hybrid-petmri-imaging-of-alzheimer-s-disease-based-on-18f-av-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on <sup>18</sup>F-AV-1451

Alzheimer&#39;s disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by cognitive dysfunction, decline in daily living ...

General Hospital of Northern Theater Command

BackgroundTau pathology is closely associated with brain atrophy and cognitive decline, but how it specifically influences local and distant gray matter volume (GMV) and cognitive function remains unclear.ObjectiveThis study aims to explore the spatial relationships between tau pathology, GMV and cognition using hybrid positron emission tomography/magnetic resonance imaging (PET/MRI).MethodsTwenty amyloid-β (Aβ)-positive Alzheimer's disease (AD) patients, 14 mild cognitive impairment (MCI) patients, and 22 Aβ-negative normal controls (NC) underwent standardized neuropsychological assessments and F-fortaucipir PET/MRI scans. We investigated the associations between regional tau standardized uptake value ratio (SUVR) and GMV in AD signature regions. Mediation analyses were conducted to explore the potential mediating effects of local and distant GMV in the relationship between tau pathology and cognition.ResultsThe study indicated that increased F-fortaucipir SUVR and decreased GMV were related to cognitive performance in MCI and AD patients. Compared to NC group, the number of brain regions with local and distant correlations between GMV and SUVR was greater in AD/MCI group. Mediation analysis revealed that GMV served as a significant mediator between tau pathology and cognition in local regions. Furthermore, distant effects were also observed, with hippocampal atrophy partially mediated the relationship between entorhinal cortex tau pathology and cognition. Meanwhile, medial parietal lobe atrophy partially mediated the relationship between medial temporal lobe tau deposition and cognition.ConclusionsOur findings provide an anatomically detailed insight into relationships between tau, GMV and cognition, especially in entorhinal cortex-hippocampus, temporal-parietal lobe cortical circuits.

Local and distant atrophy mediate the relationship between tau pathology and cognition in temporoparietal region in Alzheimer's disease.

Myocardial fibrosis contributes to LV mechanical dyssynchrony and fibroblast activation protein is considered as a specific biomarker related to tissue remodeling. The authors aimed to explore the relationship between LVMD and myocardial fibrosis, and patterns of LV fibrosis distribution in CAD and Degenerative Mitral Valve Regurgitant (DMVR) participants by the technique of F-AlF-FAPI PET/MR.

Simultaneous F-labeled AlF-FAPI PET/MR images targeting the myocardial fibrosis in coronary artery disease and degenerative mitral valve regurgitant participants with left ventricular mechanical dyssynchrony.

Article	Year
Local and distant atrophy mediate the relationship between tau pathology and cognition in temporoparietal region in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 40116643	2025
Simultaneous F-labeled AlF-FAPI PET/MR images targeting the myocardial fibrosis in coronary artery disease and degenerative mitral valve regurgitant participants with left ventricular mechan... Clinics (Sao Paulo, Brazil)\| PubMed ID: 40138865	2025

Qingxue Shi

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