establishing-swine-model-to-study-uterus-dynamic-preservation

Establishing a Swine Model to Study Uterus Dynamic Preservation and Transplantation

To date, uterus transplantation is the only option for women with absolute uterine infertility, such as those with Rokitansky syndrome, to experience ...

CHU de Rennes, University of Rennes

[First step to human uterus transplantation: Setting-up of an animal model with video].

The aim of this review is to summarize the development of UT on worldwide and to develop the new questions posed by this technique in 2020.

[Uterus transplantation, current prospect and future indications. State of art with review of literature].

Uterine transplant (UT) represents an opportunity to treat absolute uterine infertility. However, the use of uterine veins for venous return, in addition to ovarian veins, significantly increases the risk of ureteral wounds in the living donor and UT time for the recipient. Our aim was to demonstrate that dual ovarian venous return is sufficient for graft viability and survival.

Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig.

To provide guidelines from the French College of Obstetricians and Gynaecologists (CNGOF), based on the best evidence available, concerning the impact of endometrial destruction on bleeding and endometrial cancer risk reduction in patients candidates for operative hysteroscopy.

In which cases should endometrial destruction be performed during an operative hysteroscopy? Clinical practice guidelines from the French College of Gynaecologists and Obstetricians (CNGOF).

Hemostasis Hysterectomy (HH) is a last resort surgical procedure performed in situations of uncontrolled post-partum hemorrhage in maternity wards. The chances of being confronted with this situation are scarce during residency, and the situation is not well suited for teaching. Nevertheless, every obstetrician-gynecologist can be confronted with this stressful situation, and should therefore possess the surgical competence required, regardless of his routine practice. The aim of the present study is to evaluate clinical exposure and self-awareness concerning HH amongst obstetrics and gynecology residents and fellows.

Assessment of the self-confidence of obstetrics & gynecology fellows to perform a postpartum hemostasis hysterectomy.

To describe the feasibility of hypothermic machine perfusion (HMP) in uterus transplantation (UT) to potentially improve the preservation of the uterus and enhance graft preservation in the donation after brainstem death (DBD) context. Uterus transplantation is a new surgical approach to treating absolute uterine infertility; it can be performed after living donation or after DBD. In the DBD context, the uterus is typically the last organ removed after other vital organs, with the exception of the Baylor team, which removes the uterus first. This key aspect imposes an unavoidable mild temperature ischemia for >1 hour on the uterus during the removal of the vital abdominal and chest organs. In renal transplantation, the perfusion machine reduces the risk of delayed graft function; thus, we hypothesized that machine perfusion could result in a reduction of uterus graft dysfunction. The uterus graft dysfunction could be expressed by a low embryo implantation rate, pregnancy loss, or vascular pregnancy diseases such as preeclampsia or fetal growth restriction." To date, static cold storage of the uterus is the only standard method for preservation before transplantation. HMP is an emerging method that could potentially improve the preservation of the uterus to enhance graft preservation in the DBD context.

Hypothermic machine perfusion for uterus transplantation.

Metroplasty is a procedure used by some teams to correct certain uterine anomalies to improve fertility outcomes. Our goal was to evaluate hysteroscopic metroplasty in the management of nulliparous and infertile patients with a uterine anomalies.

Article	Year
[First step to human uterus transplantation: Setting-up of an animal model with video]. Gynecologie, obstetrique, fertilite & senologie\| PubMed ID: 31398446	2019
[Uterus transplantation, current prospect and future indications. State of art with review of literature]. Gynecologie, obstetrique, fertilite & senologie\| PubMed ID: 32916317	2021
Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig. Journal of gynecology obstetrics and human reproduction\| PubMed ID: 33421624	2021
In which cases should endometrial destruction be performed during an operative hysteroscopy? Clinical practice guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). Journal of gynecology obstetrics and human reproduction\| PubMed ID: 34166864	2021
Assessment of the self-confidence of obstetrics & gynecology fellows to perform a postpartum hemostasis hysterectomy. Journal of gynecology obstetrics and human reproduction\| PubMed ID: 36781074	2023
Hypothermic machine perfusion for uterus transplantation. Fertility and sterility\| PubMed ID: 37660880	2023
Hysteroscopic metroplasty: Ultrasound parameters to optimize fertility benefits? Journal of gynecology obstetrics and human reproduction\| PubMed ID: 39159859	2024

Ludivine Dion

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