acquisition-semi-automated-analysis-respiratory-muscle-surface

Acquisition and Semi-Automated Analysis of Respiratory Muscle Surface Electromyography

Evaluating respiratory drive presents challenges due to the obtrusiveness and impracticality of current methods like functional magnetic resonance imaging ...

University of Toronto, University Health Network

University Health Network

Lung transplant candidates and recipients have significant impairments in skeletal muscle mass, strength and function--individual measures of sarcopenia. Skeletal muscle dysfunction has been observed in the pre-transplant and post-transplant period and could have an important effect on transplant outcomes. A systematic review was performed to characterize the techniques used to study sarcopenia and assess the level of impairment throughout the transplant process. Electronic databases were searched (inception to July 2013) for prospective studies measuring at least 1 element of sarcopenia (muscle mass, strength, or function) in lung transplant patients. Eighteen studies were included, and study quality was assessed using the Downs and Black scale. A variety of measurements were used to evaluate sarcopenia in 694 lung transplant patients. Muscle mass in 7 studies was assessed using bioelectrical impedance (n = 4), computed tomography or magnetic resonance imaging (n = 2), or skin folds (n = 1), and was significantly reduced. Quadriceps strength was examined in 14 studies with computerized dynamometer (n = 10) and hand-held dynamometer (n = 4). Quadriceps strength was reduced in the pre-transplant period (mean range, 49%-86% predicted; n = 455 patients), further reduced immediately after transplant (51%-72%, n = 126), and improved beyond 3 months after transplant (58%-101%, n = 164). Only 2 studies measured lower extremity function (sit-to-stand test). A multitude of measurement techniques have been used to assess individual measures of sarcopenia, with reduced muscle mass and quadriceps strength observed in the pre-transplant and post-transplant period. Further standardization of measurement techniques is needed to assess the clinical effect of sarcopenia in lung transplantation.

Sarcopenia in lung transplantation: a systematic review.

Pulmonary endarterectomy (PEA) is a curative procedure for patients with chronic thromboembolic pulmonary hypertension. Body composition and exercise capacity have been associated with adverse outcomes in patients undergoing cardiothoracic operations, but their significance with PEA is unclear. We evaluated the association of body composition and 6-minute walk distance (6MWD) with disease severity, hospital length of stay, discharge disposition, and postoperative functional recovery.

Clinical Implications of Body Composition and Exercise Capacity Following Pulmonary Endarterectomy.

Looking Beyond BMI Classifications With Complementary Assessment of Body Composition in COPD.

Pulmonary inhaler therapy is a core treatment modality for >600 million individuals affected by obstructive airways disease globally. Poor inhaler technique is associated with reduced disease control and increased health care utilization; however, many patients rely on the internet as a technical resource. This study assesses the content and quality of online resources describing inhaler techniques.

A comprehensive evaluation of online inhaler use techniques for obstructive airway disease.

Cognitive and physical limitations are common in individuals with chronic lung diseases, but their interactions with physical function and activities of daily living are not well characterized. Understanding these interactions and potential contributors may provide insights on disability and enable more tailored rehabilitation strategies.

Translating the Interplay of Cognition and Physical Performance in COPD and Interstitial Lung Disease: Meeting Report and Literature Review.

Pulmonary rehabilitation (PR) guidelines support the efficacy and safety of supervised exercise training in mild-moderate pulmonary arterial hypertension (PAH). However, the exercise training response and safety of PR in PAH lung transplant (LTx) candidates has not been described.

Article	Year
Sarcopenia in lung transplantation: a systematic review. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 25044057	2014
Clinical Implications of Body Composition and Exercise Capacity Following Pulmonary Endarterectomy. The Annals of thoracic surgery\| PubMed ID: 33667463	2022
Looking Beyond BMI Classifications With Complementary Assessment of Body Composition in COPD. Chest\| PubMed ID: 37164566	2023
A comprehensive evaluation of online inhaler use techniques for obstructive airway disease. Respiratory medicine\| PubMed ID: 38548142	2024
Translating the Interplay of Cognition and Physical Performance in COPD and Interstitial Lung Disease: Meeting Report and Literature Review. Chest\| PubMed ID: 38901488	2024
Pulmonary rehabilitation in lung transplant candidates with pulmonary arterial hypertension. Respiratory medicine\| PubMed ID: 39321999	2024

Dmitry Rozenberg

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