David Mendelowitz

Department of Pharmacology and Physiology, The George Washington University

Affiliated withThe George Washington University

Research Area

Biography

David Mendelowitz has not added Biography.
If you are David Mendelowitz and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons. Circulation research\| PubMed ID: 12907666	2003
Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15496661	2004
Prenatal nicotine exposure recruits an excitatory pathway to brainstem parasympathetic cardioinhibitory neurons during hypoxia/hypercapnia in the rat: implications for sudden infant death sy... Pediatric research\| PubMed ID: 16148074	2005
Differential control of central cardiorespiratory interactions by hypercapnia and the effect of prenatal nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16399669	2006
Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus. Journal of neurophysiology\| PubMed ID: 16914614	2006
5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus. Neuroscience\| PubMed ID: 17869437	2007
ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain research\| PubMed ID: 18295749	2008
5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuropharmacology\| PubMed ID: 18396300	2008
Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain research\| PubMed ID: 18590708	2008
The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome. Pediatric research\| PubMed ID: 19247214	2009
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia. Neuroscience\| PubMed ID: 19772899	2009
Respiratory modulation of premotor cardiac vagal neurons in the brainstem. Respiratory physiology & neurobiology\| PubMed ID: 20452467	2010
The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate. Journal of neurophysiology\| PubMed ID: 20484535	2010
Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain research\| PubMed ID: 20553874	2010
GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovascular research\| PubMed ID: 20736238	2011
α1-adrenergic receptors facilitate inhibitory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuroscience\| PubMed ID: 21771639	2011
5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia. Respiratory physiology & neurobiology\| PubMed ID: 21930251	2011
Anaesthetics differentially modulate the trigeminocardiac reflex excitatory synaptic pathway in the brainstem. The Journal of physiology\| PubMed ID: 21930602	2011
Orexinergic modulation of GABAergic neurotransmission to cardiac vagal neurons in the brain stem nucleus ambiguus changes during development. Neuroscience\| PubMed ID: 22390944	2012
β adrenergic receptor modulation of neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuroscience\| PubMed ID: 22425752	2012
Synaptic and intrinsic activation of GABAergic neurons in the cardiorespiratory brainstem network. PloS one\| PubMed ID: 22570717	2012
Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei. Journal of neuroscience methods\| PubMed ID: 22890236	2012
Modulation of bulbospinal rostral ventral lateral medulla neurons by hypoxia/hypercapnia but not medullary respiratory activity. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 23108653	2012
Perinatal sulfur dioxide exposure alters brainstem parasympathetic control of heart rate. Cardiovascular research\| PubMed ID: 23504550	2013
Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem. Journal of neurophysiology\| PubMed ID: 23657280	2013
Prenatal nicotine exposure enhances the trigeminocardiac reflex via serotonin receptor facilitation in brainstem pathways. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23766497	2013
Postnatal sulfur dioxide exposure reversibly alters parasympathetic regulation of heart rate. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 23774227	2013
Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability. Journal of neurochemistry\| PubMed ID: 24475741	2014
Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem α1 and β1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24790189	2014
Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons. The Journal of physiology\| PubMed ID: 24835174	2014
Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain research\| PubMed ID: 24933328	2014
Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 24958501	2014
Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea. Progress in brain research\| PubMed ID: 25194192	2014
Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons. PloS one\| PubMed ID: 25379676	2014
Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function. Cardiovascular research\| PubMed ID: 25514932	2015
Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 26371169	2015
Hard to swallow: Developmental biological insights into pediatric dysphagia. Developmental biology\| PubMed ID: 26554723	2016
Parasympathetic Vagal Control of Cardiac Function. Current hypertension reports\| PubMed ID: 26849575	2016
Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27016581	2016
Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats. Journal of neurophysiology\| PubMed ID: 27559138	2016
Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons. Neuroscience\| PubMed ID: 27693474	2016
How Does Angiotensin Activate Hypothalamic Neurons Essential for Controlling Sympathetic Activity and Blood Pressure? Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 27698058	2016
Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 28159808	2017
Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Scientific reports\| PubMed ID: 28281681	2017
Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. Cardiovascular research\| PubMed ID: 28472396	2017
Altered neurobiological function of brainstem hypoglossal neurons in DiGeorge/22q11.2 Deletion Syndrome. Neuroscience\| PubMed ID: 28687307	2017
Benefits of oxytocin administration in obstructive sleep apnea. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 28798255	2017
Combined hypoxia and hypercapnia, but not hypoxia alone, suppresses neurotransmission from orexin to hypothalamic paraventricular spinally-projecting neurons in weanling rats. Brain research\| PubMed ID: 29162453	2018
Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice. Frontiers in neurology\| PubMed ID: 30487776	2018
Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts. Frontiers in physiology\| PubMed ID: 30745877	2019
GABA and glycine neurons from the ventral medullary region inhibit hypoglossal motoneurons. Sleep\| PubMed ID: 31832664	2020
Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion Syndrome. Frontiers in neurology\| PubMed ID: 32082240	2020
Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice. American journal of respiratory cell and molecular biology\| PubMed ID: 32603263	2020
Disrupted Coordination of Hypoglossal Motor Control in a Mouse Model of Pediatric Dysphagia in DiGeorge/22q11.2 Deletion Syndrome. eNeuro\| PubMed ID: 32855199	2020
Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo control... Sleep medicine\| PubMed ID: 32862007	2020
Optogenetic Control of Cardiac Autonomic Neurons in Transgenic Mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32865752	2021
Cholinergic stimulation improves electrophysiological rate adaptation during pressure overload-induced heart failure in rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 33006920	2020
Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart. JACC. Clinical electrophysiology\| PubMed ID: 33357580	2020
Refinement of axonal conduction and myelination in the mouse optic nerve indicate an extended period of postnatal developmental plasticity. Developmental neurobiology\| PubMed ID: 35403346	2022
Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 36794581	2023
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction. Basic research in cardiology\| PubMed ID: 37801130	2023
Sex differences in cardiac transcriptomic response to neonatal sleep apnea. Physiological reports\| PubMed ID: 38981849	2024