clinical-application-artificial-intelligence-preoperative-planning

Clinical Application of Artificial Intelligence Preoperative Planning System Combined with Expert Database Retrieval in Complex Revision Hip Surgery

Accurate preoperative planning in revision hip arthroplasty is crucial for achieving successful outcomes. To enhance the intuitive evaluation of ...

Henan Provincial Orthopedic Hospital

In the aging population, the decrease on osteogenic differentiation resulted into a significant reduction in bone formation. Bone tissue engineering has been a successful technique for treatment of bone defects. It is reported that adipose-derived stem cells (ADSCs) have pluripotency to differentiate into adipocytes and osteoblasts. However little is revealed about the effect of the herbal medicine Asperosaponin VI (ASA VI) on ADSCs differentiation. In our study, we isolated and identified ADSCs from rats. We examined the effect of different concentrations of ASA VI in ADSCs on alkaline phosphatase (ALP) activity, calcium deposition, the expression of bone-related proteins and the release of inflammatory cytokines. Flowcytometry assay showed ADSCs were highly expressed CD44 and CD105, but hardly expressed CD34 and CD45, suggesting ADSCs were successfully isolated for follow-up experiments. ALP activity examination and Alizarin red (AR) stain showed that ASA VI enhanced the ALP activity and promoted matrix mineralization in ADSCs. In addition, bone-related protein OCN and RUNX2, and Smad2/3 phosphorylation was upregulated after ASA VI treatment in ADSCs. ELISA results showed that ASA VI blocked the release of TNF-α, IL-6 and IL-1β in ADSCs. Considering this results, we concluded that ASA VI promotes osteogenic differentiation of ADSCs through inducing the expression of bone-related proteins. These findings enriched the function of ASA VI as a regenerative medicine and shed new light for the treatment of bone defects in clinical research.

Asperosaponin VI stimulates osteogenic differentiation of rat adipose-derived stem cells.

To discuss a static and permanent spacer in the treatment of chronic periprosthetic knee infection. Methods In this study, patients who were diagonised with chronic periprosthetic knee infection and not appropriate to undergo revision operations were included and were treated with static and permanent spacers. Infection recurrence rate was recorded, Visual Analogue Scale (VAS) score and Knee Society Score (KSS) were used to record patients' pain and knee function before the operation and at the final follow-up (minimum 24 months).

Novel, static, permanent spacers to treat chronic knee periprosthetic joint infections.

To investigate the accuracy, safety, and short-term effectiveness of a domestic robot-assisted system in total knee arthroplasty (TKA) by a multicenter randomized controlled trial.

[A multicenter randomized controlled trial of domestic robot-assisted and conventional total knee arthroplasty].

Balancing weight reduction benefits and risks: implications for serum urate management: comment on the article by Fukui et al.

To analyze the short-term effectiveness and safety of personalized three-dimensional (3D) printed customized prostheses in severe Paprosky type Ⅲ acetabular bone defects.

Article	Year
Asperosaponin VI stimulates osteogenic differentiation of rat adipose-derived stem cells. Regenerative therapy\| PubMed ID: 31193169	2019
Novel, static, permanent spacers to treat chronic knee periprosthetic joint infections. International orthopaedics\| PubMed ID: 37421425	2023
[A multicenter randomized controlled trial of domestic robot-assisted and conventional total knee arthroplasty]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery\| PubMed ID: 37987040	2023
Balancing weight reduction benefits and risks: implications for serum urate management: comment on the article by Fukui et al. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 39633597	2024
[Application of personalized three-dimensional printed customized prostheses in severe Paprosky type acetabular bone defects]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery\| PubMed ID: 39848710	2025

Yongqiang Sun

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