preventing-hemorrhage-after-endoscopic-submucosal-dissection-using

Preventing Hemorrhage After Endoscopic Submucosal Dissection Using Polysaccharide Hemostatic Materials

Endoscopic submucosal dissection (ESD) is a minimally invasive procedure that is widely used for the treatment of early gastric cancer and certain ...

titanium-clip-dental-floss-traction-assisted-endoscopic-submucosal

Titanium Clip and Dental Floss Traction Assisted Endoscopic Submucosal Dissection Resection for Early Gastric Cancer

Endoscopic mucosal dissection (ESD) is used to diagnose and treat early gastrointestinal tumors. ESD allows for curative resection of superficial ...

Shanghai Civil Aviation Hospital

Gubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Prior observational studies have reported the potential protective effect of -3 fatty acids on the prognosis of acute pancreatitis (AP). However, the causal impact of -3 fatty acids on AP is unclear. We aimed to investigate further the association of -3 fatty acids with AP. We performed a meta-analysis and Mendelian randomisation (MR) to explore the association between -3 fatty acids and the prognosis of AP from clinical observation and genetics perspectives, respectively. Nine randomised controlled trials were included in this study. The result meta-analysis showed that complementary therapy of -3 fatty acids significantly decreased mortality (Relative Risk (RR): 0·30; 95 % CI 0·14, 0·65,  < 0·05) and infectious complications in AP (RR: 0·45; 95 % CI 0·27, 0·77,  < 0·05). Compared with the control groups, the hospital stays (MD: -1·02; 95 % CI -1·85, -0·20,  < 0·05) in AP patients with -3 fatty acids treatment were statistically reduced. However, the ICU stay (MD: -0·49; 95 % CI -1·29, -0·31,  > 0·05) between control groups and AP patients with -3 fatty acids treatment was insignificant. Utilising genetic susceptibility analysis in the MR approach, the MR showed -3 fatty acids have a significant causal effect on the AP risk (OR, 0·887; 95 % CI 0·797, 0·986,  = 0·027, fixed-effect; OR, 0·887; 95 % CI 0·792, 0·993,  = 0·037, random-effect). -3 fatty acids complementary therapy may improve the prognosis of AP. Furthermore, genetically predicted serum levels of -3 fatty acids can significantly lower AP risk.

ArticleTotal : 2	Year
Publication title Cited by 1	2025
Publication title	2025

Wenyang Zhang

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