Gaya Amarasinghe

Department of Pathology and Immunology, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Molecular mechanisms of viral inhibitors of RIG-I-like receptors. Trends in microbiology\| PubMed ID: 22325030	2012
Aptamers in virology: recent advances and challenges. Frontiers in microbiology\| PubMed ID: 22347221	2012
Structural insights into RNA recognition and activation of RIG-I-like receptors. Current opinion in structural biology\| PubMed ID: 22560447	2012
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23185024	2012
An upstream open reading frame modulates ebola virus polymerase translation and virus replication. PLoS pathogens\| PubMed ID: 23382680	2013
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome. Cell host & microbe\| PubMed ID: 23870315	2013
Development of RNA aptamers targeting Ebola virus VP35. Biochemistry\| PubMed ID: 24067086	2013
A calcium-fortified viral matrix protein. Structure (London, England : 1993)\| PubMed ID: 24411575	2014
A viral RNA structural element alters host recognition of nonself RNA. Science (New York, N.Y.)\| PubMed ID: 24482115	2014
In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity. Journal of molecular biology\| PubMed ID: 24495995	2014
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell reports\| PubMed ID: 24630991	2014
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. Cell host & microbe\| PubMed ID: 25121748	2014
Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis. Journal of virology\| PubMed ID: 25741013	2015
Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. The Journal of biological chemistry\| PubMed ID: 25839233	2015
An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. Cell reports\| PubMed ID: 25865894	2015
Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Journal of virology\| PubMed ID: 26157117	2015
Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins. Cell reports\| PubMed ID: 26876165	2016
When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins. Current opinion in structural biology\| PubMed ID: 26916433	2016
Taxonomy of the order Mononegavirales: update 2016. Archives of virology\| PubMed ID: 27216929	2016
Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses. Journal of molecular biology\| PubMed ID: 27487481	2016
Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses. Journal of molecular biology\| PubMed ID: 27497688	2016
Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials. Systematic biology\| PubMed ID: 27798405	2017
VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability. Journal of virology\| PubMed ID: 27974555	2017
A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface. ACS infectious diseases\| PubMed ID: 28152588	2017
Taxonomy of the order Mononegavirales: update 2017. Archives of virology\| PubMed ID: 28389807	2017
Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses. Viruses\| PubMed ID: 28492506	2017
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nature communications\| PubMed ID: 28593988	2017
Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nature microbiology\| PubMed ID: 28665409	2017
Filovirus Strategies to Escape Antiviral Responses. Current topics in microbiology and immunology\| PubMed ID: 28685291	2017
Filovirus Structural Biology: The Molecules in the Machine. Current topics in microbiology and immunology\| PubMed ID: 28795188	2017
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nature immunology\| PubMed ID: 29255269	2018
Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication. Nature communications\| PubMed ID: 29386621	2018
Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell\| PubMed ID: 29474922	2018
LysMD3 is a type II membrane protein without an role in the response to a range of pathogens. The Journal of biological chemistry\| PubMed ID: 29496999	2018
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity\| PubMed ID: 29525521	2018
Taxonomy of the order Mononegavirales: update 2018. Archives of virology\| PubMed ID: 29637429	2018
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature\| PubMed ID: 29670287	2018
Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange. Cell reports\| PubMed ID: 29847807	2018
Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms. The Journal of infectious diseases\| PubMed ID: 29939318	2018
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Molecular cell\| PubMed ID: 30017584	2018
Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. mBio\| PubMed ID: 30018113	2018
Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes. Cell reports\| PubMed ID: 30044983	2018
Applications of Parametrized NMR Spin Systems of Small Molecules. Analytical chemistry\| PubMed ID: 30125102	2018
Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nature microbiology\| PubMed ID: 30224802	2018
Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nature microbiology\| PubMed ID: 30327492	2018
Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell\| PubMed ID: 30550789	2018
Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets. Antiviral research\| PubMed ID: 30550800	2019
Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities. Trends in biochemical sciences\| PubMed ID: 30555007	2019
Taxonomy of the order Mononegavirales: second update 2018. Archives of virology\| PubMed ID: 30663023	2019
Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor. Journal of molecular biology\| PubMed ID: 30928493	2019
Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600-739 construct. Biomolecular NMR assignments\| PubMed ID: 31076990	2019
Taxonomy of the order Mononegavirales: update 2019. Archives of virology\| PubMed ID: 31089958	2019
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell host & microbe\| PubMed ID: 31130511	2019
Ebola Virus Replication Stands Out. Trends in microbiology\| PubMed ID: 31155428	2019
Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription. Cellular and molecular life sciences : CMLS\| PubMed ID: 31562565	2020
Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner. ACS infectious diseases\| PubMed ID: 31899866	2020
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target. Cell reports\| PubMed ID: 31914382	2020
Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates. Antiviral research\| PubMed ID: 32446802	2020
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2. SSRN\| PubMed ID: 32714117	2020
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Cell host & microbe\| PubMed ID: 32735849	2020
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of virology\| PubMed ID: 32888050	2020
Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain. bioRxiv : the preprint server for biology\| PubMed ID: 33269347	2020
Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33649232	2021
Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell reports\| PubMed ID: 33691097	2021
Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain. iScience\| PubMed ID: 34095780	2021
Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection. The EMBO journal\| PubMed ID: 34260076	2021
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. Journal of molecular biology\| PubMed ID: 34329642	2021
2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of virology\| PubMed ID: 34463877	2021
Lrp1 is a host entry factor for Rift Valley fever virus. Cell\| PubMed ID: 34559985	2021
Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein. STAR protocols\| PubMed ID: 34642671	2021
Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription. Cell reports\| PubMed ID: 34644581	2021
Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of virology\| PubMed ID: 34786611	2021
Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong. Respirology (Carlton, Vic.)\| PubMed ID: 34820940	2022
Cryo-EM analysis of Ebola virus nucleocapsid-like assembly. STAR protocols\| PubMed ID: 34977676	2022
Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics. ACS infectious diseases\| PubMed ID: 35026950	2022
Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins. Journal of molecular biology\| PubMed ID: 35405107	2022
A cryptic pocket in Ebola VP35 allosterically controls RNA binding. Nature communications\| PubMed ID: 35477718	2022
Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies. mBio\| PubMed ID: 35536005	2022
Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies. Cell reports\| PubMed ID: 35617963	2022
SARS-CoV-2 accessory proteins reveal distinct serological signatures in children. Nature communications\| PubMed ID: 35618731	2022
Liquid Phase Partitioning in Virus Replication: Observations and Opportunities. Annual review of virology\| PubMed ID: 35709511	2022
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants. ACS chemical biology\| PubMed ID: 35731947	2022
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nature immunology\| PubMed ID: 35761082	2022
Rapid detection of an Ebola biomarker with optical microring resonators. Cell reports methods\| PubMed ID: 35784644	2022
Monoclonal antibodies binding data for SARS-CoV-2 proteins. Data in brief\| PubMed ID: 35789908	2022
The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nature communications\| PubMed ID: 35831295	2022
Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2. ACS infectious diseases\| PubMed ID: 35867632	2022
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 35939689	2022
Detection of biomarkers for filoviral infection with a silicon photonic resonator platform. STAR protocols\| PubMed ID: 36153732	2022
Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease. Journal of virology\| PubMed ID: 36194021	2022
Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. PLoS pathogens\| PubMed ID: 36548304	2022
Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population. Nature medicine\| PubMed ID: 36652990	2023
Biochemical and HDX Mass Spectral Characterization of the SARS-CoV-2 Nsp1 Protein. Biochemistry\| PubMed ID: 37205707	2023
Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24. Viruses\| PubMed ID: 37243162	2023
Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice. Science advances\| PubMed ID: 37450601	2023
Disruption of Ebola NPVP35 Inclusion Body-like Structures reduce Viral Infection. Journal of molecular biology\| PubMed ID: 37598728	2023
Elevated Level of Circulating but Not Urine S100A8/A9 Identifies Poor COVID-19 Outcomes. ACS infectious diseases\| PubMed ID: 37787461	2023
Host entry factors of Rift Valley Fever Virus infection. Advances in virus research\| PubMed ID: 37832991	2023
Author Correction: Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population. Nature medicine\| PubMed ID: 37875568	2024
A Flexible, Quantitative Plasmonic-Fluor Lateral Flow Assay for the Rapid Detection of and . ACS infectious diseases\| PubMed ID: 38048277	2024
Serological assays for differentiating natural COVID-19 infection from vaccine induced immunity. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 38056114	2024
Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity. Cells\| PubMed ID: 38201275	2023
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. bioRxiv : the preprint server for biology\| PubMed ID: 38617272	2024
Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination. Nature communications\| PubMed ID: 39379345	2024
Characterization of neural infection by Oropouche orthobunyavirus. bioRxiv : the preprint server for biology\| PubMed ID: 39416126	2024
Lrp1 facilitates infection of neurons by Jamestown Canyon virus. bioRxiv : the preprint server for biology\| PubMed ID: 39574651	2024
Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25. Nature communications\| PubMed ID: 40128225	2025