Keith R. McCrae

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. The Journal of clinical investigation\| PubMed ID: 18431509	2008
Impaired fibrinolysis in the antiphospholipid syndrome. Current rheumatology reports\| PubMed ID: 20425534	2010
Blind men and the APS. Blood\| PubMed ID: 20966177	2010
Thrombocytopenia in pregnancy. Hematology. American Society of Hematology. Education Program\| PubMed ID: 21239825	2010
Sutton's law and anti-β₂GPI antibodies. Blood\| PubMed ID: 21436079	2011
Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors. Blood\| PubMed ID: 21482710	2011
Immune thrombocytopenia: no longer 'idiopathic'. Cleveland Clinic journal of medicine\| PubMed ID: 21632906	2011
RhIG for the treatment of immune thrombocytopenia: consensus and controversy (CME). Transfusion\| PubMed ID: 21981825	2012
Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery\| PubMed ID: 22093380	2013
A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies. Blood\| PubMed ID: 22106343	2012
Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics. The Journal of biological chemistry\| PubMed ID: 22577144	2012
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood\| PubMed ID: 22936662	2012
Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders. Blood\| PubMed ID: 22966172	2012
Management and outcomes for patients with TTP: analysis of 100 cases at a single institution. American journal of hematology\| PubMed ID: 23605996	2013
Immune thrombocytopenia. Hematology/oncology clinics of North America\| PubMed ID: 23714309	2013
Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway. Blood\| PubMed ID: 23954892	2013
The least of 3 evils: exposure to red blood cell transfusion, anemia, or both? The Journal of thoracic and cardiovascular surgery\| PubMed ID: 23998782	2013
Better late than never? Blood\| PubMed ID: 24030254	2013
Risk stratification strategies for cancer-associated thrombosis: an update. Thrombosis research\| PubMed ID: 24862143	2014
Rituximab for treatment of inhibitors in haemophilia A. A Phase II study. Thrombosis and haemostasis\| PubMed ID: 24919980	2014
Recent advances in the antiphospholipid antibody syndrome. Current opinion in hematology\| PubMed ID: 25023470	2014
Antiplatelet antibodies in oxaliplatin-induced immune thrombocytopenia. JRSM open\| PubMed ID: 25057402	2014
Symptomatic and incidental venous thromboembolic disease are both associated with mortality in patients with prostate cancer. PloS one\| PubMed ID: 25126949	2014
Circulating microparticles in patients with antiphospholipid antibodies: characterization and associations. Thrombosis research\| PubMed ID: 25467081	2015
Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice. Journal of cellular and molecular medicine\| PubMed ID: 25702801	2015
Increased morbidity during long-term follow-up of survivors of thrombotic thrombocytopenic purpura. American journal of hematology\| PubMed ID: 26228638	2015
The antiphospholipid syndrome: still an enigma. Hematology. American Society of Hematology. Education Program\| PubMed ID: 26637701	2015
Recurrent venous thromboembolism in glioblastoma. Thrombosis research\| PubMed ID: 26657302	2016
FcγRIII in ITP: it ain't over 'til it's over. Blood\| PubMed ID: 26744437	2016
Predictors of recurrent venous thromboembolism and bleeding on anticoagulation. Thrombosis research\| PubMed ID: 27067987	2016
Treatment of chronic immune thrombocytopenia in children with romiplostim. Lancet (London, England)\| PubMed ID: 27103125	2016
Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27402674	2016
Evaluation of US prescription patterns: Are treatment guidelines for cancer-associated venous thromboembolism being followed? Thrombosis research\| PubMed ID: 27485998	2016
Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group. Cancer research\| PubMed ID: 27527638	2016
Blind men and the refractory ITP elephant. Blood\| PubMed ID: 27658695	2016
Centralizing care of cancer-associated thromboembolism: The Cleveland Clinic experience. Thrombosis research\| PubMed ID: 27721140	2016
In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 27925685	2017
Post-traumatic stress disorder and depression in survivors of thrombotic thrombocytopenic purpura. Thrombosis research\| PubMed ID: 28113083	2017
Predicting risk of venous thromboembolism in hospitalized cancer patients: Utility of a risk assessment tool. American journal of hematology\| PubMed ID: 28240823	2017
Depression and post-traumatic stress disorder in individuals with hereditary hemorrhagic telangiectasia: A cross-sectional survey. Thrombosis research\| PubMed ID: 28314138	2017
Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia. American journal of hematology\| PubMed ID: 28388835	2017
Extracellular Vesicles in the Antiphospholipid Syndrome. Seminars in thrombosis and hemostasis\| PubMed ID: 28476065	2018
Clinical Risk Assessment in the Antiphospholipid Syndrome: Current Landscape and Emerging Biomarkers. Current rheumatology reports\| PubMed ID: 28711993	2017
Diagnosis and management of the antiphospholipid syndrome. Blood reviews\| PubMed ID: 28784423	2017
CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors. The Journal of experimental medicine\| PubMed ID: 28838952	2017
Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 29122754	2018
Preoperative Anemia in Cardiac Operation: Does Hemoglobin Tell the Whole Story? The Annals of thoracic surgery\| PubMed ID: 29128046	2018
Splenectomy for immune thrombocytopenia: down but not out. Blood\| PubMed ID: 29295846	2018
Novel Mechanism of Cancer Thrombosis Induced by Microvesicles. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29563113	2018
Current practice patterns and patient persistence with anticoagulant treatments for cancer-associated thrombosis. Research and practice in thrombosis and haemostasis\| PubMed ID: 30046670	2017
Effects of anti-β2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity. Research and practice in thrombosis and haemostasis\| PubMed ID: 30046742	2018
Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 30354195	2018
Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 30358441	2019
Duration of anticoagulant therapy and VTE recurrence in patients with cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 30734088	2019
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 30801944	2019
Complement in the Pathophysiology of the Antiphospholipid Syndrome. Frontiers in immunology\| PubMed ID: 30923524	2019
Bleeding incidence and risk factors among cancer patients treated with anticoagulation. American journal of hematology\| PubMed ID: 31006890	2019
Implementation of an electronic medical record tool for early detection of deep vein thrombosis in the ambulatory oncology setting. Research and practice in thrombosis and haemostasis\| PubMed ID: 31011706	2019
Healthcare resource utilization and costs associated with venous thromboembolism in cancer patients treated with anticoagulants. Journal of medical economics\| PubMed ID: 31106638	2019
A non-circulating pool of factor XI associated with glycosaminoglycans in mice. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31125187	2019
Prognostic Value of Preoperative Red Cell Distribution Width: Fine-Tuning by Mean Corpuscular Volume. The Annals of thoracic surgery\| PubMed ID: 31199898	2019
American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood advances\| PubMed ID: 31794604	2019
Clinical outcomes of isolated distal deep vein thrombosis versus proximal venous thromboembolism in cancer patients: The Cleveland Clinic experience. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31808607	2020
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS. Blood\| PubMed ID: 31812994	2020
Healthcare resource utilization and costs associated with venous thromboembolism recurrence in patients with cancer. Journal of medical economics\| PubMed ID: 31818164	2020
Editorial: Proceedings of KININ2018CLE, Cleveland, Ohio, June 18-20, 2018: A Compendium of the Presentations. Frontiers in medicine\| PubMed ID: 31824955	2019
Outcomes of Cardiovascular Surgery Utilizing Heparin versus Direct Thrombin Inhibitors in Cardiopulmonary Bypass in Patients with Previously Diagnosed HIT. Thrombosis and haemostasis\| PubMed ID: 31887779	2020
RNA expression and risk of venous thromboembolism in lung cancer. Research and practice in thrombosis and haemostasis\| PubMed ID: 31989093	2020
"HIT"ing back against NETs. Blood\| PubMed ID: 32135015	2020
FcRn augments induction of tissue factor activity by IgG-containing immune complexes. Blood\| PubMed ID: 32187355	2020
Report of a 'consensus' on the lines of therapy for primary immune thrombocytopenia in adults, promoted by the Italian Gruppo di Studio delle Piastrine. Platelets\| PubMed ID: 32314933	2020
The J-elongated conformation of β-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. The Journal of biological chemistry\| PubMed ID: 32518155	2020
Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. Blood\| PubMed ID: 32559765	2020
Mechanisms and biomarkers of cancer-associated thrombosis. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 32645431	2020
SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy. EBioMedicine\| PubMed ID: 32771682	2020
Risk of thromboembolism in patients with ALK- and EGFR-mutant lung cancer: A cohort study. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 33314597	2021
SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Research square\| PubMed ID: 33398263	2020
Incidence of thromboembolism in patients with melanoma on immune checkpoint inhibitor therapy and its adverse association with survival. Journal for immunotherapy of cancer\| PubMed ID: 33436486	2021
Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method. Research and practice in thrombosis and haemostasis\| PubMed ID: 33537531	2021
Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. Blood\| PubMed ID: 33827130	2021
A novel "vascular" thrombophilia. Blood\| PubMed ID: 33885713	2021
Efficacy and Safety of Avatrombopag in Patients with Chronic Immune Thrombocytopenia: A Systematic Literature Review and Network Meta-Analysis. Advances in therapy\| PubMed ID: 33934279	2021
Thrombotic thrombocytopenia due to SARS-CoV-2 vaccination. Cleveland Clinic journal of medicine\| PubMed ID: 33958344	2021
Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19. Vascular medicine (London, England)\| PubMed ID: 34010070	2021
Increased Incidence of Venous Thromboembolism with Cancer Immunotherapy. Med (New York, N.Y.)\| PubMed ID: 34036293	2021
Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1. Frontiers in molecular biosciences\| PubMed ID: 34150849	2021
Sclerotherapy Versus Cautery/Laser Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia. The Laryngoscope\| PubMed ID: 34160081	2022
Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia. Angiogenesis\| PubMed ID: 34292451	2022
Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation. Blood advances\| PubMed ID: 34597365	2021
Biomarker signatures in cancer patients with and without venous thromboembolism events: a substudy of CASSINI. Blood advances\| PubMed ID: 34807979	2022
Eculizumab for refractory thrombosis in antiphospholipid syndrome. Blood advances\| PubMed ID: 35051999	2022
Race, rituximab, and relapse in TTP. Blood\| PubMed ID: 35797471	2022
Development and performance of a hereditary hemorrhagic telangiectasia-specific quality-of-life instrument. Blood advances\| PubMed ID: 35877137	2022
Old is new again: emergence of thromboembolic complications in cancer patients on immunotherapy. Thrombosis research\| PubMed ID: 36061419	2022
Emerging Therapies in Antiphospholipid Syndrome. Transfusion medicine reviews\| PubMed ID: 36272841	2022
Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo. Blood advances\| PubMed ID: 36409609	2023
C1 inhibitor deficiency enhances contact pathway-mediated activation of coagulation and venous thrombosis. Blood\| PubMed ID: 36701760	2023
Transcriptome analysis suggests a central role for complement and C5aR1 in neutrophil activation in APS. Thrombosis research\| PubMed ID: 37660437	2023
Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 37683721	2024
High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 37813198	2024
How to diagnose and manage antiphospholipid syndrome. Hematology. American Society of Hematology. Education Program\| PubMed ID: 38066904	2023
A descriptive analysis of fatal outcomes in immune thrombotic thrombocytopenic purpura in the USTMA TTP Registry. Blood advances\| PubMed ID: 38100454	2024
Dysregulated platelet function in patients with postacute sequelae of COVID-19. Vascular medicine (London, England)\| PubMed ID: 38334067	2024
The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia. Blood advances\| PubMed ID: 38608258	2024
A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura. Research and practice in thrombosis and haemostasis\| PubMed ID: 38651093	2024
A "backup plan" for ADAMTS13 deficiency in TTP. Blood\| PubMed ID: 38753355	2024
Catastrophic antiphospholipid syndrome: challenging case and importance of multidisciplinary evaluation and management. Clinical case reports\| PubMed ID: 38868115	2024
Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia. The New England journal of medicine\| PubMed ID: 39292928	2024
Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy. Blood\| PubMed ID: 39357054	2024
Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era. Blood advances\| PubMed ID: 39626301	2025
Pomalidomide in Hereditary Hemorrhagic Telangiectasia. Reply. The New England journal of medicine\| PubMed ID: 39665668	2024
Protection of β2GPI-deficient mice from thrombosis reflects a defect in PAR3-facilitated platelet activation. Blood\| PubMed ID: 39869832	2025
Idiopathic multicentric Castleman disease - TAFRO results in high levels of mTOR activator SVEP1, tissue factor, and endotheliopathy. Blood vessels, thrombosis & hemostasis\| PubMed ID: 40191177	2024
Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS). medRxiv : the preprint server for health sciences\| PubMed ID: 40385421	2025