C. David Weaver

Department of Pharmacology, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2013

Other Publications

Article	Year
A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. Journal of biomolecular screening\| PubMed ID: 15634793	2004
A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Molecular pharmaceutics\| PubMed ID: 15832502	2004
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Molecular pharmacology\| PubMed ID: 18171729	2008
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular pharmacology\| PubMed ID: 18664603	2008
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorganic & medicinal chemistry letters\| PubMed ID: 18774291	2008
Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers. Bioorganic & medicinal chemistry letters\| PubMed ID: 18824351	2008
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular pharmacology\| PubMed ID: 19047481	2009
Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19279215	2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. Journal of medicinal chemistry\| PubMed ID: 19438238	2009
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorganic & medicinal chemistry letters\| PubMed ID: 19443219	2009
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). Journal of medicinal chemistry\| PubMed ID: 19469556	2009
High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Molecular pharmacology\| PubMed ID: 19706730	2009
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe. Current topics in medicinal chemistry\| PubMed ID: 19807667	2009
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorganic & medicinal chemistry letters\| PubMed ID: 19854049	2009
Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorganic & medicinal chemistry letters\| PubMed ID: 19875287	2009
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Molecular pharmacology\| PubMed ID: 20026717	2010
Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening. ACS chemical neuroscience\| PubMed ID: 20414370	2010
Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & medicinal chemistry letters\| PubMed ID: 20667732	2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic an... Molecular pharmacology\| PubMed ID: 20923853	2010
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Molecular pharmacology\| PubMed ID: 20926757	2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorganic & medicinal chemistry letters\| PubMed ID: 21194936	2011
Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS chemical biology\| PubMed ID: 21241068	2011
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4... Journal of medicinal chemistry\| PubMed ID: 21247167	2011
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay. European journal of pharmacology\| PubMed ID: 21296065	2011
Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold. Bioorganic & medicinal chemistry letters\| PubMed ID: 21315585	2011
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluâ‚„. ACS combinatorial science\| PubMed ID: 21338051	2011
High-throughput quantification of bioactive lipids by MALDI mass spectrometry: application to prostaglandins. Analytical chemistry\| PubMed ID: 21770391	2011
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. The Journal of biological chemistry\| PubMed ID: 21795696	2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS chemical neuroscience\| PubMed ID: 21961051	2010
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positiv... Journal of medicinal chemistry\| PubMed ID: 21966889	2011
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Molecular pharmacology\| PubMed ID: 22021324	2012
MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines. Tetrahedron letters\| PubMed ID: 22090663	2009
Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. Frontiers in pharmacology\| PubMed ID: 22275899	2011
The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS chemical neuroscience\| PubMed ID: 22368764	2011
Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators. Journal of molecular modeling\| PubMed ID: 22592386	2012
A biased ligand for OXE-R uncouples GÎ± and GÎ²Î³ signaling within a heterotrimer. Nature chemical biology\| PubMed ID: 22634634	2012
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorganic & medicinal chemistry letters\| PubMed ID: 22727639	2012
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorganic & medicinal chemistry letters\| PubMed ID: 22981332	2012
Identification and characterization of a compound that protects cardiac tissue from human Ether-Ã -go-go-related gene (hERG)-related drug-induced arrhythmias. The Journal of biological chemistry\| PubMed ID: 23033485	2012
Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. ACS chemical neuroscience\| PubMed ID: 23077721	2012
Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database. Molecules (Basel, Switzerland)\| PubMed ID: 23299552	2013
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS medicinal chemistry letters\| PubMed ID: 23308336	2010