Laurent Brochard

Keenan Centre for Biomedical Research, Unity Health Toronto

Affiliated withUnity Health Toronto University of Toronto

Research Area

Biography

Laurent Brochard has not added Biography.
If you are Laurent Brochard and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? The Lancet. Respiratory medicine\| PubMed ID: 32645311	2020
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive care medicine\| PubMed ID: 33201321	2020
Automated detection and quantification of reverse triggering effort under mechanical ventilation. Critical care (London, England)\| PubMed ID: 33588912	2021
Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Critical care (London, England)\| PubMed ID: 33726819	2021
Guideline-directed management of COVID-19: Do's and Don'ts. The European respiratory journal\| PubMed ID: 33766949	2021
Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study. Chest\| PubMed ID: 34090872	2021
A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea. Annals of intensive care\| PubMed ID: 34250563	2021
Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function. Science translational medicine\| PubMed ID: 34524862	2021
One-Year Readmission Following Undifferentiated Acute Hypercapnic Respiratory Failure. COPD\| PubMed ID: 34657539	2021
Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis. Annals of intensive care\| PubMed ID: 34693485	2021
How to avoid an epidemic of endotracheal tube occlusion. The Lancet. Respiratory medicine\| PubMed ID: 34739886	2021
The Pressure Paradox: Abdominal Compression to Detect Lung Hyperinflation in COVID-19 Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine\| PubMed ID: 34748470	2022
Reliability of plateau pressure during patient-triggered assisted ventilation. Analysis of a multicentre database. Journal of critical care\| PubMed ID: 34952477	2022
Advancing Global Respiratory Health, Sleep, and Critical Care: Editorial from the New Team. American journal of respiratory and critical care medicine\| PubMed ID: 34971340	2022
Risks and Benefits of Ultra-Lung-Protective Invasive Mechanical Ventilation Strategies with a Focus on Extracorporeal Support. American journal of respiratory and critical care medicine\| PubMed ID: 35044901	2022
Setting and Titrating Positive End-Expiratory Pressure. Chest\| PubMed ID: 35131298	2022
Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients. Annals of intensive care\| PubMed ID: 35150355	2022
Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis... American journal of respiratory and critical care medicine\| PubMed ID: 35180042	2022
Phrenic Nerve Block and Respiratory Effort in Pigs and Critically Ill Patients with Acute Lung Injury. Anesthesiology\| PubMed ID: 35348581	2022
High flow nasal cannula improves breathing efficiency and ventilatory ratio in COPD patients recovering from an exacerbation. Journal of critical care\| PubMed ID: 35349909	2022
Corrigendum to "Reliability of plateau pressure during patient-triggered assisted ventilation. Analysis of a multicentre database" [Journal of Critical Care, 68 (2022) 96-103]. Journal of critical care\| PubMed ID: 35379532	2022
External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study. Annals of intensive care\| PubMed ID: 35412161	2022
Physiology Is Vital to Precision Medicine in Acute Respiratory Distress Syndrome and Sepsis. American journal of respiratory and critical care medicine\| PubMed ID: 35442864	2022
Lung recruitment. Intensive care medicine\| PubMed ID: 35499759	2022
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive care medicine\| PubMed ID: 35670818	2022
The physiological underpinnings of life-saving respiratory support. Intensive care medicine\| PubMed ID: 35690953	2022
The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. Critical care (London, England)\| PubMed ID: 35739553	2022
Noninvasive respiratory support in intensive care medicine. Intensive care medicine\| PubMed ID: 35759009	2022
Asymmetrical Lung Injury: Management and Outcome. Seminars in respiratory and critical care medicine\| PubMed ID: 35785812	2022
Correction to: Noninvasive respiratory support in intensive care medicine. Intensive care medicine\| PubMed ID: 35916914	2022
Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy. EBioMedicine\| PubMed ID: 35952495	2022
Do Thresholds for Invasive Ventilation in Hypoxemic Respiratory Failure Exist? A Cohort Study. American journal of respiratory and critical care medicine\| PubMed ID: 36150166	2023
Early Variation of ROX Index Predicts High-Flow Nasal Cannula Outcome in Awake Subjects With Severe Hypoxemic COVID-19. Respiratory care\| PubMed ID: 36167850	2023
Noninvasive Respiratory Support for Adults with Acute Respiratory Failure. The New England journal of medicine\| PubMed ID: 36322846	2022
Mechanical Ventilation in ARDS With an Automatic Resuscitator. Respiratory care\| PubMed ID: 36368776	2023
Reverse Triggering during Controlled Ventilation: From Physiology to Clinical Management. American journal of respiratory and critical care medicine\| PubMed ID: 36470240	2023
Reply to Wennen : Interpretation of Diaphragmatic Force Measurements in Reverse Triggering in a Porcine Model. American journal of respiratory and critical care medicine\| PubMed ID: 36493770	2023
Possible overestimation of chest wall driving pressure and underestimation of airway closure. Author's reply. Intensive care medicine\| PubMed ID: 36629880	2023
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. The Lancet. Respiratory medicine\| PubMed ID: 36693401	2023
Correction: Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive care medicine\| PubMed ID: 36729185	2023
Introducing "Viewpoint: Turning the Air Blue". American journal of respiratory and critical care medicine\| PubMed ID: 36753677	2023
Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts. Critical care (London, England)\| PubMed ID: 36814287	2023
Magnitude of Synchronous and Dyssynchronous Inspiratory Efforts during Mechanical Ventilation: A Novel Method. American journal of respiratory and critical care medicine\| PubMed ID: 36848505	2023
WEAN SAFE and the definition of the first separation attempt - Authors' reply. The Lancet. Respiratory medicine\| PubMed ID: 36934737	2023
Limiting Dynamic Driving Pressure in Patients Requiring Mechanical Ventilation. Critical care medicine\| PubMed ID: 36971437	2023
Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials\| PubMed ID: 36973743	2023
Association of lung recruitment and change in recruitment-to-inflation ratio from supine to prone position in acute respiratory distress syndrome. Critical care (London, England)\| PubMed ID: 37055792	2023
First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study. Intensive care medicine experimental\| PubMed ID: 37081235	2023
Lung Recruitment Assessed by Electrical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine\| PubMed ID: 37097986	2023
Physical manoeuvres in patients with ARDS and low compliance: bedside approaches to detect lung hyperinflation and optimise mechanical ventilation. The European respiratory journal\| PubMed ID: 37208034	2023
Mechanical Ventilation: Negative to Positive and Back Again. Critical care clinics\| PubMed ID: 37230549	2023
Mechanical Ventilation after Traumatic Spinal Cord Injury-A Multicentric Cohort Study-based Prediction Model for Weaning Success: The BICYCLE Score. Annals of the American Thoracic Society\| PubMed ID: 37236632	2023
Tidal lung hysteresis to interpret PEEP-induced changes in compliance in ARDS patients. Critical care (London, England)\| PubMed ID: 37312187	2023
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive care medicine\| PubMed ID: 37326646	2023
Reply to Jimenez and Hyzy and to Le Stang and Dres. American journal of respiratory and critical care medicine\| PubMed ID: 37387595	2023
The Use of the Oxygenation Stretch Index to Predict Outcomes in Mechanically Ventilated Patients With COVID-19 ARDS. Respiratory care\| PubMed ID: 37402585	2023
Bronchodilator Efficacy of High-Flow Nasal Cannula in COPD: Vibrating Mesh Nebulizer Versus Jet Nebulizer. Respiratory care\| PubMed ID: 37607815	2024
Precision Medicine Using Simultaneous Monitoring and Assessment with Imaging and Biomarkers to Manage Mechanical Ventilation in ARDS. Intensive care research\| PubMed ID: 37664686	2023
Sonometric assessment of cough predicts extubation failure: SonoWean-a proof-of-concept study. Critical care (London, England)\| PubMed ID: 37749612	2023
Airway Closure in Patients With Cardiogenic Pulmonary Edema as a Cause of Driving Pressure Overestimation: The "Uncorking Effect". Chest\| PubMed ID: 37945193	2023
High flow nasal catheter therapy versus non-invasive positive pressure ventilation in acute respiratory failure (RENOVATE trial): protocol and statistical analysis plan. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine\| PubMed ID: 38046839	2022
A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. bioRxiv : the preprint server for biology\| PubMed ID: 38076980	2023
Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury. Intensive care medicine experimental\| PubMed ID: 38109016	2023
Pendelluft in hypoxemic patients resuming spontaneous breathing: proportional modes versus pressure support ventilation. Annals of intensive care\| PubMed ID: 38117367	2023
Electrical Impedance Tomography to Monitor Hypoxemic Respiratory Failure. American journal of respiratory and critical care medicine\| PubMed ID: 38127779	2024
The Failure of Extracorporeal Carbon Dioxide Removal May Be a Failure of Technology. American journal of respiratory and critical care medicine\| PubMed ID: 38190699	2024
Noninvasive Ventilation Before Intubation and Mortality in Patients Receiving Extracorporeal Membrane Oxygenation for COVID-19: An Analysis of the Extracorporeal Life Support Organization Re... ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 38237635	2024
Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial - A Randomized Clinical Trial. American journal of respiratory and critical care medicine\| PubMed ID: 38261630	2024
Critical Care: A Special Issue of the Blue Journal. American journal of respiratory and critical care medicine\| PubMed ID: 38300147	2024
Ultrasound Evaluation of Parasternal Intercostal, Diaphragm Activity, and Their Ratio in Male Patients with Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine\| PubMed ID: 38319129	2024
Limiting Overdistention or Collapse When Mechanically Ventilating Injured Lungs: A Randomized Study in a Porcine Model. American journal of respiratory and critical care medicine\| PubMed ID: 38354065	2024
Noninvasive Electromagnetic Phrenic Nerve Stimulation in Critically Ill Patients: A Feasibility Study. Chest\| PubMed ID: 38403186	2024
Measuring patient's effort on the ventilator. Intensive care medicine\| PubMed ID: 38436722	2024
Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques. Critical care (London, England)\| PubMed ID: 38486268	2024
Critical Care: A Second Special Issue of the Blue Journal. American journal of respiratory and critical care medicine\| PubMed ID: 38501798	2024
Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive care medicine\| PubMed ID: 38512400	2024
Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. Journal of biomedical optics\| PubMed ID: 38532926	2024
An Individual Barrier Enclosure Actively Removing Aerosols for Airborne Isolation: A Vacuum Tent. Respiratory care\| PubMed ID: 38538026	2024
Reply to Tiruvoipati : VENT-AVOID Trial: Avoiding Acute Hypercapnic Respiratory Failure! American journal of respiratory and critical care medicine\| PubMed ID: 38608271	2024
Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation. Critical care (London, England)\| PubMed ID: 38730306	2024
Reverse triggering ? a novel or previously missed phenomenon? Annals of intensive care\| PubMed ID: 38776032	2024
Continuous measurements of respiratory muscle blood flow and oxygen consumption using noninvasive frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 38867669	2024
Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic. JAMA network open\| PubMed ID: 38995645	2024
Prone-position decreases airway closure in a patient with ARDS undergoing venovenous extracorporeal membrane oxygenation. Journal of clinical monitoring and computing\| PubMed ID: 39066871	2024
Reply to Bihari : Alveolar Collapse Is a Threat in Injured Lungs but What About the Airway Opening Pressure. American journal of respiratory and critical care medicine\| PubMed ID: 39133922	2024
Post-insufflation diaphragm contractions in patients receiving various modes of mechanical ventilation. Critical care (London, England)\| PubMed ID: 39294653	2024
Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study. Annals of intensive care\| PubMed ID: 39312044	2024
Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study. Annals of intensive care\| PubMed ID: 39368033	2024
Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion. Intensive care medicine experimental\| PubMed ID: 39432136	2024
Does patient-ventilator asynchrony really matter? Current opinion in critical care\| PubMed ID: 39445589	2025
Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction. Critical care (London, England)\| PubMed ID: 39506755	2024
An International Factorial Vignette-Based Survey of Intubation Decisions in Acute Hypoxemic Respiratory Failure. Critical care medicine\| PubMed ID: 39576153	2025
Fluids Matter in Lung Injury but Not Where We Thought. American journal of respiratory and critical care medicine\| PubMed ID: 39642349	2024
Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction. American journal of respiratory and critical care medicine\| PubMed ID: 39642353	2024
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial. Trials\| PubMed ID: 39736673	2024
Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study. Critical care (London, England)\| PubMed ID: 39773268	2025
Distribution of airway pressure opening in the lungs measured with electrical impedance tomography (POET): a prospective physiological study. Critical care (London, England)\| PubMed ID: 39819779	2025
Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study. Annals of intensive care\| PubMed ID: 39828725	2025