Thomas E. Edwards

Senior Project Leader, Emerald Bio

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2013

Other Publications

Article	Year
Investigation of RNA-protein and RNA-metal ion interactions by electron paramagnetic resonance spectroscopy. The HIV TAR-Tat motif. Chemistry & biology\| PubMed ID: 12079781	2002
Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition. Biochemistry\| PubMed ID: 12475232	2002
Nanometer distance measurements on RNA using PELDOR. Journal of the American Chemical Society\| PubMed ID: 12643697	2003
EPR spectroscopic analysis of TAR RNA-metal ion interactions. Biochemical and biophysical research communications\| PubMed ID: 12659878	2003
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. The EMBO journal\| PubMed ID: 15192703	2004
Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation. Chemistry & biology\| PubMed ID: 15797217	2005
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR. Nucleic acids research\| PubMed ID: 15961729	2005
EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion induced folding. Biochemistry\| PubMed ID: 16171402	2005
Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. Structure (London, England : 1993)\| PubMed ID: 16962976	2006
Riboswitches: small-molecule recognition by gene regulatory RNAs. Current opinion in structural biology\| PubMed ID: 17574837	2007
Site-specific incorporation of nitroxide spin-labels into 2'-positions of nucleic acids. Nature protocols\| PubMed ID: 17703207	2007
Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch. Chemistry & biology\| PubMed ID: 18940672	2008
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase. Nature structural & molecular biology\| PubMed ID: 19234468	2009
Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch. RNA (New York, N.Y.)\| PubMed ID: 19948769	2010
X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. Journal of structural and functional genomics\| PubMed ID: 20364333	2010
Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head. PloS one\| PubMed ID: 20862217	2010
Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C. Nucleic acids research\| PubMed ID: 21252294	2011
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. Journal of structural and functional genomics\| PubMed ID: 21359640	2011
SAD phasing using iodide ions in a high-throughput structural genomics environment. Journal of structural and functional genomics\| PubMed ID: 21359836	2011
Fragment screening of infectious disease targets in a structural genomics environment. Methods in enzymology\| PubMed ID: 21371605	2011
Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry\| PubMed ID: 21870819	2011
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. BMC structural biology\| PubMed ID: 21995815	2011
Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system. Journal of applied crystallography\| PubMed ID: 22477778	2010
Structure of hepatitis C virus polymerase in complex with primer-template RNA. Journal of virology\| PubMed ID: 22496223	2012
Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins. Protein science : a publication of the Protein Society\| PubMed ID: 22544630	2012
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23139410	2012
Combining functional and structural genomics to sample the essential Burkholderia structome. PloS one\| PubMed ID: 23382856	2013
Structural insights into the functional role of the Hcn sub-domain ofÂ the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D. Biochimie\| PubMed ID: 23523511	2013
Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. Journal of structural and functional genomics\| PubMed ID: 23709284	2013