Udo S. Gaipl

Translational Radiobiology, Friedrich-Alexander-Universität Erlangen-Nürnberg

Affiliated withFriedrich-Alexander-Universität Erlangen-Nürnberg Comprehensive Cancer Center Erlangen-EMN

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Low dose ionising radiation leads to a NF-κB dependent decreased secretion of active IL-1β by activated macrophages with a discontinuous dose-dependency. International journal of radiation biology\| PubMed ID: 22545750	2012
How does ionizing irradiation contribute to the induction of anti-tumor immunity? Frontiers in oncology\| PubMed ID: 22848871	2012
Selected anti-tumor vaccines merit a place in multimodal tumor therapies. Frontiers in oncology\| PubMed ID: 23087898	2012
Reduced secretion of the inflammatory cytokine IL-1β by stimulated peritoneal macrophages of radiosensitive Balb/c mice after exposure to 0.5 or 0.7 Gy of ionizing radiation. Autoimmunity\| PubMed ID: 23215648	2013
Antitumor immune responses induced by ionizing irradiation and further immune stimulation. Cancer immunology, immunotherapy : CII\| PubMed ID: 24052136	2014
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines. Radiation oncology (London, England)\| PubMed ID: 24678590	2014
Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy. Immunotherapy\| PubMed ID: 24896628	2014
Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases. Cancer letters\| PubMed ID: 25888451	2015
Radio-immunotherapy: the focused beam expands. The Lancet. Oncology\| PubMed ID: 26095779	2015
The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation. Radiation oncology (London, England)\| PubMed ID: 26383236	2015
Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications. Frontiers in immunology\| PubMed ID: 26500646	2015
Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors. Cancer immunology, immunotherapy : CII\| PubMed ID: 26590829	2016
Primary glioblastoma multiforme tumors and recurrence : Comparative analysis of the danger signals HMGB1, HSP70, and calreticulin. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 26646311	2016
Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 26754406	2016
Erratum to: Primary glioblastoma multiforme tumors and recurrence: comparative analysis of the danger signals HMGB1, HSP70, and calreticulin. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 26809739	2016
[EGFR inhibition in NSCLC tumor cell lines : Influence on cell cycle and tumor control]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 27169393	2016
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer. Oncotarget\| PubMed ID: 27259245	2016
Frequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain. Neuro-oncology\| PubMed ID: 27286796	2016
Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation. Frontiers in oncology\| PubMed ID: 27379203	2016
The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia. Oncoimmunology\| PubMed ID: 27471606	2016
Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry. International journal of molecular sciences\| PubMed ID: 27529227	2016
Cancer Cell Death-Inducing Radiotherapy: Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity. Advances in experimental medicine and biology\| PubMed ID: 27558821	2016
Interconnection between DNA damage, senescence, inflammation, and cancer. Frontiers in bioscience (Landmark edition)\| PubMed ID: 27814618	2017
Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells. Frontiers in immunology\| PubMed ID: 28066420	2016
Modulation of the peripheral immune system after low-dose radon spa therapy: Detailed longitudinal immune monitoring of patients within the RAD-ON01 study. Autoimmunity\| PubMed ID: 28263099	2017
Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors. Frontiers in immunology\| PubMed ID: 28337197	2017
Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases. Frontiers in immunology\| PubMed ID: 28515727	2017
Modulations in the Peripheral Immune System of Glioblastoma Patient Is Connected to Therapy and Tumor Progression-A Case Report from the IMMO-GLIO-01 Trial. Frontiers in neurology\| PubMed ID: 28690586	2017
Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction. Frontiers in immunology\| PubMed ID: 28702024	2017
Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy. Frontiers in immunology\| PubMed ID: 28791026	2017
Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases. Immunological reviews\| PubMed ID: 29027224	2017
[Durvalumab improves prognosis of stage III non-small-cell lung cancer after definitive chemoradiotherapy]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 29374302	2018
Impact of radon and combinatory radon/carbon dioxide spa on pain and hypertension: Results from the explorative RAD-ON01 study. Modern rheumatology\| PubMed ID: 29451048	2019
Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 29500551	2018
Ionizing radiation reduces the capacity of activated macrophages to induce T-cell proliferation, but does not trigger dendritic cell-mediated non-targeted effects. International journal of radiation biology\| PubMed ID: 29912595	2019
Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicology research\| PubMed ID: 30090323	2016
Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism. Frontiers in immunology\| PubMed ID: 30279685	2018
Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints. International journal of molecular sciences\| PubMed ID: 30332826	2018
Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System. International journal of molecular sciences\| PubMed ID: 30428512	2018
Temporarily increased TGFβ following radon spa correlates with reduced pain while serum IL-18 is a general predictive marker for pain sensitivity. Radiation and environmental biophysics\| PubMed ID: 30456560	2019
One-Tube Multicolor Flow Cytometry Assay (OTMA) for Comprehensive Immunophenotyping of Peripheral Blood. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30539471	2019
Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose. Journal of immunology research\| PubMed ID: 31485459	2019
Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment. Frontiers in oncology\| PubMed ID: 31555582	2019
Immune biological rationales for the design of combined radio- and immunotherapies. Cancer immunology, immunotherapy : CII\| PubMed ID: 31953578	2020
Analysis of the immune status from peripheral whole blood with a single-tube multicolor flow cytometry assay. Methods in enzymology\| PubMed ID: 32000906	2020
[Promising results of the combination of radiotherapy and pembrolizumab in metastatic NSCLC]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 32040692	2020
Early Mortality of Brain Cancer Patients and its Connection to Cytomegalovirus Reactivation During Radiochemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 32060103	2020
Olanzapine combined with 5-hydroxytryptamine type 3 receptor antagonist (5-HT3 RA) plus dexamethasone for prevention and treatment of chemotherapy-induced nausea and vomiting in high and mod... ESMO open\| PubMed ID: 32079622	2020
Editorial: Radioimmunotherapy-Translational Opportunities and Challenges. Frontiers in oncology\| PubMed ID: 32154180	2020
Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nature communications\| PubMed ID: 32332732	2020
Differences of the Immune Phenotype of Breast Cancer Cells after Ex Vivo Hyperthermia by Warm-Water or Microwave Radiation in a Closed-Loop System Alone or in Combination with Radiotherapy. Cancers\| PubMed ID: 32349284	2020
Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses. Frontiers in oncology\| PubMed ID: 32596144	2020
Low Dose Radiation Therapy, Particularly with 0.5 Gy, Improves Pain in Degenerative Joint Disease of the Fingers: Results of a Retrospective Analysis. International journal of molecular sciences\| PubMed ID: 32824064	2020
The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts. International journal of molecular sciences\| PubMed ID: 32887421	2020
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8. Journal for immunotherapy of cancer\| PubMed ID: 33023982	2020
Prospective evaluation of the prognostic value of immune-related adverse events in patients with non-melanoma solid tumour treated with PD-1/PD-L1 inhibitors alone and in combination with ra... European journal of cancer (Oxford, England : 1990)\| PubMed ID: 33045663	2020
Prospective Evaluation of All-lesion Versus Single-lesion Radiotherapy in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors. Frontiers in oncology\| PubMed ID: 33251140	2020
Radon Exposure-Therapeutic Effect and Cancer Risk. International journal of molecular sciences\| PubMed ID: 33396815	2020
Gas plasma irradiation of breast cancers promotes immunogenicity, tumor reduction, and an abscopal effect in vivo. Oncoimmunology\| PubMed ID: 33457077	2020
Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment. Cancers\| PubMed ID: 33572437	2021
Prospective development and validation of a liquid immune profile-based signature (LIPS) to predict response of patients with recurrent/metastatic cancer to immune checkpoint inhibitors. Journal for immunotherapy of cancer\| PubMed ID: 33593828	2021
Questionnaire-based detection of immune-related adverse events in cancer patients treated with PD-1/PD-L1 immune checkpoint inhibitors. BMC cancer\| PubMed ID: 33761922	2021
Radiotherapy and the immune system: More than just immune suppression. Stem cells (Dayton, Ohio)\| PubMed ID: 33961721	2021
In Vitro Examinations of Cell Death Induction and the Immune Phenotype of Cancer Cells Following Radiative-Based Hyperthermia with 915 MHz in Combination with Radiotherapy. Cells\| PubMed ID: 34201238	2021
Graphene-Induced Hyperthermia (GIHT) Combined With Radiotherapy Fosters Immunogenic Cell Death. Frontiers in oncology\| PubMed ID: 34485114	2021
Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only ... International journal of molecular sciences\| PubMed ID: 34502022	2021
Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 34665291	2022
Reduction of Elective Radiotherapy Treatment Volume in Definitive Treatment of Locally Advanced Head and Neck Cancer-Comparison of a Prospective Trial with a Revised Simulated Contouring App... Journal of clinical medicine\| PubMed ID: 34682782	2021
Low Dose Radiation Therapy Induces Long-Lasting Reduction of Pain and Immune Modulations in the Peripheral Blood - Interim Analysis of the IMMO-LDRT01 Trial. Frontiers in immunology\| PubMed ID: 34712229	2021
Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma. Frontiers in oncology\| PubMed ID: 34745957	2021
[Definitive chemoradiotherapy of locally advanced head and neck cancer in combination with immune checkpoint inhibition-new concepts required]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 34873636	2022
Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients. Frontiers in immunology\| PubMed ID: 35046940	2021
Induction chemoimmunotherapy followed by CD8+ immune cell-based patient selection for chemotherapy-free radioimmunotherapy in locally advanced head and neck cancer. Journal for immunotherapy of cancer\| PubMed ID: 35078923	2022
Corrigendum: Low Dose Radiation Therapy Induces Long-Lasting Reduction of Pain and Immune Modulations in the Peripheral Blood - Interim Analysis of the IMMO-LDRT01 Trial. Frontiers in immunology\| PubMed ID: 35197987	2022
Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration. Cells\| PubMed ID: 35203348	2022
[Highlights from the 2021 ASCO and ESMO annual meetings on radiotherapy of head and neck cancer]. HNO\| PubMed ID: 35294576	2022
The Effect of Hyperthermia and Radiotherapy Sequence on Cancer Cell Death and the Immune Phenotype of Breast Cancer Cells. Cancers\| PubMed ID: 35565180	2022
Detailed analyses of the impact of multimodal cancer therapy with hyperthermia and radiotherapy on the immune phenotype of human glioblastoma cells. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 35676615	2022
Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 36229655	2023
Newly Synthesized Melphalan Analogs Induce DNA Damage and Mitotic Catastrophe in Hematological Malignant Cancer Cells. International journal of molecular sciences\| PubMed ID: 36430734	2022
Normofractionated irradiation and not temozolomide modulates the immunogenic and oncogenic phenotype of human glioblastoma cell lines. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 36480032	2023
Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects-challenges for future studies. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 36602569	2023
Identification and characterization of circular RNAs as novel putative biomarkers to predict anti-PD-1 monotherapy response in metastatic melanoma patients - Knowledge from two independent i... Neoplasia (New York, N.Y.)\| PubMed ID: 36696838	2023
Prospective Evaluation of CD45RA+/CCR7- Effector Memory T (T) Cell Subsets in Patients with Primary and Secondary Brain Tumors during Radiotherapy of the Brain within the Scope of the Prospe... Cells\| PubMed ID: 36831183	2023
Deep learning for automatic head and neck lymph node level delineation provides expert-level accuracy. Frontiers in oncology\| PubMed ID: 36874135	2023
The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview. International review of cell and molecular biology\| PubMed ID: 36997271	2023
[No abscopal effects of immunotherapy combined with stereotactic radiation therapy in Merkel cell carcinoma]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 37042974	2023
Editorial: Systemic immune dysregulation in malignant disease: Insights, monitoring and therapeutic exploitation. Frontiers in oncology\| PubMed ID: 37077834	2023
Clonogenicity-based radioresistance determines the expression of immune suppressive immune checkpoint molecules after hypofractionated irradiation of MDA-MB-231 triple-negative breast cancer... Frontiers in oncology\| PubMed ID: 37152024	2023
Identification of an endogenous retroviral signature to predict anti-PD1 response in advanced clear cell renal cell carcinoma: an integrated analysis of three clinical trials. Therapeutic advances in medical oncology\| PubMed ID: 37614979	2022
Deep Learning and Registration-Based Mapping for Analyzing the Distribution of Nodal Metastases in Head and Neck Cancer Cohorts: Informing Optimal Radiotherapy Target Volume Design. Cancers\| PubMed ID: 37760588	2023
Broadband microwave spiral applicator (105-125 MHz) for examinations of hyperthermia-induced tumor cell death forms - first analyses with human breast cancer cells. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 37813393	2023
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor c... Neoplasia (New York, N.Y.)\| PubMed ID: 37857049	2023
Immune modulation during anti-cancer radio(immuno)therapy. International review of cell and molecular biology\| PubMed ID: 38225105	2024
Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell c... Neoplasia (New York, N.Y.)\| PubMed ID: 38232493	2024
Osteo-immunological impact of radon spa treatment: due to radon or spa alone? Results from the prospective, thermal bath placebo-controlled RAD-ON02 trial. Frontiers in immunology\| PubMed ID: 38292488	2023
Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders- results from a prospective, randomized, placebo-controlled tria... Frontiers in immunology\| PubMed ID: 38380316	2024
Effect of micro- and nanoplastic particles on human macrophages. Journal of hazardous materials\| PubMed ID: 38642497	2024
Do Not Forget the Granulocytic Compartment's Role in T cell-Mediated Antitumor Immunity. Cancer immunology research\| PubMed ID: 38952273	2024
Comprehensive multimodal deep learning survival prediction enabled by a transformer architecture: A multicenter study in glioblastoma. Neuro-oncology advances\| PubMed ID: 39156618	2024
Defining intra-tumoral and systemic immune biomarkers for locally advanced head-and-neck cancer - detailed protocol of a prospective, observatory multicenter trial (ImmunBioKHT) and first re... Frontiers in oncology\| PubMed ID: 39346733	2024
Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC. Frontiers in oncology\| PubMed ID: 39411143	2024
The Segment Anything foundation model achieves favorable brain tumor auto-segmentation accuracy in MRI to support radiotherapy treatment planning. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]\| PubMed ID: 39503868	2025
Efficacy of radiotherapy combined with atezolizumab or docetaxel in patients with previously treated NSCLC. iScience\| PubMed ID: 39640586	2024
Single-cell RNA-seq reveals as a prognostic biomarker in low-grade endometrial stromal sarcoma. Frontiers in immunology\| PubMed ID: 39676856	2024
Flow cytometry-based monitoring of myeloid-derived suppressor cells in the peripheral blood of patients with solid tumors. Methods in cell biology\| PubMed ID: 39824553	2025