real-time-cardiac-mapping-with-noninvasive-imageless

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Rapid, safe, and effective cardiac mapping is critical for the management of complex arrhythmias, yet current methods face significant limitations. The ...

Corify Care SL

Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)

Premature ventricular contractions (PVCs) represent a common and clinically significant cardiac arrhythmia, contributing to a spectrum of cardiovascular disorders. Accurate localization of the origin of PVCs is essential for devising targeted therapeutic strategies and refining our comprehension of ventricular arrhythmogenesis. Traditionally, the 12-lead ECG has been the go-to diagnostic tool for PVCs. However, individual anatomical differences and inter-patient electrophysiology variability limit its effectiveness. This study presents a new method that combines electrocardiographic imaging (ECGI) with the concept of cardiac digital twins (ECGI-DT) to improve the accuracy of pinpointing the source of PVCs. By simulating a database of PVCs, we developed an ECGI-DT capable of estimating the origins of PVCs with much greater precision than possible previously. This study shows a notable improvement in identifying the initial site of PVC origin using ECGI-DT compared to ECGI alone: the average localization error dropped from 30.69 ± 23.71 mm with standard ECGI to 7.81 ± 3.82 mm using the ECGI-DT method. This marked reduction in error highlights the potential of ECGI-DT in revolutionizing PVC diagnosis and treatment. With its ability to provide more accurate and reliable data, ECGI-DT could improve the planning of catheter ablation treatments, a preferred intervention for managing PVCs that face challenges such as high costs and in some cases long procedure times.

Felipe Atienza

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