Fu-Shin Yu

Departments of Ophthalmology and Anatomy and Cell Biology, Wayne State University School of Medicine

Affiliated withWayne State University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes and infection\| PubMed ID: 16242370	2006
Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology\| PubMed ID: 16423036	2006
Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells. Immunology\| PubMed ID: 16423052	2006
Toll-like receptors and the eye. Investigative ophthalmology & visual science\| PubMed ID: 16565355	2006
Toll-like receptors and corneal innate immunity. Current molecular medicine\| PubMed ID: 16712478	2006
SRC-family tyrosine kinases in wound- and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 16799022	2006
Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor. Investigative ophthalmology & visual science\| PubMed ID: 17251460	2007
Staphylococcus aureus protein A induced inflammatory response in human corneal epithelial cells. Biochemical and biophysical research communications\| PubMed ID: 17270147	2007
Wound-induced ATP release and EGF receptor activation in epithelial cells. Journal of cell science\| PubMed ID: 17284517	2007
Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing. Investigative ophthalmology & visual science\| PubMed ID: 17460286	2007
Modulation of corneal epithelial innate immune response to pseudomonas infection by flagellin pretreatment. Investigative ophthalmology & visual science\| PubMed ID: 17898290	2007
Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis. Infection and immunity\| PubMed ID: 17938214	2008
Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2. Microbial pathogenesis\| PubMed ID: 18191935	2008
Role of small GTPase Rho in regulating corneal epithelial wound healing. Investigative ophthalmology & visual science\| PubMed ID: 18326710	2008
Rho kinases regulate corneal epithelial wound healing. American journal of physiology. Cell physiology\| PubMed ID: 18495812	2008
ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. Investigative ophthalmology & visual science\| PubMed ID: 18658095	2009
Lack of MD-2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness. Immunology and cell biology\| PubMed ID: 18936773	2009
High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing. Diabetes\| PubMed ID: 19188434	2009
Growth factors and corneal epithelial wound healing. Brain research bulletin\| PubMed ID: 19733636	2010
LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas. Investigative ophthalmology & visual science\| PubMed ID: 19797203	2010
Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene. Investigative ophthalmology & visual science\| PubMed ID: 19933191	2010
Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. The Journal of infectious diseases\| PubMed ID: 19995266	2010
Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway. PloS one\| PubMed ID: 20195469	2010
UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy. PloS one\| PubMed ID: 20505825	2010
Topical flagellin protects the injured corneas from Pseudomonas aeruginosa infection. Microbes and infection / Institut Pasteur\| PubMed ID: 20601077	2010
Topical flagellin-mediated innate defense against Candida albicans keratitis. Investigative ophthalmology & visual science\| PubMed ID: 21310913	2011
Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats. Investigative ophthalmology & visual science\| PubMed ID: 21330660	2011
Corneal complications in streptozocin-induced type I diabetic rats. Investigative ophthalmology & visual science\| PubMed ID: 21715347	2011
Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair. The American journal of pathology\| PubMed ID: 21924232	2011
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. PloS one\| PubMed ID: 22363806	2012
Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. Journal of dermatological science\| PubMed ID: 22999682	2012
Reduced innervation and delayed re-innervation after epithelial wounding in type 2 diabetic Goto-Kakizaki rats. The American journal of pathology\| PubMed ID: 23063510	2012
Interferon regulatory factor-1 in flagellin-induced reprogramming: potential protective role of CXCL10 in cornea innate defense against Pseudomonas aeruginosa infection. Investigative ophthalmology & visual science\| PubMed ID: 24130180	2013
Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of ep... Diabetes\| PubMed ID: 24306208	2014
Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases. The Indian journal of medical research\| PubMed ID: 24434316	2013
Pathogenicity of ocular isolates of Acinetobacter baumannii in a mouse model of bacterial endophthalmitis. Investigative ophthalmology & visual science\| PubMed ID: 24644055	2014
Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection. European journal of immunology\| PubMed ID: 24965580	2014
Matrix Metalloproteinase-13 as a Target for Suppressing Corneal Ulceration Caused by Pseudomonas aeruginosa Infection. The Journal of infectious diseases\| PubMed ID: 25589337	2015
Hyperglycemia-suppressed expression of Serpine1 contributes to delayed epithelial wound healing in diabetic mouse corneas. Investigative ophthalmology & visual science\| PubMed ID: 26024123	2015
Chitinase 3-Like 1 Promotes Candida albicans Killing and Preserves Corneal Structure and Function by Controlling Host Antifungal Responses. Infection and immunity\| PubMed ID: 26238714	2015
New insights into microRNAs in skin wound healing. IUBMB life\| PubMed ID: 26596866	2015
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance. Allergy\| PubMed ID: 26948524	2016
Dendritic cell dysfunction and diabetic sensory neuropathy in the cornea. The Journal of clinical investigation\| PubMed ID: 27064280	2016
Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas. The American journal of pathology\| PubMed ID: 27109611	2016
TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis. Oncotarget\| PubMed ID: 27224924	2016
Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin. The Journal of biological chemistry\| PubMed ID: 27637329	2016
Intraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea. Scientific reports\| PubMed ID: 27805041	2016
Zika virus infects cells lining the blood-retinal barrier and causes chorioretinal atrophy in mouse eyes. JCI insight\| PubMed ID: 28239662	2017
IL-24 Promotes Keratitis in C57BL/6 Mouse Corneas. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28330899	2017
Sensory nerve regeneration after epithelium wounding in normal and diabetic cornea. Expert review of ophthalmology\| PubMed ID: 28446923	2015
ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis. Investigative ophthalmology & visual science\| PubMed ID: 28599020	2017
CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13. Angiogenesis\| PubMed ID: 28623423	2017
Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. Diabetes\| PubMed ID: 29615440	2018
Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Infection in C57BL/6 Mouse Corneas. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29891552	2018
TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Investigative ophthalmology & visual science\| PubMed ID: 30128494	2018
Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. Diabetes\| PubMed ID: 30679185	2019
IL-17 Promotes Keratitis in C57BL/6 Mouse Corneas. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 31767781	2020
Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas. Diabetes\| PubMed ID: 32345752	2020
ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas. Investigative ophthalmology & visual science\| PubMed ID: 32416603	2020
Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis. Investigative ophthalmology & visual science\| PubMed ID: 33970198	2021
IL-36α Enhances Host Defense against Keratitis in C57BL/6 Mouse Corneas. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34686582	2021
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas. Progress in retinal and eye research\| PubMed ID: 34991965	2022
Ocular nociception and neuropathic pain initiated by blue light stress in C57BL/6J mice. Pain\| PubMed ID: 37093736	2023
Protective effects of resolvin D1 in Pseudomonas aeruginosa keratitis. Molecular immunology\| PubMed ID: 37104999	2023
Diabetes Exacerbates Pseudomonas aeruginosa Keratitis in Streptozotocin-Induced and db/db Mice via Altering Programmed Cell Death Pathways. Investigative ophthalmology & visual science\| PubMed ID: 37279395	2023
Reply to Moulton et al. Pain\| PubMed ID: 37326462	2023
Lack of Elevated Expression of TGFβ3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas. Investigative ophthalmology & visual science\| PubMed ID: 38546583	2024
Combination Nanomedicine Strategy for Preventing High-Risk Corneal Transplantation Rejection. ACS nano\| PubMed ID: 39074146	2024