Intan Safinar Ismail

Laboratory of Natural Products, Universiti Putra Malaysia

Affiliated withUniversiti Putra Malaysia

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Rapid Quantification and Validation of Biomarker Scopoletin in by qNMR and UV-Vis for Herbal Preparation. Molecules (Basel, Switzerland)\| PubMed ID: 33171900	2020
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. Bioorganic & medicinal chemistry\| PubMed ID: 21958738	2011
(20S,24S)-25-Hy-droxy-20,24-ep-oxy-A-homo-4-oxadammaran-3-one (Chrysura) isolated from the leaves of Walsura chrysogyne. Acta crystallographica. Section E, Structure reports online\| PubMed ID: 22199798	2011
Steroids from Dysoxylum grande (Meliaceae) leaves. Steroids\| PubMed ID: 23178158	2013
Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest. Journal of ethnopharmacology\| PubMed ID: 23353897	2013
Chrotacumines E and F, two new chromone-alkaloid analogs from Dysoxylum acutangulum (Meliaceae) leaves. Chemistry & biodiversity\| PubMed ID: 24078592	2013
Dillenia Suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules (Basel, Switzerland)\| PubMed ID: 24172241	2013
Chrotacumines G-J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 24767841	2014
Effect of Defatted Dabai Pulp Extract in Urine Metabolomics of Hypercholesterolemic Rats. Nutrients\| PubMed ID: 33202660	2020
Chemical profile and antiacetylcholinesterase, antityrosinase, antioxidant and α-glucosidase inhibitory activity of Cynometra cauliflora L. leaves. Journal of the science of food and agriculture\| PubMed ID: 25048579	2015
Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor. Molecules (Basel, Switzerland)\| PubMed ID: 25100256	2014
Infrared-metabolomics approach in detecting changes in Andrographis paniculata metabolites due to different harvesting ages and times. Journal of the science of food and agriculture\| PubMed ID: 25371390	2015
Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root. BMC complementary and alternative medicine\| PubMed ID: 25652309	2015
Competing role of bioactive constituents in Moringa oleifera extract and conventional nutrition feed on the performance of Cobb 500 broilers. BioMed research international\| PubMed ID: 25793214	2015
Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway. Journal of ethnopharmacology\| PubMed ID: 25797115	2015
Relationship Between Metabolites Composition and Biological Activities of Phyllanthus niruri Extracts Prepared by Different Drying Methods and Solvents Extraction. Plant foods for human nutrition (Dordrecht, Netherlands)\| PubMed ID: 25800644	2015
Phytochemicals from Mangifera pajang Kosterm and their biological activities. BMC complementary and alternative medicine\| PubMed ID: 25887035	2015
Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemic... PloS one\| PubMed ID: 26047480	2015
Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts. BioMed research international\| PubMed ID: 26819955	2015
Molecular Docking Analysis of Selected Clinacanthus nutans Constituents as Xanthine Oxidase, Nitric Oxide Synthase, Human Neutrophil Elastase, Matrix Metalloproteinase 2, Matrix Metalloprote... Pharmacognosy magazine\| PubMed ID: 27041853	2016
Bioactive Constituents of Zanthoxylum rhetsa Bark and Its Cytotoxic Potential against B16-F10 Melanoma Cancer and Normal Human Dermal Fibroblast (HDF) Cell Lines. Molecules (Basel, Switzerland)\| PubMed ID: 27231889	2016
Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 27318080	2016
Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats. Molecules (Basel, Switzerland)\| PubMed ID: 27517894	2016
Discrimination and Nitric Oxide Inhibitory Activity Correlation of Ajwa Dates from Different Grades and Origin. Molecules (Basel, Switzerland)\| PubMed ID: 27801841	2016
Urinary metabolic profiling of cisplatin nephrotoxicity and nephroprotective effects of Orthosiphon stamineus leaves elucidated by H NMR spectroscopy. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 27987392	2017
Identification of the compositional changes in Orthosiphon stamineus leaves triggered by different drying techniques using H NMR metabolomics. Journal of the science of food and agriculture\| PubMed ID: 28233369	2017
Stability Study of Algerian Seeds Stored under Different Conditions. Journal of analytical methods in chemistry\| PubMed ID: 28255502	2017
A new pyranoxanthone from Garcinia nervosa. Natural product research\| PubMed ID: 28412841	2017
Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via H NMR spectroscopy. BMC complementary and alternative medicine\| PubMed ID: 28545435	2017
Structural characterization and evaluation of prebiotic activity of oil palm kernel cake mannanoligosaccharides. Food chemistry\| PubMed ID: 28551246	2017
Characterization of Metabolite Profile in Phyllanthus niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics. Molecules (Basel, Switzerland)\| PubMed ID: 28556789	2017
Comparison of partial least squares and random forests for evaluating relationship between phenolics and bioactivities of Neptunia oleracea. Journal of the science of food and agriculture\| PubMed ID: 28580581	2018
Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities. Natural product research\| PubMed ID: 28715912	2018
Discriminative Analysis of Different Grades of Gaharu (Aquilaria malaccensis Lamk.) via ¹H-NMR-Based Metabolomics Using PLS-DA and Random Forests Classification Models. Molecules (Basel, Switzerland)\| PubMed ID: 28946701	2017
A new coumarin from stem bark of Calophyllum wallichianum. Natural product research\| PubMed ID: 29355031	2018
Metabolite characterization of different palm date varieties and the correlation with their NO inhibitory activity, texture and sweetness. Journal of food science and technology\| PubMed ID: 29606769	2018
Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin. Phytotherapy research : PTR\| PubMed ID: 29672974	2018
Metabolite Profiling of the Microalgal Diatom and Correlation with Antioxidant and Nitric Oxide Inhibitory Activities via ¹H NMR-Based Metabolomics. Marine drugs\| PubMed ID: 29735927	2018
Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal- and obese-diabetic rats. Journal of physiology and biochemistry\| PubMed ID: 29766441	2018
Solvent Extraction and Identification of Active Anticariogenic Metabolites in L. through ¹H-NMR-Based Metabolomics Approach. Molecules (Basel, Switzerland)\| PubMed ID: 30012946	2018
Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR- and LC-MS-Based Metabolomics Approach. Molecules (Basel, Switzerland)\| PubMed ID: 30154302	2018
Hits-to-Lead Optimization of the Natural Compound 2,4,6-Trihydroxy-3-geranyl-acetophenone (tHGA) as a Potent LOX Inhibitor: Synthesis, Structure-Activity Relationship (SAR) Study, and Comput... Molecules (Basel, Switzerland)\| PubMed ID: 30274341	2018
Antioxidants and α-glucosidase inhibitors from Neptunia oleracea fractions using H NMR-based metabolomics approach and UHPLC-MS/MS analysis. BMC complementary and alternative medicine\| PubMed ID: 30616569	2019
NMR metabolomics for evaluating passage number and harvesting effects on mammalian cell metabolome. Analytical biochemistry\| PubMed ID: 30970239	2019
Effects of leaf extract on lipopolysaccharide -induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study. Avicenna journal of phytomedicine\| PubMed ID: 30984581	2019
Extraction and Characterization of Organ Components of the Malaysian Sea Cucumber Yielded Bioactives Exhibiting Diverse Properties. BioMed research international\| PubMed ID: 31119160	2019
Comparative study of the antidiabetic potential of twig extracts and compounds from two different locations in Malaysia. Pharmaceutical biology\| PubMed ID: 31185767	2019
Phytochemical and anti-inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR-based metabolomics. Phytochemical analysis : PCA\| PubMed ID: 31243835	2020
Identification of Antidiabetic Metabolites from L. Twigs by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Study. BioMed research international\| PubMed ID: 31275982	2019
Verification and evaluation of monochloropropanediol (MCPD) esters and glycidyl esters in palm oil products of different regions in Malaysia. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment\| PubMed ID: 31437078	2019
Cytotoxic xanthones isolated from Calophyllum depressinervosum and Calophyllum buxifolium with antioxidant and cytotoxic activities. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 31479710	2019
H-NMR-based metabolomics to investigate the effects of Phoenix dactylifera seed extracts in LPS-IFN-γ-induced RAW 264.7 cells. Food research international (Ottawa, Ont.)\| PubMed ID: 31554083	2019
Acetylcholinesterase and α-glucosidase inhibitory compounds from . Natural product research\| PubMed ID: 31631709	2021
UHPLC-ESI-Orbitrap-MS Analysis of Biologically Active Extracts from (Lour.) Merr. and L. Leaves. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 32047522	2020
H NMR-Based Metabolomics Approach in Investigating the Chemical Profile, Antioxidant and Anti-Inflammatory Activities of Gynura procumbens and Cleome gynandra. Plant foods for human nutrition (Dordrecht, Netherlands)\| PubMed ID: 32152783	2020
Antioxidant, α-Glucosidase, and Nitric Oxide Inhibitory Activities of Six Algerian Traditional Medicinal Plant Extracts and H-NMR-Based Metabolomics Study of the Active Extract. Molecules (Basel, Switzerland)\| PubMed ID: 32164186	2020
Potency of Selected Berries, Grapes, and Citrus Fruit as Neuroprotective Agents. Evidence-based complementary and alternative medicine : eCAM\| PubMed ID: 32565853	2020
Metabolite Profiles of Red and Yellow Watermelon () Cultivars Using a H-NMR Metabolomics Approach. Molecules (Basel, Switzerland)\| PubMed ID: 32679913	2020
Comprehensive GCMS and LC-MS/MS Metabolite Profiling of . Marine drugs\| PubMed ID: 32709006	2020
Mass Spectrometry-Based Metabolomics Combined with Quantitative Analysis of the Microalgal Diatom (). Marine drugs\| PubMed ID: 32751412	2020
Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study. Nutrients\| PubMed ID: 32872655	2020
The anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray. PloS one\| PubMed ID: 32925968	2020
Urine Untargeted Metabolomic Profiling Is Associated with the Dietary Pattern of Successful Aging among Malaysian Elderly. Nutrients\| PubMed ID: 32977370	2020
NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition. BMC complementary medicine and therapies\| PubMed ID: 33092571	2020
Anti-inflammatory evaluation of Scurrula ferruginea (jack) danser parasitizing on Tecoma stans (L.) H.B.K. in LPS/IFN-γ-induced RAW 264.7 macrophages. Journal of ethnopharmacology\| PubMed ID: 33271242	2021
Potential of Using Ginger Essential Oils-Based Nanotechnology to Control Tropical Plant Diseases. The plant pathology journal\| PubMed ID: 33312089	2020
Serum Metabolomics Profiling of Commercially Mixed Functional Foods-Effects in Beta-Amyloid Induced Rats Measured Using H NMR Spectroscopy. Nutrients\| PubMed ID: 33322743	2020
Quality of Dabai Pulp Oil Extracted by Supercritical Carbon Dioxide and Supplementation in Hypercholesterolemic Rat-A New Alternative Fat. Foods (Basel, Switzerland)\| PubMed ID: 33513823	2021
Hepatoprotective Effect of Supercritical Carbon Dioxide Extracted Dabai Pulp Oil and Its Defatted Pulp. Molecules (Basel, Switzerland)\| PubMed ID: 33525363	2021
Perturbations in Amino Acid Metabolism in Reserpine-Treated Zebrafish Brain Detected by H Nuclear Magnetic Resonance-Based Metabolomics. Zebrafish\| PubMed ID: 33538644	2021
H NMR-based metabolomics and UHPLC-ESI-MS/MS for the investigation of bioactive compounds from Lupinus albus fractions. Food research international (Ottawa, Ont.)\| PubMed ID: 33648271	2021
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug. Scientific reports\| PubMed ID: 33727582	2021
Complementary Analytical Platforms of NMR Spectroscopy and LCMS Analysis in the Metabolite Profiling of . Marine drugs\| PubMed ID: 33801258	2021
Rapid characterisation of xanthine oxidase inhibitors from the flowers of Chrysanthemum morifolium Ramat. Using metabolomics approach. Phytochemical analysis : PCA\| PubMed ID: 34000756	2022
Multi-Platform Metabolomics Analyses Revealed the Complexity of Serum Metabolites in LPS-Induced Neuroinflammed Rats Treated with Aqueous Extract. Frontiers in pharmacology\| PubMed ID: 34177565	2021
Ginger Essential Oils-Loaded Nanoemulsions: Potential Strategy to Manage Bacterial Leaf Blight Disease and Enhanced Rice Yield. Molecules (Basel, Switzerland)\| PubMed ID: 34202405	2021
Clitorienolactones and Isoflavonoids of Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model. Molecules (Basel, Switzerland)\| PubMed ID: 34299411	2021
Investigation of Andrographolide Effect on Non-Infected Red Blood Cells Using the H-NMR-Based Metabolomics Approach. Metabolites\| PubMed ID: 34436427	2021
An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 34563950	2021
Preliminary Evaluation of Supercritical Carbon Dioxide Extracted Dabai Pulp Oleoresin as a New Alternative Fat. Molecules (Basel, Switzerland)\| PubMed ID: 34577016	2021
Rebaudioside A Enhances LDL Cholesterol Uptake in HepG2 Cells via Suppression of Expression. Reports of biochemistry & molecular biology\| PubMed ID: 34981026	2021
Metabolomic Approach for Rapid Identification of Antioxidants in Leaves with Liver Protective Potential. Molecules (Basel, Switzerland)\| PubMed ID: 35744776	2022
Synthesis of benzylated amine-substituted xanthone derivatives and their antioxidant and anti-inflammatory activities. Archiv der Pharmazie\| PubMed ID: 36285691	2023
Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via H Nuclear Magnetic Resonance (NMR)-based met... Comparative biochemistry and physiology. Toxicology & pharmacology : CBP\| PubMed ID: 36336330	2023
Immunomodulatory effects of Isochrysis galbana incorporated diet on Oreochromis sp. (red hybrid tilapia) via Sera-H NMR metabolomics study. Fish & shellfish immunology\| PubMed ID: 36464078	2023
Indonesian Mangrove Leaves Ethanol Extract Is a Potential Super Antioxidant and Anti Methicillin-Resistant Drug. Molecules (Basel, Switzerland)\| PubMed ID: 36500458	2022
A Study of the Interaction between Xanthine Oxidase and Its Inhibitors from Using Computational Simulation and Multispectroscopic Methods. Metabolites\| PubMed ID: 36677038	2023
Study on the acute toxicity of sodium taurocholate via zebrafish mortality, behavioral response, and NMR-metabolomics analysis. Drug and chemical toxicology\| PubMed ID: 37548163	2024
Protective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity on human kidney cell (PCS-400-010) elucidated by an LCMS-based metabolomics approach. Biomedical chromatography : BMC\| PubMed ID: 37778127	2023
Dietary supplementation of improves the immunity of Asian seabass, (Bloch, 1790) against infection. Fish and shellfish immunology reports\| PubMed ID: 37822351	2023
Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio-resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂. Journal of fish diseases\| PubMed ID: 38523352	2024
Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers. Expert reviews in molecular medicine\| PubMed ID: 38606593	2024
H NMR-metabolomics studies on acute toxicity effect of lead in adult zebrafish () model. Drug and chemical toxicology\| PubMed ID: 38726945	2024
Combined knee osteoarthritis and diabetes is associated with reduced muscle strength, physical inactivity, and poorer quality of life. Journal of rehabilitation medicine\| PubMed ID: 39225040	2024