wireless-telemetry-device-implantation-fontan-ovine-model-for

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

While the Fontan procedure drastically improves life expectancy for patients with single ventricle, it is well recognized that the resulting circulation ...

surgical-implantation-wireless-system-for-portal-vein-pressure

Surgical Implantation of a Wireless System for Portal Vein Pressure Monitoring in a Chronic Fontan Ovine Model

The Fontan circulation is characterized by nonpulsatile pulmonary blood flow and chronic systemic venous congestion, which has been associated with ...

Abigail Wexner Research Institute at Nationwide Children's Hospital

The Ohio State University Wexner Medical Center

Stem cell-based therapies are an emerging treatment modality aimed at replenishing lost cardiomyocytes and improving myocardial function after cardiac injury. This review examines the current state of research on injectable stem cell therapies in the setting of cardiovascular disease given their relative simplicity and ability for deep myocardial tissue penetration. Various methods of cell delivery, ranging in level of invasiveness and procedural complexity, have been developed, and numerous cell types have been studied as potential sources of stem cells, each with distinct advantages and disadvantages. We discuss key challenges associated with this approach, including low stem cell retention after transplantation and the innovative biomolecular strategies that have been explored to address this issue. Overall, investigations into the application of stem cells toward cardiac regeneration remain predominantly in the preclinical stage with a number of small, early-phase clinical trials. However, continued scientific advancements in stem cell technology may provide transformative treatment options for patients with heart failure, offering improved survival and quality of life.

ArticleTotal : 2	Year
Publication title Cited by 1	2025
Publication title	2025

Marissa Guo

Biography

JoVE Journal Publications

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