Irena Pastar

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine

Affiliated withUniversity of Miami Miller School of Medicine

Research Area

Biography

Irena Pastar has not added Biography.
If you are Irena Pastar and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2025

Other Publications

Article	Year
Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. The Journal of biological chemistry\| PubMed ID: 19903814	2010
Attenuation of the transforming growth factor beta-signaling pathway in chronic venous ulcers. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 20069132	2010
Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. The Journal of biological chemistry\| PubMed ID: 21239489	2011
Keratin dressings speed epithelialization of deep partial-thickness wounds. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 22332782	2012
Micro-RNAs: New Regulators of Wound Healing. Surgical technology international\| PubMed ID: 22504970	2011
Induction of specific microRNAs inhibits cutaneous wound healing. The Journal of biological chemistry\| PubMed ID: 22773832	2012
Interactions of methicillin resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in polymicrobial wound infection. PloS one\| PubMed ID: 23451098	2013
Quality assessment of tissue specimens for studies of diabetic foot ulcers. Experimental dermatology\| PubMed ID: 23489425	2013
Glucocorticoid receptor localizes to adherens junctions at the plasma membrane of keratinocytes. PloS one\| PubMed ID: 23646206	2013
Increased number of Langerhans cells in the epidermis of diabetic foot ulcers correlates with healing outcome. Immunologic research\| PubMed ID: 24277309	2013
Deregulation of epidermal stem cell niche contributes to pathogenesis of nonhealing venous ulcers. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 24635172	2014
Epithelialization in Wound Healing: A Comprehensive Review. Advances in wound care\| PubMed ID: 25032064	2014
The Role of TGFβ Signaling in Wound Epithelialization. Advances in wound care\| PubMed ID: 25032068	2014
Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing. The Journal of investigative dermatology\| PubMed ID: 26269405	2015
Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin. PloS one\| PubMed ID: 26318001	2015
Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. International journal of molecular sciences\| PubMed ID: 26512657	2015
Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. European journal of medicinal chemistry\| PubMed ID: 26703794	2016
Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. Journal of cellular physiology\| PubMed ID: 26916741	2016
Epithelial-mesenchymal transition in tissue repair and fibrosis. Cell and tissue research\| PubMed ID: 27461257	2016
Biology and Biomarkers for Wound Healing. Plastic and reconstructive surgery\| PubMed ID: 27556760	2016
Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 27607190	2016
MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. Archives of dermatological research\| PubMed ID: 28013372	2017
Stress Signals, Mediated by Membranous Glucocorticoid Receptor, Activate PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure. The Journal of investigative dermatology\| PubMed ID: 28017831	2017
Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5. The Journal of biological chemistry\| PubMed ID: 29158265	2018
Optical coherence tomography for assessment of epithelialization in a human ex vivo wound model. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 29235208	2017
Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers. The Journal of investigative dermatology\| PubMed ID: 29273315	2018
Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 29315980	2017
Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects? Experimental dermatology\| PubMed ID: 29660181	2018
Novel mevalonate kinase missense mutation in a patient with disseminated superficial actinic porokeratosis. JAAD case reports\| PubMed ID: 29693064	2018
Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30088952	2019
Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection. Experimental dermatology\| PubMed ID: 30609079	2019
A tractable, simplified ex vivo human skin model of wound infection. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 30825247	2019
Preclinical evaluation of a novel silver gelling fiber dressing on Pseudomonas aeruginosa in a porcine wound infection model. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 30920083	2019
Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 31409528	2019
Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling. JCI insight\| PubMed ID: 31661463	2019
A bioengineered living cell construct activates metallothionein/zinc/MMP8 and inhibits TGFβ to stimulate remodeling of fibrotic venous leg ulcers. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 31674093	2020
Reply to "Questioning the use of an acute porcine wound model to assess anti-biofilm activity of dressings". Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 32011777	2020
Skin Microbiota and its Interplay with Wound Healing. American journal of clinical dermatology\| PubMed ID: 32914215	2020
Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nature communications\| PubMed ID: 32938916	2020
Boosts Innate Immune Response by Activation of Gamma Delta T Cells and Induction of Perforin-2 in Human Skin. Frontiers in immunology\| PubMed ID: 33042139	2020
Intracellular escape strategies of Staphylococcus aureus in persistent cutaneous infections. Experimental dermatology\| PubMed ID: 33179358	2021
Correlates of injection-related wounds and skin infections amongst persons who inject drugs and use a syringe service programme: A single center study. International wound journal\| PubMed ID: 33586860	2021
Epigenetic regulation of cellular functions in wound healing. Experimental dermatology\| PubMed ID: 33690920	2021
Wounds and Skin and Soft Tissue Infections in People Who Inject Drugs and the Utility of Syringe Service Programs in Their Management. Advances in wound care\| PubMed ID: 33913781	2021
Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro-healing miRNA-mediated epigenetic signature. Experimental dermatology\| PubMed ID: 34114688	2021
Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds. Communications biology\| PubMed ID: 34145387	2021
Corrigendum: Boosts Innate Immune Response by Activation of Gamma Delta T Cells and Induction of Perforin-2 in Human Skin. Frontiers in immunology\| PubMed ID: 34447392	2021
Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression. The Journal of clinical investigation\| PubMed ID: 34730110	2021
Dichotomous role of miR193b-3p in diabetic foot ulcers maintains inhibition of healing and suppression of tumor formation. Science translational medicine\| PubMed ID: 35544594	2022
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers. EMBO reports\| PubMed ID: 35856334	2022
Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets. eLife\| PubMed ID: 35942686	2022
Innate immunity and microbial dysbiosis in hidradenitis suppurativa - vicious cycle of chronic inflammation. Frontiers in immunology\| PubMed ID: 35967376	2022
Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo. eLife\| PubMed ID: 36454035	2022
Chronic wound microenvironment mediates selection of biofilm-forming multi drug resistant with capability to impair healing. Research square\| PubMed ID: 36824891	2023
Novel Diagnostic Technologies and Therapeutic Approaches Targeting Chronic Wound Biofilms and Microbiota. Current dermatology reports\| PubMed ID: 37007641	2022
Cutaneous changes in diabetic patients: Primed for aberrant healing? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 37365017	2023
Calreticulin: a multifunctional protein with potential therapeutic applications for chronic wounds. Frontiers in medicine\| PubMed ID: 37692787	2023
Spatial Distribution and Functional Impact of Human Scalp Hair Follicle Microbiota. The Journal of investigative dermatology\| PubMed ID: 38070726	2024
An Optimized and Advanced Algorithm for the Quantification of Immunohistochemical Biomarkers in Keratinocytes. JID innovations : skin science from molecules to population health\| PubMed ID: 38756235	2024
Postbiotic lactobacilli induce cutaneous antimicrobial response and restore the barrier to inhibit the intracellular invasion of Staphylococcus aureus in vitro and ex vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 39018106	2024
Multi-drug resistant Staphylococcus epidermidis from chronic wounds impair healing in human wound model. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 39439244	2024
Tailored Bioengineering and Nanomedicine Strategies for Sex-Specific Healing of Chronic Wounds. The British journal of dermatology\| PubMed ID: 39565404	2024
The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 39639458	2025