rapid-detection-fecal-antigen-helicobacter-pylori-infection-based-on

Rapid Detection of Fecal Antigen of <em>Helicobacter pylori</em> Infection Based on Double Antibody Sandwich Detection Technology

Helicobacter pylori can be parasitic in gastric mucosa, which can cause a series of gastrointestinal diseases after infection and is closely related to ...

Southern Medical University

The progression of gastric cancer involves a complex multi-stage process, with gastroscopy and biopsy being the standard procedures for diagnosing gastric diseases. This study introduces an innovative non-invasive approach to differentiate gastric disease stage using gastric fluid samples through machine-learning-assisted surface-enhanced Raman spectroscopy (SERS). This method effectively identifies different stages of gastric lesions. The XGBoost algorithm demonstrates the highest accuracy of 96.88% and 91.67%, respectively, in distinguishing chronic non-atrophic gastritis from intestinal metaplasia and different subtypes of gastritis (mild, moderate, and severe). Through blinded testing validation, the model can achieve more than 80% accuracy. These findings offer new possibilities for rapid, cost-effective, and minimally invasive diagnosis of gastric diseases.

Identification of chronic non-atrophic gastritis and intestinal metaplasia stages in the Correa's cascade through machine learning analyses of SERS spectral signature of non-invasively-collected human gastric fluid samples.

Helicobacter pylori (H. pylori) infection is widespread globally and can cause serious gastrointestinal complications, including gastric cancer. This study assesses the prevalence and antibiotic resistance of H. pylori in Guangdong, one of China's most developed provinces.

Epidemiological characteristics of Helicobacter pylori infection and antibiotic resistance in urban areas of Guangdong Province, China: a multi-center, cross-sectional surveillance.

To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population.

Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study.

Helicobacter pylori (H. pylori) infection has long been a significant global public health concern, with antibiotic resistance becoming increasingly severe. Gastric fluid qPCR detection can provide information on H. pylori infection and antibiotic resistance.

Detection of Helicobacter pylori Infection and Antibiotic Resistance via String Test Coupled With qPCR Method: A Comparative Methodological Study.

 (), linked to gastric cancer, lacks regional data on infection rates, resistance, and risks in Dongying, China.

Article	Year
Identification of chronic non-atrophic gastritis and intestinal metaplasia stages in the Correa's cascade through machine learning analyses of SERS spectral signature of non-invasively-colle... Biosensors & bioelectronics\| PubMed ID: 38943854	2024
Epidemiological characteristics of Helicobacter pylori infection and antibiotic resistance in urban areas of Guangdong Province, China: a multi-center, cross-sectional surveillance. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology\| PubMed ID: 40080302	2025
Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases\| PubMed ID: 40096882	2025
Detection of Helicobacter pylori Infection and Antibiotic Resistance via String Test Coupled With qPCR Method: A Comparative Methodological Study. Journal of gastroenterology and hepatology\| PubMed ID: 40170571	2025
Current rates of infection and antibiotic resistance in the eastern coast of China: a single center study. Frontiers in cellular and infection microbiology\| PubMed ID: 40292221	2025

Jinxin Lai

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