W. Todd Miller

Department of Physiology and Biophysics, Stony Brook University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Substrate recognition by the human fatty-acid synthase. The Journal of biological chemistry\| PubMed ID: 16215233	2005
Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase. The Journal of biological chemistry\| PubMed ID: 16257963	2005
Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. The Journal of biological chemistry\| PubMed ID: 16707485	2006
Receptor tyrosine kinases: mechanisms of activation and signaling. Current opinion in cell biology\| PubMed ID: 17306972	2007
Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region. FEBS letters\| PubMed ID: 17586502	2007
Processive phosphorylation: mechanism and biological importance. Cellular signalling\| PubMed ID: 17644338	2007
Cooperative activation of Src family kinases by SH3 and SH2 ligands. Cancer letters\| PubMed ID: 17719722	2007
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature\| PubMed ID: 18273011	2008
Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation. The Journal of biological chemistry\| PubMed ID: 18390552	2008
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. The EMBO journal\| PubMed ID: 18566589	2008
The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18621719	2008
The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition. Biochemistry\| PubMed ID: 18803405	2008
A crystallographic snapshot of tyrosine trans-phosphorylation in action. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19060208	2008
Evidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinase. Biochemistry\| PubMed ID: 19413338	2009
Reengineering the signaling properties of a Src family kinase. Biochemistry\| PubMed ID: 19827767	2009
Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1. The Journal of biological chemistry\| PubMed ID: 20110370	2010
Regulation of Ack1 localization and activity by the amino-terminal SAM domain. BMC biochemistry\| PubMed ID: 20979614	2010
PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis. PloS one\| PubMed ID: 21541291	2011
Regulation of ack-family nonreceptor tyrosine kinases. Journal of signal transduction\| PubMed ID: 21637378	2011
Tyrosine kinase signaling and the emergence of multicellularity. Biochimica et biophysica acta\| PubMed ID: 22480439	2012
Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling. Journal of signal transduction\| PubMed ID: 22778948	2012
Lack of Csk-mediated negative regulation in a unicellular SRC kinase. Biochemistry\| PubMed ID: 22998693	2012
SRC points the way to biomarkers and chemotherapeutic targets. Genes & cancer\| PubMed ID: 23226580	2012
Metazoan-like signaling in a unicellular receptor tyrosine kinase. BMC biochemistry\| PubMed ID: 23398683	2013
Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. The Journal of biological chemistry\| PubMed ID: 23530051	2013
Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans. Biochemistry\| PubMed ID: 24520931	2014
Closing in on a mechanism for activation. eLife\| PubMed ID: 25350976	2014
The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. Nature communications\| PubMed ID: 25758790	2015
Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase. The Journal of biological chemistry\| PubMed ID: 25897081	2015
Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition. Biochemistry\| PubMed ID: 25940761	2015
PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility. Experimental cell research\| PubMed ID: 25959509	2015
Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase. PloS one\| PubMed ID: 26090675	2015
Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids. Biochemistry\| PubMed ID: 26271001	2015
Auto-thiophosphorylation activity of Src tyrosine kinase. BMC biochemistry\| PubMed ID: 27387461	2016
Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell chemical biology\| PubMed ID: 27593110	2016
Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells. Analytical biochemistry\| PubMed ID: 28830678	2017
Src signaling in a low-complexity unicellular kinome. Scientific reports\| PubMed ID: 29599515	2018
Identification of a Water-Coordinating HER2 Inhibitor by Virtual Screening Using Similarity-Based Scoring. Biochemistry\| PubMed ID: 29975516	2018
Src and podoplanin forge a path to destruction. Drug discovery today\| PubMed ID: 30077780	2019
What Makes a Kinase Promiscuous for Inhibitors? Cell chemical biology\| PubMed ID: 30612951	2019
Sterol structure dependence of insulin receptor and insulin-like growth factor 1 receptor activation. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 30682326	2019
Substrate binding to Src: A new perspective on tyrosine kinase substrate recognition from NMR and molecular dynamics. Protein science : a publication of the Protein Society\| PubMed ID: 31697410	2020
Structure, Function, and Regulation of the SRMS Tyrosine Kinase. International journal of molecular sciences\| PubMed ID: 32545875	2020
Temperature sensitivities of metazoan and pre-metazoan Src kinases. Biochemistry and biophysics reports\| PubMed ID: 32566764	2020
Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 33904620	2021
Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered raft domains. The Journal of biological chemistry\| PubMed ID: 34324831	2021
Inhibition of mutationally activated HER2. Chemical biology & drug design\| PubMed ID: 36029027	2023
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region. FEBS letters\| PubMed ID: 36178070	2022
The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity. The Journal of biological chemistry\| PubMed ID: 36334623	2022
Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nature communications\| PubMed ID: 36376335	2022
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry\| PubMed ID: 36854171	2023
Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Cells\| PubMed ID: 36980241	2023
Colorectal cancer-associated mutations impair EphB1 kinase function. The Journal of biological chemistry\| PubMed ID: 37527777	2023
Phosphorylation of Ack1 by the Receptor Tyrosine Kinase Mer. Kinases and phosphatases\| PubMed ID: 37662484	2023
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine\| PubMed ID: 38061240	2024
Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 38071609	2024
Contrasting Effects of Cancer-Associated Mutations in EphA3 and EphB2 Kinases. Biochemistry\| PubMed ID: 38252844	2024
A microglia clonal inflammatory disorder in Alzheimer's Disease. bioRxiv : the preprint server for biology\| PubMed ID: 38328106	2024
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis. medRxiv : the preprint server for health sciences\| PubMed ID: 38883731	2024
Effects of heterologous kinase domains on growth factor receptor specificity. Cellular signalling\| PubMed ID: 39048037	2024
Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants. The FEBS journal\| PubMed ID: 39428852	2024
Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 39548957	2024
ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis. eLife\| PubMed ID: 39570652	2024
A microglia clonal inflammatory disorder in Alzheimer's disease. eLife\| PubMed ID: 40085681	2025