: 22348646	2012
Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 22351618	2012
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. The lancet oncology\| PubMed ID: 22361336	2012
Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 22454379	2012
Inherited risk of ovarian cancer and the implications for screening. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society\| PubMed ID: 22543911	2012
Genome-Wide Association Study for Ovarian Cancer Susceptibility Using Pooled DNA. Twin research and human genetics : the official journal of the International Society for Twin Studies\| PubMed ID: 22794196	2012