Budd Tucker

Institute for Vision Research, University of Iowa

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PloS one\| PubMed ID: 21559507	2011
Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21825139	2011
Stem cells in large animal models of retinal and neurological disease. Stem cells international\| PubMed ID: 22666270	2012
Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem cells translational medicine\| PubMed ID: 23283489	2013
Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease. Human molecular genetics\| PubMed ID: 23918662	2013
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. eLife\| PubMed ID: 23991284	2013
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue engineering. Part A\| PubMed ID: 24320879	2014
Loss of CD34 expression in aging human choriocapillaris endothelial cells. PloS one\| PubMed ID: 24466138	2014
Structural and biochemical analyses of choroidal thickness in human donor eyes. Investigative ophthalmology & visual science\| PubMed ID: 24519422	2014
Photoreceptor cells with profound structural deficits can support useful vision in mice. Investigative ophthalmology & visual science\| PubMed ID: 24569582	2014
Mechanical properties of murine and porcine ocular tissues in compression. Experimental eye research\| PubMed ID: 24613781	2014
Stem cells for investigation and treatment of inherited retinal disease. Human molecular genetics\| PubMed ID: 24647603	2014
Is age-related macular degeneration a microvascular disease? Advances in experimental medicine and biology\| PubMed ID: 24664709	2014
Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy. PloS one\| PubMed ID: 24671090
Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma. Journal of stem cell research & therapy\| PubMed ID: 24883232	2014
ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature\| PubMed ID: 25030174	2014
The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. The American journal of pathology\| PubMed ID: 25204844	2014
Induction of trabecular meshwork cells from induced pluripotent stem cells. Investigative ophthalmology & visual science\| PubMed ID: 25298418	2014
Gene therapy using stem cells. Cold Spring Harbor perspectives in medicine\| PubMed ID: 25395375	2014
Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq. Experimental eye research\| PubMed ID: 25446321	2014
Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases. Progress in retinal and eye research\| PubMed ID: 25448922	2015
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Progress in retinal and eye research\| PubMed ID: 25486088	2015
Stem cells as tools for studying the genetics of inherited retinal degenerations. Cold Spring Harbor perspectives in medicine\| PubMed ID: 25502747	2014
Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis. Science translational medicine\| PubMed ID: 26062849	2015
Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study. Scientific reports\| PubMed ID: 26138532	2015
Prevascularized silicon membranes for the enhancement of transport to implanted medical devices. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 26316050	2016
Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibil... Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 26364624	2015
Selective accumulation of the complement membrane attack complex in aging choriocapillaris. Experimental eye research\| PubMed ID: 26368849	2016
Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Human molecular genetics\| PubMed ID: 26494905	2016
North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13. Ophthalmology\| PubMed ID: 26507665	2016
Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration. The Journal of pathology\| PubMed ID: 26564985	2016
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease. Stem cells translational medicine\| PubMed ID: 26683869	2016
Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 26692377	2016
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 26720480	2015
Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels. Biomacromolecules\| PubMed ID: 27008004	2016
A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids. Current protocols in stem cell biology\| PubMed ID: 27171793	2016
Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27274060	2016
Monomeric C-reactive protein and inflammation in Age-related Macular Degeneration. The Journal of pathology\| PubMed ID: 27376713	2016
Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration. Human gene therapy\| PubMed ID: 27400765	2016
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness. Scientific reports\| PubMed ID: 27471043	2016
Two-photon polymerization for production of human iPSC-derived retinal cell grafts. Acta biomaterialia\| PubMed ID: 28351682	2017
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 28384726	2017
Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa. Stem cell research\| PubMed ID: 28390992	2017
Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium. Stem cells translational medicine\| PubMed ID: 28474838	2017
Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies. Acta biomaterialia\| PubMed ID: 28483697	2017
Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease. Ophthalmology\| PubMed ID: 28559085	2017
Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28619647	2017
Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy. Current protocols in stem cell biology\| PubMed ID: 28806854	2017
Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism. Ophthalmic genetics\| PubMed ID: 28949775	2018
Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants. Human gene therapy\| PubMed ID: 29160116	2018
CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 29512106	2018
CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration. Progress in retinal and eye research\| PubMed ID: 29578069	2018
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells. Biology open\| PubMed ID: 29685994	2018
Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors. Eye (London, England)\| PubMed ID: 30013157	2018
Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications. Biomacromolecules\| PubMed ID: 30044915	2018
Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury. Scientific reports\| PubMed ID: 30190604	2018
Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices. International journal of pharmaceutics\| PubMed ID: 30268853	2018
Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate. Macromolecular bioscience\| PubMed ID: 30430755	2019
Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig. Translational vision science & technology\| PubMed ID: 30519502	2018
Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter. Microvascular research\| PubMed ID: 30571950	2019
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30622176	2019
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. Cell reports\| PubMed ID: 30759402	2019
Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9. Genes\| PubMed ID: 30959774	2019
Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments. Stem cells translational medicine\| PubMed ID: 31004408	2019
Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis. Ophthalmology. Retina\| PubMed ID: 31014769	2019
CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in in Induced Pluripotent Stem Cells from Patients with Batten Disease. The CRISPR journal\| PubMed ID: 31021193	2018
Choriocapillaris Degeneration in Geographic Atrophy. The American journal of pathology\| PubMed ID: 31051169	2019
Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility. Acta biomaterialia\| PubMed ID: 31055121	2019
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of -Associated X-Linked Retinitis Pigmentosa. Human gene therapy\| PubMed ID: 31106594	2019
Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 31414943	2020
Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats. Human gene therapy\| PubMed ID: 31456426	2019
Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31712411	2019
AUTOIMMUNE RETINOPATHY MIMICKING HERITABLE RETINAL DEGENERATION IN A PATIENT WITH COMMON VARIABLE IMMUNE DEFICIENCY. Retinal cases & brief reports\| PubMed ID: 31764884	2022
Autologous cell replacement: a noninvasive AI approach to clinical release testing. The Journal of clinical investigation\| PubMed ID: 31961338	2020
Single-Cell RNA Sequencing in Human Retinal Degeneration Reveals Distinct Glial Cell Populations. Cells\| PubMed ID: 32069977	2020
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. Microvascular research\| PubMed ID: 32531351	2020
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy. American journal of human genetics\| PubMed ID: 32707085	2020
Label-free microfluidic enrichment of photoreceptor cells. Experimental eye research\| PubMed ID: 32771499	2020
Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis. Experimental eye research\| PubMed ID: 32910939	2020
Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats. Human gene therapy\| PubMed ID: 32948113	2020
Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells. Stem cell research & therapy\| PubMed ID: 32967716	2020
Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease. Progress in retinal and eye research\| PubMed ID: 33130253	2021
Predominance of hyperopia in autosomal dominant Best vitelliform macular dystrophy. The British journal of ophthalmology\| PubMed ID: 33243830	2022
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. Progress in retinal and eye research\| PubMed ID: 33383180	2021
A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative... Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 33440745	2021
The effect of retinal scaffold modulus on performance during surgical handling. Experimental eye research\| PubMed ID: 33838142	2021
Human photoreceptor cells from different macular subregions have distinct transcriptional profiles. Human molecular genetics\| PubMed ID: 34014299	2021
Microfluidic processing of stem cells for autologous cell replacement. Stem cells translational medicine\| PubMed ID: 34156760	2021
An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings. Journal of neuropathology and experimental neurology\| PubMed ID: 34313756	2021
Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease. Ophthalmology. Retina\| PubMed ID: 34416425	2022
Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites. Scientific reports\| PubMed ID: 34504124	2021
Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Gene therapy\| PubMed ID: 34518651	2022
Sensitive quantification of m.3243A>G mutational proportion in non-retinal tissues and its relationship with visual symptoms. Human molecular genetics\| PubMed ID: 34590675	2022
Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 34597181	2021
Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy. BMJ open ophthalmology\| PubMed ID: 34993349	2021
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration. The Journal of pathology\| PubMed ID: 35038170	2022
Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration. Human molecular genetics\| PubMed ID: 35181781	2022
Retinal Capillary Hemangioma Leading to a Diagnosis of von Hippel-Lindau Disease in a Patient with Retinopathy of Prematurity. Case reports in ophthalmology\| PubMed ID: 35702652	2022
Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats. Cell transplantation\| PubMed ID: 35758274	2022
The Essential Role of the Choriocapillaris in Vision: Novel Insights from Imaging and Molecular Biology. Annual review of vision science\| PubMed ID: 36108103	2022
Vascular Findings in the Choriocapillaris in a Case of Radiation Retinopathy Secondary to Choroidal Melanoma. Case reports in ophthalmology\| PubMed ID: 36160486	2022
Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy. Gene therapy\| PubMed ID: 36175490	2023
Transcriptomic and Chromatin Accessibility Analysis of the Human Macular and Peripheral Retinal Pigment Epithelium at the Single-Cell Level. The American journal of pathology\| PubMed ID: 36775060	2023
The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal. Human gene therapy\| PubMed ID: 36793189	2023
Automating iPSC generation to enable autologous photoreceptor cell replacement therapy. Journal of translational medicine\| PubMed ID: 36855199	2023
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report. Stem cell research & therapy\| PubMed ID: 36978104	2023
Photopolymerization Parameters Influence Mechanical, Microstructural, and Cell Loading Properties of Rapidly Fabricated Cell Scaffolds. ACS biomaterials science & engineering\| PubMed ID: 37075323	2023
Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement. Stem cells translational medicine\| PubMed ID: 37221451	2023
Multimodal single-cell analysis of nonrandom heteroplasmy distribution in human retinal mitochondrial disease. JCI insight\| PubMed ID: 37289546	2023
GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS. bioRxiv : the preprint server for biology\| PubMed ID: 37398429	2023
Automated human induced pluripotent stem cell colony segmentation for use in cell culture automation applications. SLAS technology\| PubMed ID: 37454765	2023
CGMP Compliant Microfluidic Transfection of Induced Pluripotent Stem Cells for CRISPR-Mediated Genome Editing. Stem cells (Dayton, Ohio)\| PubMed ID: 37632456	2023
Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics. Investigative ophthalmology & visual science\| PubMed ID: 37878301	2023
Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data. Human molecular genetics\| PubMed ID: 37930186	2024
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa. The CRISPR journal\| PubMed ID: 38108516	2023
A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease. Ophthalmology\| PubMed ID: 38309476	2024
Influence of Substrate Stiffness on iPSC-Derived Retinal Pigmented Epithelial Cells. Stem cells translational medicine\| PubMed ID: 38560893	2024
NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development. The Journal of clinical investigation\| PubMed ID: 38652563	2024
Belzutifan in Individuals with von Hippel-Lindau Retinal Hemangioblastomas: Institutional Experience and Review of the Literature. Ocular oncology and pathology\| PubMed ID: 39224523	2024
Exonic splice variant discovery using in vitro models of inherited retinal disease. HGG advances\| PubMed ID: 39354715	2025
Ghost vessels in the eye: Cell free choriocapillaris domains in atrophic age-related macular degeneration. Experimental eye research\| PubMed ID: 39419369	2024
Conditional Immortalization Using SV40 Large T Antigen and Its Effects on Induced Pluripotent Stem Cell Differentiation Toward Retinal Progenitor Cells. Stem cells and development\| PubMed ID: 39611948	2025
Elevation of Granulocyte Colony Stimulating Factor in Human AMD Donor RPE-Choroid. Investigative ophthalmology & visual science\| PubMed ID: 39641748	2024
Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration. Acta biomaterialia\| PubMed ID: 39710218	2025