Manuela Teresa Raimondi

Department of Chemistry, Politecnico di Milano

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
The effect of media perfusion on three-dimensional cultures of human chondrocytes: integration of experimental and computational approaches. Biorheology\| PubMed ID: 15299272	2004
Contact pressures at grafted cartilage lesions in the knee. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA\| PubMed ID: 16170578	2005
Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnology and bioengineering\| PubMed ID: 16224789	2006
Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors. Journal of biomechanics\| PubMed ID: 16389082	2006
Biomechanical analysis of cages for posterior lumbar interbody fusion. Medical engineering & physics\| PubMed ID: 16563847	2007
Loss in mechanical contact of cementless acetabular prostheses due to post-operative weight bearing: a biomechanical model. Medical engineering & physics\| PubMed ID: 16569508	2007
The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. Biorheology\| PubMed ID: 16912395	2006
Engineered tissue as a model to study cell and tissue function from a biophysical perspective. Current drug discovery technologies\| PubMed ID: 17430102	2006
Engineered cartilage constructs subject to very low regimens of interstitial perfusion. Biorheology\| PubMed ID: 18836246	2008
Comparative chondrogenesis of human cells in a 3D integrated experimental-computational mechanobiology model. Biomechanics and modeling in mechanobiology\| PubMed ID: 20549292	2011
Breakthroughs in computational modeling of cartilage regeneration in perfused bioreactors. IEEE transactions on bio-medical engineering\| PubMed ID: 21813363	2011
Two-photon laser polymerization: from fundamentals to biomedical application in tissue engineering and regenerative medicine. Journal of applied biomaterials & functional materials\| PubMed ID: 22562455	2012
Three-dimensional structural niches engineered via two-photon laser polymerization promote stem cell homing. Acta biomaterialia\| PubMed ID: 22922332	2013
An opto-structural method to estimate the stress-strain field induced by cell contraction on substrates of controlled stiffness in vitro. Journal of applied biomaterials & functional materials\| PubMed ID: 23413127	2013
Characterization of articular chondrocytes isolated from 211 osteoarthritic patients. Cell and tissue banking\| PubMed ID: 23549979	2014
Autologous intramuscular transplantation of engineered satellite cells induces exosome-mediated systemic expression of Fukutin-related protein and rescues disease phenotype in a murine model... Human molecular genetics\| PubMed ID: 28666318	2017
Scaling-Up Techniques for the Nanofabrication of Cell Culture Substrates via Two-Photon Polymerization for Industrial-Scale Expansion of Stem Cells. Materials (Basel, Switzerland)\| PubMed ID: 28772424	2017
Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson's disease related toxin 6-hydroxydopamine. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 28965958
Human bone perivascular niche-on-a-chip for studying metastatic colonization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29363599	2018
Development and biological validation of a cyclic stretch culture system for the ex vivo engineering of tendons. The International journal of artificial organs\| PubMed ID: 29781355
The effect of polyurethane scaffold surface treatments on the adhesion of chondrocytes subjected to interstitial perfusion culture. Tissue engineering and regenerative medicine\| PubMed ID: 30603418	2016
Influence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture. Biomedical microdevices\| PubMed ID: 30868253	2019
An Organ-On-A-Chip Engineered Platform to Study the Microbiota-Gut-Brain Axis in Neurodegeneration. Trends in molecular medicine\| PubMed ID: 31422037	2019
Mechanical regulation of nucleocytoplasmic translocation in mesenchymal stem cells: characterization and methods for investigation. Biophysical reviews\| PubMed ID: 31628607	2019
iPS, organoids and 3D models as advanced tools for in vitro toxicology. ALTEX\| PubMed ID: 31960938	2020
Advantages and limitations of a supernegative GFP in facilitating MyoD intracellular tracking. Methods and applications in fluorescence\| PubMed ID: 32092706	2020
Lamin A/C Mechanotransduction in Laminopathies. Cells\| PubMed ID: 32456328	2020
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19. Theranostics\| PubMed ID: 32641977	2020
Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases. Cells\| PubMed ID: 32646008	2020
Effect of the 3D Artificial Nichoid on the Morphology and Mechanobiological Response of Mesenchymal Stem Cells Cultured In Vitro. Cells\| PubMed ID: 32796521	2020
Dissecting the Effect of a 3D Microscaffold on the Transcriptome of Neural Stem Cells with Computational Approaches: A Focus on Mechanotransduction. International journal of molecular sciences\| PubMed ID: 32942778	2020
Nonlinear Optical Microscopy: From Fundamentals to Applications in Live Bioimaging. Frontiers in bioengineering and biotechnology\| PubMed ID: 33163482	2020
Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy . Nanotheranostics\| PubMed ID: 33391972	2021
The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche. Scientific reports\| PubMed ID: 33542304	2021
Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip. Lab on a chip\| PubMed ID: 33605282
Transcriptome Analysis of Subcutaneous Adipose Tissue from Severely Obese Patients Highlights Deregulation Profiles in Coding and Non-Coding Oncogenes. International journal of molecular sciences\| PubMed ID: 33671464	2021
RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs. Journal of personalized medicine\| PubMed ID: 33924951	2021
A Human Neurovascular Unit On-a-Chip. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34520009	2022
Transcriptional characterization of subcutaneous adipose tissue in obesity affected women highlights metabolic dysfunction and implications for lncRNAs. Genomics\| PubMed ID: 34555498	2021
Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growt... Biomedicines\| PubMed ID: 34572306	2021
α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease. Aging cell\| PubMed ID: 34799977	2021
RNA-seq dataset of subcutaneous adipose tissue: Transcriptional differences between obesity and healthy women. Data in brief\| PubMed ID: 34901353	2021
Characterization of the Microflow Through 3D Synthetic Niche Microenvironments Hosted in a Millifluidic Bioreactor. Frontiers in bioengineering and biotechnology\| PubMed ID: 34976990	2021
RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1. Cells\| PubMed ID: 35053410	2022
Patients' Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis. International journal of molecular sciences\| PubMed ID: 35628156	2022
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation. Antioxidants & redox signaling\| PubMed ID: 35793106	2023
Effect of 3D Synthetic Microscaffold Nichoid on the Morphology of Cultured Hippocampal Neurons and Astrocytes. Cells\| PubMed ID: 35805092	2022
Pectin-based bioinks for 3D models of neural tissue produced by a pH-controlled kinetics. Frontiers in bioengineering and biotechnology\| PubMed ID: 36619394	2022
Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1. Neurobiology of disease\| PubMed ID: 36736597	2023
Unravelling the mechanotransduction pathways in Alzheimer's disease. Journal of biological engineering\| PubMed ID: 36978103	2023
Bone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response. Regenerative engineering and translational medicine\| PubMed ID: 37363698	2023
3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells. APL bioengineering\| PubMed ID: 37692376	2023
label-free tissue histology through a microstructured imaging window. APL bioengineering\| PubMed ID: 38222895	2024
The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells. Genes\| PubMed ID: 38397189	2024
Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment. Nanoscale\| PubMed ID: 38884523	2024
The molecular basis of the anticancer effect of statins. Scientific reports\| PubMed ID: 39217242	2024
Non-Negative Matrix Tri-Factorization for Representation Learning in Multi-Omics Datasets with Applications to Drug Repurposing and Selection. International journal of molecular sciences\| PubMed ID: 39273521	2024
A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34 hematopoietic cells while allowing the detection of tumorigenic expansion. Frontiers in bioengineering and biotechnology\| PubMed ID: 39416278	2024
A 3D millifluidic model of a dermal perivascular microenvironment on a chip. Lab on a chip\| PubMed ID: 39757968	2025

Article	Year
The effect of media perfusion on three-dimensional cultures of human chondrocytes: integration of experimental and computational approaches. Biorheology\| PubMed ID: 15299272	2004
Contact pressures at grafted cartilage lesions in the knee. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA\| PubMed ID: 16170578	2005
Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnology and bioengineering\| PubMed ID: 16224789	2006
Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors. Journal of biomechanics\| PubMed ID: 16389082	2006
Biomechanical analysis of cages for posterior lumbar interbody fusion. Medical engineering & physics\| PubMed ID: 16563847	2007
Loss in mechanical contact of cementless acetabular prostheses due to post-operative weight bearing: a biomechanical model. Medical engineering & physics\| PubMed ID: 16569508	2007
The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. Biorheology\| PubMed ID: 16912395	2006
Engineered tissue as a model to study cell and tissue function from a biophysical perspective. Current drug discovery technologies\| PubMed ID: 17430102	2006
Engineered cartilage constructs subject to very low regimens of interstitial perfusion. Biorheology\| PubMed ID: 18836246	2008
Comparative chondrogenesis of human cells in a 3D integrated experimental-computational mechanobiology model. Biomechanics and modeling in mechanobiology\| PubMed ID: 20549292	2011
Breakthroughs in computational modeling of cartilage regeneration in perfused bioreactors. IEEE transactions on bio-medical engineering\| PubMed ID: 21813363	2011
Two-photon laser polymerization: from fundamentals to biomedical application in tissue engineering and regenerative medicine. Journal of applied biomaterials & functional materials\| PubMed ID: 22562455	2012
Three-dimensional structural niches engineered via two-photon laser polymerization promote stem cell homing. Acta biomaterialia\| PubMed ID: 22922332	2013
An opto-structural method to estimate the stress-strain field induced by cell contraction on substrates of controlled stiffness in vitro. Journal of applied biomaterials & functional materials\| PubMed ID: 23413127	2013
Characterization of articular chondrocytes isolated from 211 osteoarthritic patients. Cell and tissue banking\| PubMed ID: 23549979	2014
Autologous intramuscular transplantation of engineered satellite cells induces exosome-mediated systemic expression of Fukutin-related protein and rescues disease phenotype in a murine model... Human molecular genetics\| PubMed ID: 28666318	2017
Scaling-Up Techniques for the Nanofabrication of Cell Culture Substrates via Two-Photon Polymerization for Industrial-Scale Expansion of Stem Cells. Materials (Basel, Switzerland)\| PubMed ID: 28772424	2017
Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson's disease related toxin 6-hydroxydopamine. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 28965958
Human bone perivascular niche-on-a-chip for studying metastatic colonization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29363599	2018
Development and biological validation of a cyclic stretch culture system for the ex vivo engineering of tendons. The International journal of artificial organs\| PubMed ID: 29781355
The effect of polyurethane scaffold surface treatments on the adhesion of chondrocytes subjected to interstitial perfusion culture. Tissue engineering and regenerative medicine\| PubMed ID: 30603418	2016
Influence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture. Biomedical microdevices\| PubMed ID: 30868253	2019
An Organ-On-A-Chip Engineered Platform to Study the Microbiota-Gut-Brain Axis in Neurodegeneration. Trends in molecular medicine\| PubMed ID: 31422037	2019
Mechanical regulation of nucleocytoplasmic translocation in mesenchymal stem cells: characterization and methods for investigation. Biophysical reviews\| PubMed ID: 31628607	2019
iPS, organoids and 3D models as advanced tools for in vitro toxicology. ALTEX\| PubMed ID: 31960938	2020
Advantages and limitations of a supernegative GFP in facilitating MyoD intracellular tracking. Methods and applications in fluorescence\| PubMed ID: 32092706	2020
Lamin A/C Mechanotransduction in Laminopathies. Cells\| PubMed ID: 32456328	2020
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19. Theranostics\| PubMed ID: 32641977	2020
Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases. Cells\| PubMed ID: 32646008	2020
Effect of the 3D Artificial Nichoid on the Morphology and Mechanobiological Response of Mesenchymal Stem Cells Cultured In Vitro. Cells\| PubMed ID: 32796521	2020
Dissecting the Effect of a 3D Microscaffold on the Transcriptome of Neural Stem Cells with Computational Approaches: A Focus on Mechanotransduction. International journal of molecular sciences\| PubMed ID: 32942778	2020
Nonlinear Optical Microscopy: From Fundamentals to Applications in Live Bioimaging. Frontiers in bioengineering and biotechnology\| PubMed ID: 33163482	2020
Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy . Nanotheranostics\| PubMed ID: 33391972	2021
The nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche. Scientific reports\| PubMed ID: 33542304	2021
Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip. Lab on a chip\| PubMed ID: 33605282
Transcriptome Analysis of Subcutaneous Adipose Tissue from Severely Obese Patients Highlights Deregulation Profiles in Coding and Non-Coding Oncogenes. International journal of molecular sciences\| PubMed ID: 33671464	2021
RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs. Journal of personalized medicine\| PubMed ID: 33924951	2021
A Human Neurovascular Unit On-a-Chip. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34520009	2022
Transcriptional characterization of subcutaneous adipose tissue in obesity affected women highlights metabolic dysfunction and implications for lncRNAs. Genomics\| PubMed ID: 34555498	2021
Neural Precursor Cells Expanded Inside the 3D Micro-Scaffold Nichoid Present Different Non-Coding RNAs Profiles and Transcript Isoforms Expression: Possible Epigenetic Modulation by 3D Growt... Biomedicines\| PubMed ID: 34572306	2021
α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease. Aging cell\| PubMed ID: 34799977	2021
RNA-seq dataset of subcutaneous adipose tissue: Transcriptional differences between obesity and healthy women. Data in brief\| PubMed ID: 34901353	2021
Characterization of the Microflow Through 3D Synthetic Niche Microenvironments Hosted in a Millifluidic Bioreactor. Frontiers in bioengineering and biotechnology\| PubMed ID: 34976990	2021
RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1. Cells\| PubMed ID: 35053410	2022
Patients' Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis. International journal of molecular sciences\| PubMed ID: 35628156	2022
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation. Antioxidants & redox signaling\| PubMed ID: 35793106	2023
Effect of 3D Synthetic Microscaffold Nichoid on the Morphology of Cultured Hippocampal Neurons and Astrocytes. Cells\| PubMed ID: 35805092	2022
Pectin-based bioinks for 3D models of neural tissue produced by a pH-controlled kinetics. Frontiers in bioengineering and biotechnology\| PubMed ID: 36619394	2022
Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1. Neurobiology of disease\| PubMed ID: 36736597	2023
Unravelling the mechanotransduction pathways in Alzheimer's disease. Journal of biological engineering\| PubMed ID: 36978103	2023
Bone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response. Regenerative engineering and translational medicine\| PubMed ID: 37363698	2023
3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells. APL bioengineering\| PubMed ID: 37692376	2023
label-free tissue histology through a microstructured imaging window. APL bioengineering\| PubMed ID: 38222895	2024
The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells. Genes\| PubMed ID: 38397189	2024
Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment. Nanoscale\| PubMed ID: 38884523	2024
The molecular basis of the anticancer effect of statins. Scientific reports\| PubMed ID: 39217242	2024
Non-Negative Matrix Tri-Factorization for Representation Learning in Multi-Omics Datasets with Applications to Drug Repurposing and Selection. International journal of molecular sciences\| PubMed ID: 39273521	2024
A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34 hematopoietic cells while allowing the detection of tumorigenic expansion. Frontiers in bioengineering and biotechnology\| PubMed ID: 39416278	2024
A 3D millifluidic model of a dermal perivascular microenvironment on a chip. Lab on a chip\| PubMed ID: 39757968	2025