Jihui Hao

Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital

Affiliated withTianjin Medical University Cancer Institute and Hospital

Research Area

Biography

Jing Hao is a post-doctoral fellow at Cancer Biology Department of Lerner Institute in Cleveland Clinic, USA. She studied Clinical Medicine in China and graduated in 1997 with a MD from Xiangya medical school in Changsha, Hunan Province, China. She was enrolled as a Ph.D. candidate in Toxicology program at Rutgers University in New Jersey USA at 2003. She finished her dissertation on esophageal adenocarcinoma chemoprevention study in 2008 and obtained her Ph.D. later the same year. As a post-doctoral fellow she was previously trained in NCI-Frederick and the George Washington University.

Jing Hao is interested in explore the molecular events in carcinogenesis, therapy resistance and translate the basic research of cancer into clinically relevant therapeutic measures.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Tumor rupture predicts early metastasis and poor prognosis in stage III soft tissue sarcomas. World journal of surgery\| PubMed ID: 21331475	2011
Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer. Cancer biology & therapy\| PubMed ID: 21709439	2011
Regional intra-arterial vs. systemic chemotherapy for advanced pancreatic cancer: a systematic review and meta-analysis of randomized controlled trials. PloS one\| PubMed ID: 22815840	2012
Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene. PloS one\| PubMed ID: 22952674	2012
The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma. Journal of cellular biochemistry\| PubMed ID: 23857671	2013
Contrast enhanced ultrasonography prediction of cystic renal mass in comparison to histopathology. Clinical hemorheology and microcirculation\| PubMed ID: 24165574	2014
The hypoxia-inducible factor-1 regulates the microRNA185 expression through binding to hypoxia response elements sequence 2. Medical oncology (Northwood, London, England)\| PubMed ID: 24198204	2013
Clinical and Prognostic Significance of Coagulation Assays in Pancreatic Cancer Patients With Absence of Venous Thromboembolism. American journal of clinical oncology\| PubMed ID: 24401666	2015
Prostate-specific membrane antigen as a marker of pancreatic cancer cells. Medical oncology (Northwood, London, England)\| PubMed ID: 24477651	2014
Resection or cryosurgery relates with pancreatic tumor type: primary pancreatic cancer with previous non-pancreatic cancer or secondary metastatic cancer within the pancreas. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 24555980	2014
Hypoxia-inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin. Cancer research\| PubMed ID: 24599125	2014
CypA, a gene downstream of HIF-1α, promotes the development of PDAC. PloS one\| PubMed ID: 24662981	2014
[Effects of dioscin on apoptosis in pancreatic cancer MiaPaCa-2 cells and its mechanism]. Zhonghua zhong liu za zhi [Chinese journal of oncology]\| PubMed ID: 24685079	2014
Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection. Carcinogenesis\| PubMed ID: 25086759	2014
Pancreaticoduodenectomy and pancreaticoduodenectomy combined with superior mesenteric-portal vein resection for elderly cancer patients. Hepatobiliary & pancreatic diseases international : HBPD INT\| PubMed ID: 25100129	2014
The clinical significance and regulation mechanism of hypoxia-inducible factor-1 and miR-191 expression in pancreatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine\| PubMed ID: 25119596	2014
Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells. Cancer letters\| PubMed ID: 25130171	2014
LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. Cancer research\| PubMed ID: 25385028	2015
Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget\| PubMed ID: 25544770	2015
Zinc-triggered hydrogelation of self-assembled small molecules to inhibit bacterial growth. Scientific reports\| PubMed ID: 25583430	2015
Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. Biomaterials\| PubMed ID: 25678112	2015
Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells. Medical oncology (Northwood, London, England)\| PubMed ID: 25731618	2015
Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation. Scientific reports\| PubMed ID: 25739554	2015
SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression. PloS one\| PubMed ID: 25799412	2015
Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray. Pathology oncology research : POR\| PubMed ID: 25907256	2015
Should a standard lymphadenectomy during pancreatoduodenectomy exclude para-aortic lymph nodes for all cases of resectable pancreatic head cancer? A consensus statement by the Chinese Study ... International journal of oncology\| PubMed ID: 26314752	2015
Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma. Oncotarget\| PubMed ID: 26315113	2015
XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma. Cancer science\| PubMed ID: 26383967	2015
HIF-1 is a critical target of pancreatic cancer. Oncoimmunology\| PubMed ID: 26405594	2015
The clinical utility of CA125/MUC16 in pancreatic cancer: A consensus of diagnostic, prognostic and predictive updates by the Chinese Study Group for Pancreatic Cancer (CSPAC). International journal of oncology\| PubMed ID: 26718269	2016
An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer. ACS applied materials & interfaces\| PubMed ID: 26759926	2016
Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes. Oncotarget\| PubMed ID: 26872370	2016
Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma. Cancer letters\| PubMed ID: 27212442	2016
Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy. Biomaterials\| PubMed ID: 27343466	2016
IGFBP2 Activates the NF-κB Pathway to Drive Epithelial-Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 27659045	2016
Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. The Journal of biological chemistry\| PubMed ID: 27879315	2016
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin. Cancer research\| PubMed ID: 27923832	2017
Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression. Nature communications\| PubMed ID: 28102193	2017
HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma. Cancer letters\| PubMed ID: 28153790	2017
Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer. International journal of molecular sciences\| PubMed ID: 28333072	2017
A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. Cancer letters\| PubMed ID: 28576749	2017
Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy. ACS nano\| PubMed ID: 28806504	2017
Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice. Gastroenterology\| PubMed ID: 28989066	2018
Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment. Biomaterials\| PubMed ID: 29275122	2018
A new combined criterion to better predict malignant lesions in patients with pancreatic cystic neoplasms. Cancer biology & medicine\| PubMed ID: 29545970	2018
Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth. ACS nano\| PubMed ID: 30676731	2019
LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30679163	2019
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma. The Journal of experimental medicine\| PubMed ID: 30733283	2019
RETRACTED: HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma. Cancer letters\| PubMed ID: 30922919	2019
Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell reports\| PubMed ID: 31509745	2019
Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget\| PubMed ID: 31565190	2019
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma. EMBO molecular medicine\| PubMed ID: 31633874	2019
IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer. Theranostics\| PubMed ID: 32226541	2020
PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC. Signal transduction and targeted therapy\| PubMed ID: 32300119	2020
Dedifferentiation of Epithelial Cells Incorporates Immune Reprogramming. Trends in cell biology\| PubMed ID: 33593679	2021
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4. Gut\| PubMed ID: 33674341	2022
Delta HU is a potential marker to predict chemotherapy response for unresectable pancreatic ductal adenocarcinoma. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]\| PubMed ID: 33712388	2021
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 33763996	2021
PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer. Cancer letters\| PubMed ID: 34052329	2021
Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer. Cancer biology & medicine\| PubMed ID: 34086429	2021
CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms. Cancer letters\| PubMed ID: 34302921	2021
Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer letters\| PubMed ID: 34303764	2021
VannoPortal: multiscale functional annotation of human genetic variants for interrogating molecular mechanism of traits and diseases. Nucleic acids research\| PubMed ID: 34570217	2022
Corrigendum to "Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer" [Biomaterials 46 (2015) 13-25]. Biomaterials\| PubMed ID: 34890971	2022
BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation. Gastroenterology\| PubMed ID: 34951995	2022
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma. Cell discovery\| PubMed ID: 35165277	2022
SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC. International journal of biological sciences\| PubMed ID: 35173526	2022
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin. Genome biology\| PubMed ID: 35227284	2022
Perioperative Serum Scoring Systems Predict Early Recurrence and Poor Prognosis of Resectable Pancreatic Cancer. Frontiers in oncology\| PubMed ID: 35265528	2022
Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. Cancer research\| PubMed ID: 35413105	2022
A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination. Molecular cell\| PubMed ID: 35597237	2022
Robotic Distal Pancreatectomy, a Novel Standard of Care? Benchmark Values for Surgical Outcomes from 16 International Expert Centers. Annals of surgery\| PubMed ID: 35861061	2022
Genome-wide CRISPR screen identifies MTA3 as an inducer of gemcitabine resistance in pancreatic ductal adenocarcinoma. Cancer letters\| PubMed ID: 35981571	2022
ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour-stromal IL-1β/NF-κB/ESE3 signalling axis. British journal of cancer\| PubMed ID: 35986089	2022
Comparison of the long-term outcomes of patients with hepatocellular carcinoma within the Milan criteria treated by ablation, resection, or transplantation. Cancer medicine\| PubMed ID: 36016484	2023
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A. Cell & bioscience\| PubMed ID: 36371321	2022
CD73, a Promising Therapeutic Target of Diclofenac, Promotes Metastasis of Pancreatic Cancer through a Nucleotidase Independent Mechanism. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 36563135	2023
The relevance between hypoxia-dependent spatial transcriptomics and the prognosis and efficacy of immunotherapy in claudin-low breast cancer. Frontiers in immunology\| PubMed ID: 36685583	2022
Retraction notice to "HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma" [Cancer Lett. 453 (2019) 10-20]. Cancer letters\| PubMed ID: 36813650	2023
SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation. Gut\| PubMed ID: 36828627	2023
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Nature communications\| PubMed ID: 36869052	2023
Survival outcomes of neoadjuvant therapy followed by radical resection versus upfront surgery for stage I-III pancreatic ductal adenocarcinoma: a retrospective cohort study. International journal of surgery (London, England)\| PubMed ID: 37132194	2023
Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis. Journal of experimental & clinical cancer research : CR\| PubMed ID: 37143164	2023
Selective extended dissection for pancreaticoduodenectomy is associated with better survival in pancreatic cancer patients: retrospective cohort study. International journal of surgery (London, England)\| PubMed ID: 37195787	2023
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma. Cancer biology & medicine\| PubMed ID: 37381714	2023
BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis. Signal transduction and targeted therapy\| PubMed ID: 37443111	2023
The Hippo/YAP signaling pathway: the driver of cancer metastasis. Cancer biology & medicine\| PubMed ID: 37493303	2023
A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma. iScience\| PubMed ID: 37664604	2023
High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast. Frontiers of medicine\| PubMed ID: 37682378	2023
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress. Journal of experimental & clinical cancer research : CR\| PubMed ID: 37697370	2023
Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 37819952	2023
ADAR1 links R-loop homeostasis to ATR activation in replication stress response. Nucleic acids research\| PubMed ID: 37831098	2023
A Novel Bifidobacterium/Klebsiella Ratio in Characterization Analysis of the Gut and Bile Microbiota of CCA Patients. Microbial ecology\| PubMed ID: 38030815	2023
Unraveling the causal genes and transcriptomic determinants of human telomere length. Nature communications\| PubMed ID: 38129441	2023
Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis. Signal transduction and targeted therapy\| PubMed ID: 38177109	2024
Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma. Oncogene\| PubMed ID: 38243080	2024
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis. Molecular cell\| PubMed ID: 38423014	2024
Integrating tertiary lymphoid structure-associated genes into computational models to evaluate prognostication and immune infiltration in pancreatic cancer. Journal of leukocyte biology\| PubMed ID: 38484172	2024
Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2 Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy. Gastroenterology\| PubMed ID: 38492894	2024
EGC enhances tumor antigen presentation and CD8 T cell-mediated antitumor immunity via targeting oncoprotein SND1. Cancer letters\| PubMed ID: 38710299	2024
BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism. Science advances\| PubMed ID: 38896624	2024
Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of pancreatic cancer. Journal of the National Cancer Center\| PubMed ID: 39036552	2022
CD64 fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8 T cells. Gut\| PubMed ID: 39187291	2024
Survival outcomes of adjuvant chemotherapy in patients with stage I pancreatic cancer stratified by pathologic risk. Surgery\| PubMed ID: 39191600	2024
Computational modeling of mast cell tryptase family informs selective inhibitor development. iScience\| PubMed ID: 39280611	2024
A prospective study of neoadjuvant pembrolizumab plus chemotherapy for resectable esophageal squamous cell carcinoma: The Keystone-001 trial. Cancer cell\| PubMed ID: 39406186	2024
Hypoxic and Acidic Tumor Microenvironment-Driven AVL9 Promotes Chemoresistance of Pancreatic Ductal Adenocarcinoma via the AVL9-IκBα-SKP1 Complex. Gastroenterology\| PubMed ID: 39566663	2024
The nuclear condensates of ESE3/EHF induce cellular senescence without the associated inflammatory secretory phenotype in pancreatic ductal adenocarcinoma. Cancer letters\| PubMed ID: 39710057	2024