acupoint-catgut-embedding-therapy-traditional-chinese-medicine-for

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupuncture Point Embedding Therapy is a comprehensive treatment method that combines modern biomaterials with acupuncture techniques. Acupoint catgut ...

preliminary-study-on-acupuncture-combined-with-grain-sized

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Most patients with rheumatoid arthritis (RA) often start with pain and swelling in the joints of the extremities, especially the small joints of the ...

hospital of chengdu university of traditional chinese medicine

Chengdu University of Traditional Chinese Medicine

The rapid deterioration and progression of hepatocellular carcinoma (HCC) is intimately associated with copper ion overload, and integrating the cuproptosis mechanism for the treatment of HCC presents a promising prospect. Nevertheless, cell death complexity renders efficient removal of all HCC cells insufficient solely relying on the cuproptosis pathway. Herein, the GSH-responsive prodrug hybridization nanoassembly CA-4S@ES-Cu is exploited, which targets the delivery of copper ions to mitochondria via Elesclomol, contributing to mitochondrial dysfunction and evoking cuproptosis. Simultaneously, CA-4S depletes GSH to release CA-4, disrupting microtubule function and suppressing HCC cell proliferation and angiogenesis, to realize a dual attack against copper ion-mediated deterioration and metastasis of HCC. Furthermore, both in the HCC mouse model synergistically elicit oxidative stress to amplify the cuproptosis effect and release activated immunogenetic cell death to initiate a vigorous antitumor immune response in cascade assault modality. Conclusively, the multilevel synergistic assault penetrates the limitations of single therapy and implements a multidimensional targeted treatment for HCC.

Responsive ROS-Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults.

Citrus reticulata Blanco, a traditional Chinese herb, has been utilized for bronchitis-related conditions. Nobiletin (NOB), the primary bioactive compound in Citrus reticulata Blanco, exhibits anti-inflammatory, antioxidant, and antifibrotic properties. However, the efficacy of NOB in pulmonary fibrosis (PF) and the underlying mechanisms remain ambiguous.

ArticleTotal : 2	Year
Publication title Cited by 2	2024
Publication title	2025

Article	Year
Responsive ROS-Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40323152	2025
Nobiletin from Citrus reticulata Blanco Alleviates Pulmonary Fibrosis through Inhibiting the PI3K/AKT pathway and Epithelial-mesenchymal Transition. Journal of ethnopharmacology\| PubMed ID: 40354836	2025

Fengjiao Zhou

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