Thomas Dick

Center for Discovery and Innovation, Hackensack Meridian Health

Affiliated withHackensack Meridian Health Hackensack Meridian School of Medicine Georgetown University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2025

Other Publications

Article	Year
Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 31182531	2019
Repositioning rifamycins for Mycobacterium abscessus lung disease. Expert opinion on drug discovery\| PubMed ID: 31195849	2019
Editorial: NTM-The New Uber-Bugs. Frontiers in microbiology\| PubMed ID: 31249560	2019
TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of F-ATP Synthase. Antimicrobial agents and chemotherapy\| PubMed ID: 31358589	2019
Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance. Antimicrobial agents and chemotherapy\| PubMed ID: 31405862	2019
Phase variation in produces transiently heritable drug tolerance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31488707	2019
Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide. Trends in pharmacological sciences\| PubMed ID: 31704175	2019
TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrobial agents and chemotherapy\| PubMed ID: 31712198	2020
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis. Scientific reports\| PubMed ID: 31727946	2019
Targeted protein degradation in antibacterial drug discovery? Progress in biophysics and molecular biology\| PubMed ID: 31738980	2020
Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design. Progress in biophysics and molecular biology\| PubMed ID: 31743686	2020
Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase. Biochemical and biophysical research communications\| PubMed ID: 31761325	2020
Rifabutin Is Active against Mycobacterium abscessus in Mice. Antimicrobial agents and chemotherapy\| PubMed ID: 31767722	2020
Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline. Antibiotics (Basel, Switzerland)\| PubMed ID: 31835707	2019
TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 31964791	2020
Rifabutin Suppresses Inducible Clarithromycin Resistance in by Blocking Induction of and . Antibiotics (Basel, Switzerland)\| PubMed ID: 32050554	2020
Reply to Vargas and Farhat: mutants in human tuberculosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32075921	2020
Antituberculosis Activity of the Antimalaria Cytochrome Oxidase Inhibitor SCR0911. ACS infectious diseases\| PubMed ID: 32092260	2020
Rifabutin: A Repurposing Candidate for Lung Disease. Frontiers in microbiology\| PubMed ID: 32174907	2020
Extreme Drug Tolerance of "Persisters". Frontiers in microbiology\| PubMed ID: 32194537	2020
Pyrazinamide triggers degradation of its target aspartate decarboxylase. Nature communications\| PubMed ID: 32245967	2020
Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines. Angewandte Chemie (International ed. in English)\| PubMed ID: 32337801	2020
Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition. ACS infectious diseases\| PubMed ID: 32413266	2020
A systematic assessment of mycobacterial F -ATPase subunit ε's role in latent ATPase hydrolysis. The FEBS journal\| PubMed ID: 32525613	2021
Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 32958714	2020
Single Cell Analysis of Drug Susceptibility of During Macrophage Infection. Antibiotics (Basel, Switzerland)\| PubMed ID: 33080864	2020
Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties. Frontiers in microbiology\| PubMed ID: 33193190	2020
A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity. Antimicrobial agents and chemotherapy\| PubMed ID: 33558292	2023
PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor. ACS chemical biology\| PubMed ID: 33984234	2021
Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 34001512	2021
Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility. ACS medicinal chemistry letters\| PubMed ID: 34055215	2021
Reinvestigation of the structure-activity relationships of isoniazid. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 34116482	2021
A Ginger Root or Plum Model for the Tuberculosis "Granuloma"? American journal of respiratory and critical care medicine\| PubMed ID: 34153207	2021
Potency boost of a dihydrofolate reductase inhibitor by multienzyme FH-dependent reduction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34161270	2021
Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 34228543	2021
Epetraborole Is Active against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 34280020	2021
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 34606340	2021
Critical discussion on drug efflux in Mycobacterium tuberculosis. FEMS microbiology reviews\| PubMed ID: 34637511	2022
Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against . Journal of medicinal chemistry\| PubMed ID: 34706190	2021
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice. Antimicrobial agents and chemotherapy\| PubMed ID: 34723632	2022
Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus. Microbiology spectrum\| PubMed ID: 35019671	2022
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study. Antimicrobial agents and chemotherapy\| PubMed ID: 35099272	2022
Mutational Analysis of Mycobacterial F-ATP Synthase Subunit δ Leads to a Potent δ Enzyme Inhibitor. ACS chemical biology\| PubMed ID: 35148057	2022
Structure-Activity Relationship of Anti- Piperidine-4-carboxamides, a New Class of NBTI DNA Gyrase Inhibitors. ACS medicinal chemistry letters\| PubMed ID: 35300094	2022
Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1. Antimicrobial agents and chemotherapy\| PubMed ID: 35481752	2022
Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue. The Journal of experimental medicine\| PubMed ID: 35543723	2022
Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor. The FEBS journal\| PubMed ID: 35612822	2022
Structural and Mechanistic Insights into Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor. ACS infectious diseases\| PubMed ID: 35731701	2022
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus. Antimicrobial agents and chemotherapy\| PubMed ID: 36005813	2022
Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease. Antimicrobial agents and chemotherapy\| PubMed ID: 36047786	2022
Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angewandte Chemie (International ed. in English)\| PubMed ID: 36222275	2022
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents. Bioorganic & medicinal chemistry\| PubMed ID: 36228522	2022
Why Matter Matters: Fast-Tracking Drug Discovery. Molecules (Basel, Switzerland)\| PubMed ID: 36296540	2022
Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus . Antimicrobial agents and chemotherapy\| PubMed ID: 36350151	2022
Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus. Microbiology spectrum\| PubMed ID: 36377951	2022
Redox Cycling Dioxonaphthoimidazoliums Disrupt Iron Homeostasis in Mycobacterium bovis Bacillus Calmette-Guérin. Microbiology spectrum\| PubMed ID: 36377959	2022
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatiz... European journal of medicinal chemistry\| PubMed ID: 36399878	2023
Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 36445139	2022
Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against . RSC medicinal chemistry\| PubMed ID: 36545436	2022
Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection. Antimicrobial agents and chemotherapy\| PubMed ID: 36688684	2023
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against and Malaria Parasites. ACS infectious diseases\| PubMed ID: 36706233	2023
Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections. Antimicrobial agents and chemotherapy\| PubMed ID: 36920191	2023
Synthesis and Characterization of Phenylalanine Amides Active against and Other Mycobacteria. Journal of medicinal chemistry\| PubMed ID: 37001025	2023
PROTAC antibiotics: the time is now. Expert opinion on drug discovery\| PubMed ID: 37027333	2023
Characterization of Resistance to Linezolid in Mycobacterium abscessus. Microbiology spectrum\| PubMed ID: 37458588	2023
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant in caseum surrogate. Antimicrobial agents and chemotherapy\| PubMed ID: 37493373	2023
Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins. Microbiology spectrum\| PubMed ID: 37681986	2023
GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876. Microbiology spectrum\| PubMed ID: 37982630	2023
Pharmacological validation of dihydrofolate reductase as a drug target in . Antimicrobial agents and chemotherapy\| PubMed ID: 38018963	2024
Oral β-Lactam Pairs for the Treatment of Mycobacterium avium Complex Pulmonary Disease. The Journal of infectious diseases\| PubMed ID: 38150401	2024
High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo. The Journal of biological chemistry\| PubMed ID: 38176652	2024
Synthesis and in vitro Metabolic Stability of Sterically Shielded Antimycobacterial Phenylalanine Amides. ChemMedChem\| PubMed ID: 38329388	2024
Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease. Nature reviews. Drug discovery\| PubMed ID: 38418662	2024
A pairwise approach to revitalize β-lactams for the treatment of TB. Antimicrobial agents and chemotherapy\| PubMed ID: 38690896	2024
Rifampicin has no role in treatment of complex pulmonary disease and bactericidal sterilising drugs are needed: a viewpoint. The European respiratory journal\| PubMed ID: 38697635	2024
Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 38729070	2024
Broad-Spectrum In Vitro Activity of α-Aroyl--Aryl-Phenylalanine Amides against Non-Tuberculous Mycobacteria and Comparative Analysis of RNA Polymerases. Antibiotics (Basel, Switzerland)\| PubMed ID: 38786132	2024
Splenic marginal zone B cells restrict Mycobacterium tuberculosis infection by shaping the cytokine pattern and cell-mediated immunity. Cell reports\| PubMed ID: 38959109	2024
Toward better cures for lung disease. Clinical microbiology reviews\| PubMed ID: 39360834	2024
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of . Antimicrobial agents and chemotherapy\| PubMed ID: 39470195	2024
Durlobactam to boost the clinical utility of standard of care β-lactams against lung disease. Antimicrobial agents and chemotherapy\| PubMed ID: 39565116	2025
Toward a Bactericidal Oral Drug Combination for the Treatment of Lung Disease. ACS infectious diseases\| PubMed ID: 40168319	2025