induction-of-retinal-ischemia-reperfusion-injury-in-a-mouse-eye-model

Induction of Retinal Ischemia-Reperfusion Injury in a Mouse Eye Model

Ischemia-reperfusion injuries are known to cause a range of retinal pathologies, including diabetic retinopathy, glaucoma, retinal vascular occlusions, ...

Boston University Chobanian & Avedisian School of Medicine

Evaluate racial and ethnic representation in clinical trials compared to the disease burden for diabetic retinopathy (DR) and diabetic macular edema (DME) within the United States (US). Diabetic retinopathy (DR) is currently the leading cause of blindness in American adults, affecting over 7.7 million individuals and disproportionately affecting Black Americans. Black patients represent 38.3 ± 16.5% of DME within the US population while White patients represented 44.6 ± 18.3% of the DME population in the US.

Race and ethnic representation among clinical trials for diabetic retinopathy and diabetic macular edema within the United States: A review.

Several ophthalmic diseases disproportionately affect racial and ethnic minority patients, yet most clinical trials struggle to enroll cohorts that are demographically representative of disease burden; some barriers to recruitment include time and transportation, language and cultural differences, and fear and mistrust of research due to historical abuses. Incorporating diversity within the research team has been proposed as a method to increase trust and improve engagement among potential study participants.

Diverse Research Teams and Underrepresented Groups in Clinical Studies.

To present an uncommon cause of intermittent angle closure in a young adult patient presenting with intermittent headache and blurry vision exacerbated by accommodation.

Article	Year
Race and ethnic representation among clinical trials for diabetic retinopathy and diabetic macular edema within the United States: A review. Journal of the National Medical Association\| PubMed ID: 35078668	2022
Diverse Research Teams and Underrepresented Groups in Clinical Studies. JAMA ophthalmology\| PubMed ID: 37856135	2023
A case of accommodation-induced lens subluxation with iris displacement causing intermittent angle closure. American journal of ophthalmology case reports\| PubMed ID: 38389701	2024

Nayan Sanjiv

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