Kevin Kit Parker

Disease Biophysics Group, Harvard University

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2025

Other Publications

Article	Year
Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes. Biophysical journal\| PubMed ID: 17369419	2007
Muscular thin films for building actuators and powering devices. Science (New York, N.Y.)\| PubMed ID: 17823347	2007
Dynamic control of protein-protein interactions. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18052217	2008
Sarcomere alignment is regulated by myocyte shape. Cell motility and the cytoskeleton\| PubMed ID: 18561184	2008
Myofibrillar architecture in engineered cardiac myocytes. Circulation research\| PubMed ID: 18635822	2008
Control of myocyte remodeling in vitro with engineered substrates. In vitro cellular & developmental biology. Animal\| PubMed ID: 19252956	2009
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (New York, N.Y.)\| PubMed ID: 19833966	2009
Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circulation. Cardiovascular genetics\| PubMed ID: 20031575	2009
Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials\| PubMed ID: 20149449	2010
Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials\| PubMed ID: 20382423	2010
Surface-initiated assembly of protein nanofabrics. Nano letters\| PubMed ID: 20486679	2010
Nanofiber assembly by rotary jet-spinning. Nano letters\| PubMed ID: 20491499	2010
Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 21330361	2011
Self-organization of muscle cell structure and function. PLoS computational biology\| PubMed ID: 21390276	2011
Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Archiv : European journal of physiology\| PubMed ID: 21499986	2011
A possible role for integrin signaling in diffuse axonal injury. PloS one\| PubMed ID: 21799943	2011
Vascular smooth muscle contractility depends on cell shape. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21993765	2011
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab on a chip\| PubMed ID: 22072288	2011
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123981	2011
Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior. Journal of biomechanics\| PubMed ID: 22236531	2012
Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovascular research\| PubMed ID: 22287588	2012
Muscle on a chip: in vitro contractility assays for smooth and striated muscle. Journal of pharmacological and toxicological methods\| PubMed ID: 22521339	2012
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials\| PubMed ID: 22594976	2012
Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22675119	2012
The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomechanics and modeling in mechanobiology\| PubMed ID: 22772714	2012
A potential role for integrin signaling in mechanoelectrical feedback. Progress in biophysics and molecular biology\| PubMed ID: 22819851	2012
A tissue-engineered jellyfish with biomimetic propulsion. Nature biotechnology\| PubMed ID: 22820316	2012
Design standards for engineered tissues. Biotechnology advances\| PubMed ID: 23267860	2013
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23716679	2013
Microfluidic heart on a chip for higher throughput pharmacological studies. Lab on a chip\| PubMed ID: 23807141	2013
Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes. Stem cell reports\| PubMed ID: 24286027	2013
The contractile strength of vascular smooth muscle myocytes is shape dependent. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 24406783	2014
Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning. Biomaterials\| PubMed ID: 24456606	2014
The structure-function relationships of a natural nanoscale photonic device in cuttlefish chromatophores. Journal of the Royal Society, Interface\| PubMed ID: 24478280	2014
Three-dimensional paper-based model for cardiac ischemia. Advanced healthcare materials\| PubMed ID: 24574054	2014
Quality metrics for stem cell-derived cardiac myocytes. Stem cell reports\| PubMed ID: 24672752	2014
Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 24682394	2014
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials\| PubMed ID: 24731714	2014
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature medicine\| PubMed ID: 24813252	2014
Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab on a chip\| PubMed ID: 25093641	2014
The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 25125187	2014
Effect of solvent evaporation on fiber morphology in rotary jet spinning. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25353398	2014
Structural phenotyping of stem cell-derived cardiomyocytes. Stem cell reports\| PubMed ID: 25733020	2015
Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction. Neuron\| PubMed ID: 25789754	2015
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury. Scientific reports\| PubMed ID: 25820512	2015
Metrics for assessing cytoskeletal orientational correlations and consistency. PLoS computational biology\| PubMed ID: 25849553	2015
Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 25908635	2015
Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. Advanced functional materials\| PubMed ID: 26213529	2013
Extracellular matrix protein expression is brain region dependent. The Journal of comparative neurology\| PubMed ID: 26780384	2016
Angiotensin II Induced Cardiac Dysfunction on a Chip. PloS one\| PubMed ID: 26808388	2016
Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. The Journal of cell biology\| PubMed ID: 26858266	2016
Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduces contractility in vitro. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 27174867	2016
Microenvironmental Control of Adipocyte Fate and Function. Trends in cell biology\| PubMed ID: 27268909	2016
Phototactic guidance of a tissue-engineered soft-robotic ray. Science (New York, N.Y.)\| PubMed ID: 27387948	2016
A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility. The Journal of cell biology\| PubMed ID: 27697929	2016
Organ Chips: Quality Assurance Systems in Regenerative Medicine. Clinical pharmacology and therapeutics\| PubMed ID: 27709615	2017
Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip. Journal of neurophysiology\| PubMed ID: 28031399	2017
Mechanotransduction and Metabolism in Cardiomyocyte Microdomains. BioMed research international\| PubMed ID: 28044126	2016
Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarctio... Biomaterials\| PubMed ID: 28107664	2017
JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement. Biomaterials\| PubMed ID: 28445803	2017
Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities. Lab on a chip\| PubMed ID: 28608907	2017
Fabrication of Millimeter-Long Carbon Tubular Nanostructures Using the Self-Rolling Process Inherent in Elastic Protein Layers. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 28627043	2017
Comparative analysis of poly-glycolic acid-based hybrid polymer starter matrices for in vitro tissue engineering. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 28697435	2017
Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions. Journal of biomechanical engineering\| PubMed ID: 28857113	2017
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications. Biofabrication\| PubMed ID: 29337695	2018
Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing. Advanced healthcare materials\| PubMed ID: 29359866	2018
Formation of Multi-Component Extracellular Matrix Protein Fibers. Scientific reports\| PubMed ID: 29382927	2018
Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model. Biomaterials\| PubMed ID: 29549768	2018
Traction force microscopy of engineered cardiac tissues. PloS one\| PubMed ID: 29590169	2018
Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials. Analytical and bioanalytical chemistry\| PubMed ID: 29744562	2018
Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system. Nature biotechnology\| PubMed ID: 29806849	2018
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nature biotechnology\| PubMed ID: 30125269	2018
Scatter Enhanced Phase Contrast Microscopy for Discriminating Mechanisms of Active Nanoparticle Transport in Living Cells. Nano letters\| PubMed ID: 30616354	2019
Designer Assays for Your Sick, Subdivided Heart. Cell\| PubMed ID: 30735631	2019
A tissue-engineered scale model of the heart ventricle. Nature biomedical engineering\| PubMed ID: 31015723	2018
Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Circulation\| PubMed ID: 31311300	2019
Alfalfa Nanofibers for Dermal Wound Healing. ACS applied materials & interfaces\| PubMed ID: 31369233	2019
Inkjet-Printed Carbon Nanotubes for Fabricating a Spoof Fingerprint on Paper. ACS omega\| PubMed ID: 31459951	2019
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing. Lab on a chip\| PubMed ID: 31464325	2019
Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model. Nanoscale\| PubMed ID: 31553035	2019
Muscle tissue engineering in fibrous gelatin: implications for meat analogs. NPJ science of food\| PubMed ID: 31646181	2019
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation\| PubMed ID: 31707831	2020
Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair. ACS applied materials & interfaces\| PubMed ID: 31755704	2019
Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 32195539	2020
Laminar ventricular myocardium on a microelectrode array-based chip. Journal of materials chemistry. B\| PubMed ID: 32263387	2016
Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β. Biomaterials\| PubMed ID: 32521331	2020
Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. ACS biomaterials science & engineering\| PubMed ID: 32685675	2020
Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine. Advanced biosystems\| PubMed ID: 32744807	2020
A bioinspired and hierarchically structured shape-memory material. Nature materials\| PubMed ID: 32868876	2021
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes . Lab on a chip\| PubMed ID: 33034335	2020
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. Science translational medicine\| PubMed ID: 33055246	2020
Ultragentle manipulation of delicate structures using a soft robotic gripper. Science robotics\| PubMed ID: 33137785	2019
Mapping 2D- and 3D-distributions of metal/metal oxide nanoparticles within cleared human skin tissues. NanoImpact\| PubMed ID: 33251378	2020
Building Biomimetic Potency Tests for Islet Transplantation. Diabetes\| PubMed ID: 33472944	2021
Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34260377	2021
An autonomously swimming biohybrid fish designed with human cardiac biophysics. Science (New York, N.Y.)\| PubMed ID: 35143298	2022
Addendum: A tissue-engineered scale model of the heart ventricle. Nature biomedical engineering\| PubMed ID: 35260798	2022
Differential modulation of endothelial cytoplasmic protrusions after exposure to graphene-family nanomaterials. NanoImpact\| PubMed ID: 35560286	2022
Cellular and Engineered Organoids for Cardiovascular Models. Circulation research\| PubMed ID: 35679369	2022
Recreating the heart's helical structure-function relationship with focused rotary jet spinning. Science (New York, N.Y.)\| PubMed ID: 35857545	2022
Engineering multicellular living systems-a Keystone Symposia report. Annals of the New York Academy of Sciences\| PubMed ID: 36177947	2022
Biohybrid robots: recent progress, challenges, and perspectives. Bioinspiration & biomimetics\| PubMed ID: 36265472	2022
High-throughput coating with biodegradable antimicrobial pullulan fibres extends shelf life and reduces weight loss in an avocado model. Nature food\| PubMed ID: 37118042	2022
Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles. Nature materials\| PubMed ID: 37500957	2023
Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy. Stem cell reports\| PubMed ID: 37595583	2023
Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 37956903	2024
Self-organizing behaviors of cardiovascular cells on synthetic nanofiber scaffolds. APL bioengineering\| PubMed ID: 38046543	2023
Welcome to , a big tent for the biophysics community. Biophysics reviews\| PubMed ID: 38505630	2020
Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems. Nature communications\| PubMed ID: 39009604	2024
Bioinspired design of a tissue-engineered ray with machine learning. Science robotics\| PubMed ID: 39937888	2025