David S. Ziegler

Children's Cancer Institute Australia, UNSW Sydney

Affiliated withUNSW Sydney Sydney Children's Hospital

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Anti-apoptosis mechanisms in malignant gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18202424	2008
Reduced incidence of second solid tumors in survivors of childhood Hodgkin's lymphoma treated without radiation therapy. Annals of oncology : official journal of the European Society for Medical Oncology\| PubMed ID: 21393381	2011
Outcomes in multifocal neuroblastoma as part of the neurocristopathy syndrome. Pediatrics\| PubMed ID: 25070313	2014
Never say never. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 25559802	2015
Case Report of Spontaneous Resolution of a Congenital Glioblastoma. Pediatrics\| PubMed ID: 26980879	2016
Too many targets, not enough patients: rethinking neuroblastoma clinical trials. Nature reviews. Cancer\| PubMed ID: 29632319	2018
Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma. British journal of cancer\| PubMed ID: 30220707	2018
International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma. Journal of neuro-oncology\| PubMed ID: 30446898	2019
Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma. Journal of neuro-oncology\| PubMed ID: 30484110	2019
Predictors of Success of Phase II Pediatric Oncology Clinical Trials. The oncologist\| PubMed ID: 30808815	2019
Piloting a parent and patient decision aid to support clinical trial decision making in childhood cancer. Psycho-oncology\| PubMed ID: 31099124	2019
Translating palbociclib to the clinic for DIPG - What is truly achievable? EBioMedicine\| PubMed ID: 31235425	2019
"Balancing Expectations with Actual Realities": Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial. Journal of personalized medicine\| PubMed ID: 32075154	2020
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer. Nature medicine\| PubMed ID: 33020650	2020
Recurrent fusions in pediatric sarcoma and brain tumors. Cold Spring Harbor molecular case studies\| PubMed ID: 33144287	2020
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell\| PubMed ID: 33259802	2020
Frontiers in the treatment of glioblastoma: Past, present and emerging. Advanced drug delivery reviews\| PubMed ID: 33486006	2021
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas. Nature communications\| PubMed ID: 33579942	2021
Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor. NPJ precision oncology\| PubMed ID: 33580196	2021
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. Cell reports\| PubMed ID: 33852836	2021
The important role of routine cytopathology in pediatric precision oncology. Cancer cytopathology\| PubMed ID: 34043284	2021
Parents' experiences of postmortem tumor donation for high-grade gliomas: benefits and suggested improvements. Neuro-oncology advances\| PubMed ID: 34458732	2021
Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis. Acta neuropathologica communications\| PubMed ID: 34493325	2021
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer. EMBO molecular medicine\| PubMed ID: 34927798	2022
Therapeutic Targets in Diffuse Midline Gliomas-An Emerging Landscape. Cancers\| PubMed ID: 34944870	2021
Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy. Theranostics\| PubMed ID: 35832071	2022
Parents' understanding of genome and exome sequencing for pediatric health conditions: a systematic review. European journal of human genetics : EJHG\| PubMed ID: 35999452	2022
What's in a Name? Parents' and Healthcare Professionals' Preferred Terminology for Pathogenic Variants in Childhood Cancer Predisposition Genes. Journal of personalized medicine\| PubMed ID: 36013276	2022
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science. Neoplasia (New York, N.Y.)\| PubMed ID: 36335802	2023
Quality of Life (QoL) of Children and Adolescents Participating in a Precision Medicine Trial for High-Risk Childhood Cancer. Cancers\| PubMed ID: 36358729	2022
Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes. Scientific reports\| PubMed ID: 36882456	2023
From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer. Advanced drug delivery reviews\| PubMed ID: 36931346	2023
loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma. Frontiers in oncology\| PubMed ID: 36937401	2023
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. Cancer cell\| PubMed ID: 37001527	2023
A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer. Genome medicine\| PubMed ID: 37013636	2023
LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients. Neuro-oncology\| PubMed ID: 37075810	2023
BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience. Frontiers in oncology\| PubMed ID: 37124503	2023
Afatinib in paediatric patients with recurrent/refractory ErbB-dysregulated tumours: Results of a phase I/expansion trial. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 37178647	2023
Parents' and adolescents' perspectives and understanding of information about childhood cancer precision medicine. Cancer\| PubMed ID: 37376781	2023
Parents' expectations, preferences, and recall of germline findings in a childhood cancer precision medicine trial. Cancer\| PubMed ID: 37382186	2023
Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial. Journal of personalized medicine\| PubMed ID: 37511646	2023
Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study... The Journal of molecular diagnostics : JMD\| PubMed ID: 37517472	2023
High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer. Cancer research\| PubMed ID: 37523146	2023
Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas. Molecular cancer therapeutics\| PubMed ID: 37683275	2023
Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives. British journal of cancer\| PubMed ID: 37726477	2023
Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium. Cancer discovery\| PubMed ID: 37823831	2024
A paradigm shift in how we treat pediatric low-grade glioma-Targeting the molecular drivers. Neuro-oncology\| PubMed ID: 38243845	2024
Communicating with families of young people with hard-to-treat cancers: Healthcare professionals' perspectives on challenges, skills, and training. Palliative & supportive care\| PubMed ID: 38263685	2024
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma. The Journal of clinical investigation\| PubMed ID: 38319732	2024
A Phase 1 Study of Intravenous EGFR-ErbituxEDVsMIT in Children with Solid or CNS Tumours Expressing Epidermal Growth Factor Receptor. Targeted oncology\| PubMed ID: 38546944	2024
Preclinical evaluation of protein synthesis inhibitor omacetaxine in pediatric brainstem gliomas. Neuro-oncology advances\| PubMed ID: 38550394	2024
Co-design of a paediatric oncology medicines database (ProCure) to support complex care provision for children with a hard-to-treat cancer. Frontiers in medicine\| PubMed ID: 38606155	2024
Development of Orthotopic Patient-Derived Xenograft Models of Pediatric Intracranial Tumors. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 38676797	2024
Precision-guided treatment in high-risk pediatric cancers. Nature medicine\| PubMed ID: 38844796	2024
Liver disease and transplantation in telomere biology disorders: An international multicenter cohort. Hepatology communications\| PubMed ID: 38896081	2024
The feasibility and acceptability of collecting psychosocial outcome measures embedded within a precision medicine trial for childhood cancer. Cancer medicine\| PubMed ID: 38898768	2024
Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 39110925	2024
Barriers to access of precision guided therapies for children with high-risk cancer. Pediatric blood & cancer\| PubMed ID: 39185694	2024
When genetics and pediatric cancer collide: Understanding and optimizing families' experiences. Neuro-oncology advances\| PubMed ID: 39220248	2024
Novel paediatric case of a spinal high-grade astrocytoma with piloid features in a patient with Noonan Syndrome. NPJ precision oncology\| PubMed ID: 39427038	2024
Impact of time to antibiotics on clinical outcome in paediatric febrile neutropenia: a target trial emulation of 1685 episodes. The Lancet regional health. Western Pacific\| PubMed ID: 39553416	2024
Second Opinion Seeking in Paediatric Oncology: Motivations and Predictors. Psycho-oncology\| PubMed ID: 39558466	2024
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 39625867	2025
Germline analysis of an international cohort of pediatric diffuse midline glioma patients. Neuro-oncology\| PubMed ID: 40072012	2025
The Super Enhancer-Driven Long Noncoding RNA PRKCQ-AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 40103284	2025
Whatever It Takes: Parents' Perspectives of Patient-Derived Xenograft Mouse Models for Poor Prognosis Childhood Cancer. JCO precision oncology\| PubMed ID: 40209140	2025