Wenwen Yu

Department of Immunology and Biotherapy, Tianjin Medical University Cancer Institute and Hospital

Affiliated withTianjin Medical University Cancer Institute and Hospital

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells. Journal of experimental & clinical cancer research : CR\| PubMed ID: 21917155	2011
Enhanced activation of human dendritic cells by silencing SOCS1 and activating TLRs simultaneously. Cancer immunology, immunotherapy : CII\| PubMed ID: 22366886	2012
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23440412	2013
Can the dual-functional capability of CIK cells be used to improve antitumor effects? Cellular immunology\| PubMed ID: 24355711	2014
Maintenance therapy with autologous cytokine-induced killer cells in patients with advanced epithelial ovarian cancer after first-line treatment. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 24509174	2014
Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. International journal of oncology\| PubMed ID: 25901533	2015
High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26113410	2015
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis. Cancer biology & medicine\| PubMed ID: 26175928	2015
IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review). International journal of oncology\| PubMed ID: 26548401	2016
Human umbilical cord mesenchymal stem cells delivering sTRAIL home to lung cancer mediated by MCP-1/CCR2 axis and exhibit antitumor effects. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 26733169	2016
Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer. Oncotarget\| PubMed ID: 27223258	2016
Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients. Oncotarget\| PubMed ID: 27283895	2016
Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma. Oncotarget\| PubMed ID: 27835574	2016
Suppression of T cells by myeloid-derived suppressor cells in cancer. Human immunology\| PubMed ID: 27939507	2017
Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment. Frontiers in immunology\| PubMed ID: 28228755	2017
Expression of GARP Is Increased in Tumor-Infiltrating Regulatory T Cells and Is Correlated to Clinicopathology of Lung Cancer Patients. Frontiers in immunology\| PubMed ID: 28261204	2017
Cytokine-Induced Killer Cells Modulates Resistance to Cisplatin in the A549/DDP Cell Line. Journal of Cancer\| PubMed ID: 29158802	2017
Herceptin Enhances the Antitumor Effect of Natural Killer Cells on Breast Cancer Cells Expressing Human Epidermal Growth Factor Receptor-2. Frontiers in immunology\| PubMed ID: 29163501	2017
Interleukin-6 -Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer. Frontiers in immunology\| PubMed ID: 29326716	2017
A novel MDSC-induced PD-1PD-L1 B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties. Oncoimmunology\| PubMed ID: 29632731	2018
Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepa... Oncoimmunology\| PubMed ID: 29900041	2018
SOCS3 Suppression Promoted the Recruitment of CD11bGr-1F4/80MHCII Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion Affecting Myeloid Differe... Frontiers in immunology\| PubMed ID: 30083161	2018
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma. The Journal of experimental medicine\| PubMed ID: 30733283	2019
Memory stem T cells generated by Wnt signaling from blood of human renal clear cell carcinoma patients. Cancer biology & medicine\| PubMed ID: 31119051	2019
Cryoablation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Oncotarget\| PubMed ID: 31289616	2019
Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma. Cancer letters\| PubMed ID: 31705929	2020
Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer. Oncogene\| PubMed ID: 32398867	2020
Expression level of PD-L1 is involved in ALDH1A1-mediated poor prognosis in patients with head and neck squamous cell carcinoma. Pathology, research and practice\| PubMed ID: 32825960	2020
Morphine-3-glucuronide upregulates PD-L1 expression TLR4 and promotes the immune escape of non-small cell lung cancer. Cancer biology & medicine\| PubMed ID: 33628591	2021
Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial-mesenchymal transition and stem-like reprogram. Aging\| PubMed ID: 33744858	2021
Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and Expanded iTregs. Frontiers in immunology\| PubMed ID: 33868236	2021
Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1PD-L1 Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer. Cell death & disease\| PubMed ID: 33967272	2021
Molecular subtypes based on CNVs related gene signatures identify candidate prognostic biomarkers in lung adenocarcinoma. Neoplasia (New York, N.Y.)\| PubMed ID: 34139453	2021
The prognostic landscape of genes and infiltrating immune cells in cytokine induced killer cell treated-lung squamous cell carcinoma and adenocarcinoma. Cancer biology & medicine\| PubMed ID: 34459571	2021
EZH2 identifies the precursors of human natural killer cells with trained immunity. Cancer biology & medicine\| PubMed ID: 34553850	2021
Downregulation of PD-L1 and HLA-I in non-small cell lung cancer with ALK fusion. Thoracic cancer\| PubMed ID: 35253386	2022
CD4 T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer. Cell death & disease\| PubMed ID: 35523765	2022
Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD+CD+ NKT-Like Cells. Journal of oncology\| PubMed ID: 35783158	2022
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC). Cell death & disease\| PubMed ID: 35831283	2022
Rational pemetrexed combined with CIK therapy plus anti-PD-1 mAbs administration sequence will effectively promote the efficacy of CIK therapy in non-small cell lung cancer. Cancer gene therapy\| PubMed ID: 36352092	2023
SOCS3 deficiency-dependent autophagy repression promotes the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway. Journal of leukocyte biology\| PubMed ID: 36808484	2023
[Study on the Biological Function of Abemecilib in Inhibiting the Proliferation, Invasion and Migration of Small Cell Lung Cancer with High c-Myc Expression]. Zhongguo fei ai za zhi = Chinese journal of lung cancer\| PubMed ID: 36872049	2023
DC101, an anti-VEGFR2 agent, promotes high-endothelial venule formation and immune infiltration versus SAR131675 and fruquintinib. Biochemical and biophysical research communications\| PubMed ID: 37084488	2023
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer. Technology in cancer research & treatment\| PubMed ID: 37728201	2023
Blocking Tim-3 enhances the anti-tumor immunity of STING agonist ADU-S100 by unleashing CD4 T cells through regulating type 2 conventional dendritic cells. Theranostics\| PubMed ID: 37771774	2023
Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer. Journal of leukocyte biology\| PubMed ID: 37931147	2024
Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic ac... Clinical and translational medicine\| PubMed ID: 37965796	2023
The spatial landscape of T cells in the microenvironment of stage III lung adenocarcinoma. The Journal of pathology\| PubMed ID: 38361487	2024
Anlotinib and anti-PD-1 mAbs perfected CIK cell therapy for lung adenocarcinoma in preclinical trials. Journal of leukocyte biology\| PubMed ID: 38373017	2024
Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma. Frontiers in immunology\| PubMed ID: 38384466	2024
PGAM1 suppression remodels the tumor microenvironment in triple-negative breast cancer and synergizes with anti-PD-1 immunotherapy. Journal of leukocyte biology\| PubMed ID: 38478709	2024
Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer. Frontiers in immunology\| PubMed ID: 38500886	2024
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2 macrophages. Cancer gene therapy\| PubMed ID: 38750301	2024
Targeted sequencing of DNA/RNA combined with radiomics predicts lymph node metastasis of papillary thyroid carcinoma. Cancer imaging : the official publication of the International Cancer Imaging Society\| PubMed ID: 38886866	2024
Corrigendum: Intratumor tertiary lymphatic structure evaluation predicts the prognosis and immunotherapy response of patients with colorectal cancer. Frontiers in immunology\| PubMed ID: 38947311	2024
Establishment of an animal model of immune-related adverse events induced by immune checkpoint inhibitors. Cancer medicine\| PubMed ID: 39001676	2024
Novel FABP4C1q macrophages enhance antitumor immunity and associated with response to neoadjuvant pembrolizumab and chemotherapy in NSCLC via AMPK/JAK/STAT axis. Cell death & disease\| PubMed ID: 39353883	2024
A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial. Cancer cell\| PubMed ID: 39406186	2024