John Turchi

Department of Medicine, Indiana University School of Medicine

Affiliated withIndiana University School of Medicine Indiana University School of Medicine

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Pre-steady-state binding of damaged DNA by XPC-hHR23B reveals a kinetic mechanism for damage discrimination. Biochemistry\| PubMed ID: 16460043	2006
Nitric oxide and cisplatin resistance: NO easy answers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537366	2006
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. The Journal of biological chemistry\| PubMed ID: 16537541	2006
Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology. Cell research\| PubMed ID: 18166981	2008
ATM mediates repression of DNA end-degradation in an ATP-dependent manner. DNA repair\| PubMed ID: 18207464	2008
DNA-dependent conformational changes in the Ku heterodimer. Biochemistry\| PubMed ID: 18355052	2008
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic acids research\| PubMed ID: 18515838	2008
Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric ... The Journal of biological chemistry\| PubMed ID: 19329795	2009
Molecular analysis of Ku redox regulation. BMC molecular biology\| PubMed ID: 19715578	2009
Intrinsic hTRF1 fluorescence quenching reveals details of telomere DNA binding activity: impact of DNA length, structure and position of telomeric repeats. Archives of biochemistry and biophysics\| PubMed ID: 19887064	2010
Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct. Biochemistry\| PubMed ID: 20028083	2010
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA repair\| PubMed ID: 20347402	2010
Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function. Cancer research\| PubMed ID: 20395205	2010
Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS chemical biology\| PubMed ID: 20662484	2010
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxidants & redox signaling\| PubMed ID: 20698792	2011
Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy. Antioxidants & redox signaling\| PubMed ID: 20812782	2011
Targeting the OB-Folds of Replication Protein A with Small Molecules. Journal of nucleic acids\| PubMed ID: 21188165	2010
Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability. Antioxidants & redox signaling\| PubMed ID: 21235357	2011
Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase. Molecular cancer therapeutics\| PubMed ID: 21330459	2011
Identification of Mre11 as a target for heat radiosensitization. Radiation research\| PubMed ID: 21699368	2011
Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin. Molecular cancer therapeutics\| PubMed ID: 21846830	2011
DNA repair: from genome maintenance to biomarker and therapeutic target. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21908578	2011
Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80. International journal of biochemistry and molecular biology\| PubMed ID: 22509479	2012
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways. The Journal of biological chemistry\| PubMed ID: 22621925	2012
Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer biology & therapy\| PubMed ID: 23380594	2013
Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 23730209	2013
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma. Biochemical and biophysical research communications\| PubMed ID: 24041688	2013
Exploring a structural protein-drug interactome for new therapeutics in lung cancer. Molecular bioSystems\| PubMed ID: 24402119	2014
Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Molecular and cellular biology\| PubMed ID: 24687855	2014
Testing the metal of ERCC2 in predicting the response to platinum-based therapy. Cancer discovery\| PubMed ID: 25274682	2014
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25316809	2014
Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochemical pharmacology\| PubMed ID: 25449597	2015
Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit. PloS one\| PubMed ID: 25978375	2015
DNA repair targeted therapy: The past or future of cancer treatment? Pharmacology & therapeutics\| PubMed ID: 26896565	2016
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA repair\| PubMed ID: 26991853	2016
Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction. Journal of medicinal chemistry\| PubMed ID: 28933851	2017
Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells. Radiation research\| PubMed ID: 29763378	2018
Small-Molecule Inhibitor Screen for DNA Repair Proteins. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31127579	2019
Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors. ACS medicinal chemistry letters\| PubMed ID: 32550990	2020
Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer. Molecular cancer research : MCR\| PubMed ID: 32801161	2020
Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction. Nucleic acids research\| PubMed ID: 33119767	2020
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Molecular cell\| PubMed ID: 34216544	2021
OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy. Cancers\| PubMed ID: 34283091	2021
Characterization and initial demonstration of efficacy of a novel heat-activated metalloenediyne anti-cancer agent. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 35236209	2022
Targeting Replication Protein A for Cancer Therapy. Frontiers in oncology\| PubMed ID: 35251993	2022
Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair. Frontiers in oncology\| PubMed ID: 35463312	2022
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response. ChemMedChem\| PubMed ID: 36054918	2022
Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases. Frontiers in oncology\| PubMed ID: 36237323	2022
ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe. NAR cancer\| PubMed ID: 36644397	2023
Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks. NAR cancer\| PubMed ID: 36755959	2023
The mechanistic role of cardiac glycosides in DNA damage response and repair signaling. Cellular and molecular life sciences : CMLS\| PubMed ID: 37584722	2023
The Effect of Replication Protein A Inhibition and Post-Translational Modification on ATR Kinase Signaling. Research square\| PubMed ID: 39108493	2024
The effect of replication protein A inhibition and post-translational modification on ATR kinase signaling. Scientific reports\| PubMed ID: 39187637	2024
Impact of Optimized Ku-DNA Binding Inhibitors on the Cellular and In Vivo DNA Damage Response. Cancers\| PubMed ID: 39409907	2024