Yan Gong

Tumor Precision Diagnosis and Treatment Technology and Translational Medicine, zhongnan hospital of Wuhan University

Affiliated withzhongnan hospital of Wuhan University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Role of Glioma-associated GLI1 Oncogene in Carcinogenesis and Cancertargeted Therapy. Current cancer drug targets\| PubMed ID: 29189160	2018
FePt-Cys nanoparticles induce ROS-dependent cell toxicity, and enhance chemo-radiation sensitivity of NSCLC cells in vivo and in vitro. Cancer letters\| PubMed ID: 29331422	2018
Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells. International journal of biological sciences\| PubMed ID: 29483839	2018
Racial disparities of differentiated thyroid carcinoma: clinical behavior, treatments, and long-term outcomes. World journal of surgical oncology\| PubMed ID: 29506526	2018
High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma. Human pathology\| PubMed ID: 29634976	2018
Bioinformatic analysis and identification of potential prognostic microRNAs and mRNAs in thyroid cancer. PeerJ\| PubMed ID: 29740512	2018
The role of radioactive iodine therapy in papillary thyroid cancer: an observational study based on SEER. OncoTargets and therapy\| PubMed ID: 29950860	2018
Impact of Gender and Age on the Prognosis of Differentiated Thyroid Carcinoma: a Retrospective Analysis Based on SEER. Hormones & cancer\| PubMed ID: 30014218	2018
β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors. International journal of oncology\| PubMed ID: 30132512	2018
Prognostic Genes of Breast Cancer Identified by Gene Co-expression Network Analysis. Frontiers in oncology\| PubMed ID: 30254986	2018
α-PD-L1 mAb enhances the abscopal effect of hypo-fractionated radiation by attenuating PD-L1 expression and inducing CD8 T-cell infiltration. Immunotherapy\| PubMed ID: 30511887	2019
Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation. Frontiers in oncology\| PubMed ID: 30533397	2018
Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice. Radiation research\| PubMed ID: 30694722	2019
Parathyroid autotransplantation at a novel site for better evaluation of the grafted gland function: study protocol for a prospective, randomized controlled trial. Trials\| PubMed ID: 30704522	2019
Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis. Frontiers in oncology\| PubMed ID: 31106147	2019
Evaluation of the association between the -1304T>G polymorphism in the promoter of the gene and the risk of colorectal cancer: a PRISMA-compliant meta-analysis. Annals of translational medicine\| PubMed ID: 31157265	2019
FePt/GO Nanosheets Suppress Proliferation, Enhance Radiosensitization and Induce Autophagy of Human Non-Small Cell Lung Cancer Cells. International journal of biological sciences\| PubMed ID: 31182920	2019
Radiotherapy activates autophagy to increase CD8 T cell infiltration by modulating major histocompatibility complex class-I expression in non-small cell lung cancer. The Journal of international medical research\| PubMed ID: 31187666	2019
Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer. Journal of cellular physiology\| PubMed ID: 31225658	2020
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway. Journal of Cancer\| PubMed ID: 31258730	2019
Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer. Journal of cancer research and clinical oncology\| PubMed ID: 31280346	2019
MiR-195 restrains lung adenocarcinoma by regulating CD4+ T cell activation via the CCDC88C/Wnt signaling pathway: a study based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GE... Annals of translational medicine\| PubMed ID: 31355230	2019
Mitochondria and Autophagy Dysfunction in Glucocorticoid-Induced Ocular Hypertension/Glaucoma Mice Model. Current eye research\| PubMed ID: 31425668	2020
A prognostic 10-lncRNA expression signature for predicting the risk of tumour recurrence in breast cancer patients. Journal of cellular and molecular medicine\| PubMed ID: 31429520	2019
A prognostic eight-lncRNA expression signature in predicting recurrence of ER-positive breast cancer receiving endocrine therapy. Journal of cellular physiology\| PubMed ID: 31663114	2020
A prognostic eight-gene expression signature for patients with breast cancer receiving adjuvant chemotherapy. Journal of cellular biochemistry\| PubMed ID: 31692061	2020
Different Role of Caveolin-1 Gene in the Progression of Gynecological Tumors. Asian Pacific journal of cancer prevention : APJCP\| PubMed ID: 31759347	2019
Recent Progress of Nanoscale Metal-Organic Frameworks in Cancer Theranostics and the Challenges of Their Clinical Application. International journal of nanomedicine\| PubMed ID: 32099352	2019
The prognostic value of tumor mutational burden and immune cell infiltration in esophageal cancer patients with or without radiotherapy. Aging\| PubMed ID: 32165590	2020
The characteristic of tumor immune microenvironment in pulmonary carcinosarcoma. Immunotherapy\| PubMed ID: 32212951	2020
Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration. International journal of biological sciences\| PubMed ID: 32226302	2020
Potential Prognostic Predictors and Molecular Targets for Skin Melanoma Screened by Weighted Gene Co-expression Network Analysis. Current gene therapy\| PubMed ID: 32416689	2020
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model. Stem cell research & therapy\| PubMed ID: 32456711	2020
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair. International journal of biological sciences\| PubMed ID: 32549761	2020
Immunomodulation of NK Cells by Ionizing Radiation. Frontiers in oncology\| PubMed ID: 32612950	2020
Establishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis. Cancer cell international\| PubMed ID: 32699529	2020
Retracted: Long non-coding RNA TP73-AS1 facilitates progression and radioresistance in lung cancer cells by the miR-216a-5p/CUL4B axis with exosome involvement. Thoracic cancer\| PubMed ID: 32841514	2021
Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma. Cancer medicine\| PubMed ID: 33098370	2020
Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis. Scientific reports\| PubMed ID: 33122682	2020
Pathologic evolution-related Gene Analysis based on both single-cell and bulk transcriptomics in Colorectal Cancer. Journal of Cancer\| PubMed ID: 33123277	2020
TRIM8 inhibits breast cancer proliferation by regulating estrogen signaling. American journal of cancer research\| PubMed ID: 33163282	2020
Systematic Profiling of Immune Risk Model to Predict Survival and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma. Frontiers in genetics\| PubMed ID: 33193693	2020
Establishment of the Prognostic Index Reflecting Tumor Immune Microenvironment of Lung Adenocarcinoma Based on Metabolism-Related Genes. Journal of Cancer\| PubMed ID: 33193873	2020
Establishment of Immune-related Gene Pair Signature to Predict Lung Adenocarcinoma Prognosis. Cell transplantation\| PubMed ID: 33334139	2020
Additional chemotherapy improves survival in stage II-III pulmonary sarcomatoid carcinoma patients undergoing surgery: a propensity scoring matching analysis. Annals of translational medicine\| PubMed ID: 33553317	2021
PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico\| PubMed ID: 33774805	2021
RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma. Cell & bioscience\| PubMed ID: 33858512	2021
MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer. International journal of biological sciences\| PubMed ID: 33994852	2021
Hollow PtCo alloy nanospheres as a high- and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer. Journal of materials chemistry. B\| PubMed ID: 34009230	2021
Immunological modulation of the Th1/Th2 shift by ionizing radiation in tumors (Review). International journal of oncology\| PubMed ID: 34109993	2021
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer. International journal of biological sciences\| PubMed ID: 34131401	2021
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization. Cancer medicine\| PubMed ID: 34152094	2021
MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity. International journal of biological sciences\| PubMed ID: 34326691	2021
Pitavastatin stimulates retinal angiogenesis via HMG-CoA reductase-independent activation of RhoA-mediated pathways and focal adhesion. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 34328550	2021
Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis. Journal of translational medicine\| PubMed ID: 34344410	2021
Comprehensive analysis reveals common DNA methylation patterns of tobacco-associated cancers: A pan-cancer analysis. Gene\| PubMed ID: 34400279	2021
Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review). International journal of oncology\| PubMed ID: 34558640	2021
Systematic Analyses of a Chemokine Family-Based Risk Model Predicting Clinical Outcome and Immunotherapy Response in Lung Adenocarcinoma. Cell transplantation\| PubMed ID: 34705571	2021
Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan. Frontiers in cellular and infection microbiology\| PubMed ID: 34869048	2021
Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10. Oxidative medicine and cellular longevity\| PubMed ID: 34925694	2021
The initial expression alterations occurring to transcription factors during the formation of breast cancer: Evidence from bioinformatics. Cancer medicine\| PubMed ID: 35037412	2022
Violations of proportional hazard assumption in Cox regression model of transcriptomic data in TCGA pan-cancer cohorts. Computational and structural biotechnology journal\| PubMed ID: 35070171	2022
Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells Increasing IL-6 Secretion Through PI3K/AKT Pathway. Frontiers in oncology\| PubMed ID: 35111682	2021
Frontline anti-PD-1/PD-L1 versus bevacizumab in advanced non-small-cell lung cancer: a network meta-analysis. Future oncology (London, England)\| PubMed ID: 35129371	2022
Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration. Journal of inflammation research\| PubMed ID: 35173457	2022
LncRNA PCAT1 activates SOX2 and suppresses radioimmune responses via regulating cGAS/STING signalling in non-small cell lung cancer. Clinical and translational medicine\| PubMed ID: 35415876	2022
Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy. Frontiers in immunology\| PubMed ID: 35493527	2022
Additional Postoperative Radiotherapy Prolonged the Survival of Patients with I-IIA Small Cell Lung Cancer: Analysis of the SEER Database. Journal of oncology\| PubMed ID: 35761902	2022
GPR87 promotes tumor cell invasion and mediates the immunogenomic landscape of lung adenocarcinoma. Communications biology\| PubMed ID: 35790819	2022
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer: Retraction. International journal of biological sciences\| PubMed ID: 35844800	2022
Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice. Metabolism: clinical and experimental\| PubMed ID: 35868524	2022
PARP inhibitor plus radiotherapy reshapes an inflamed tumor microenvironment that sensitizes small cell lung cancer to the anti-PD-1 immunotherapy. Cancer letters\| PubMed ID: 35926817	2022
Non-invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study. Clinical and translational medicine\| PubMed ID: 35968916	2022
Nanoscale Zeolitic Imidazolate Framework (ZIF)-8 in Cancer Theranostics: Current Challenges and Prospects. Cancers\| PubMed ID: 36010926	2022
Clinical outcomes of gefitinib and erlotinib in patients with NSCLC harboring uncommon EGFR mutations: A pooled analysis of 438 patients. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 36027855	2022
SETD2 regulates gene transcription patterns and is associated with radiosensitivity in lung adenocarcinoma. Frontiers in genetics\| PubMed ID: 36035179	2022
Correction: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma. Cell & bioscience\| PubMed ID: 36071531	2022
Exploration of Hub Genes in Retinopathy of Prematurity Based on Bioinformatics Analysis of the Oxygen-Induced Retinopathy Model. Journal of ophthalmology\| PubMed ID: 36124139	2022
Biomineralized Manganese Oxide Nanoparticles Synergistically Relieve Tumor Hypoxia and Activate Immune Response with Radiotherapy in Non-Small Cell Lung Cancer. Nanomaterials (Basel, Switzerland)\| PubMed ID: 36144927	2022
Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19. iScience\| PubMed ID: 36246577	2022
Ataxia telangiectasia mutated kinase inhibition promotes irradiation-induced PD-L1 expression in tumour-associated macrophages through IFN-I/JAK signalling pathway. Immunology\| PubMed ID: 36326481	2023
Erratum: MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity. International journal of biological sciences\| PubMed ID: 36439877	2022
Prediction of radiosensitivity and radiocurability using a novel supervised artificial neural network. BMC cancer\| PubMed ID: 36451111	2022
SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma. Journal of translational medicine\| PubMed ID: 36578072	2022
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors. PloS one\| PubMed ID: 36706151	2023
Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis. Frontiers in genetics\| PubMed ID: 36861126	2023
Editorial: Epigenetic regulation and non-histone post-translational modification in cancer. Frontiers in genetics\| PubMed ID: 37091796	2023
Clinical Outcomes of Afatinib Versus Osimertinib in Patients With Non-Small Cell Lung Cancer With Uncommon EGFR Mutations: A Pooled Analysis. The oncologist\| PubMed ID: 37116899	2023
SETD2 mediates immunotherapy and radiotherapy efficacy via regulating DNA damage responses and genomic stability in lung adenocarcinoma. Genes & diseases\| PubMed ID: 37223520	2023
Metabolomic Profiling of Long-Chain Polyunsaturated Fatty Acid Oxidation in Adults with Retinal Vein Occlusion: A Case-Control Study. The American journal of clinical nutrition\| PubMed ID: 37454758	2023
Identification of alternative splicing associated with clinical features: from pan-cancers to genitourinary tumors. Frontiers in oncology\| PubMed ID: 37810965	2023
Case Report: Genetic profiling of small intestine metastasis from poorly differentiated non-small cell lung cancer: report of 2 cases and literature review of the past 5 years. Frontiers in oncology\| PubMed ID: 38074661	2023
hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox. Genetic testing and molecular biomarkers\| PubMed ID: 38156905	2023
ω-3PUFAs Inhibit Hypoxia-Induced Retinal Neovascularization via Regulating Microglial Pyroptosis through METTL14-Mediated m6A Modification of IFNB1 mRNA. Applied biochemistry and biotechnology\| PubMed ID: 38175416	2024
Molecular classification reveals the sensitivity of lung adenocarcinoma to radiotherapy and immunotherapy: multi-omics clustering based on similarity network fusion. Cancer immunology, immunotherapy : CII\| PubMed ID: 38430394	2024
Pan-cell death-related signature reveals tumor immune microenvironment and optimizes personalized therapy alternations in lung adenocarcinoma. Scientific reports\| PubMed ID: 38977778	2024
UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation. Scientific reports\| PubMed ID: 39174635	2024
Targeting the LMP1-ALIX axis in EBV nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti-tumor immunity. Cancer communications (London, England)\| PubMed ID: 39402748	2024
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC-1α-mediated Transcriptional Coactivation. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 39498889	2024
Real-world effectiveness and safety of simnotrelvir/ritonavir for COVID-19: A nationwide, multicenter, prospective, observational cohort study in China. The Journal of infection\| PubMed ID: 39521253	2024
Expression of SIGLEC15 correlates with tumor immune infiltration, molecular subtypes, and breast cancer progression. PloS one\| PubMed ID: 39541298	2024
OncoSplicing 3.0: an updated database for identifying RBPs regulating alternative splicing events in cancers. Nucleic acids research\| PubMed ID: 39558172	2025
Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer. iScience\| PubMed ID: 39834867	2025
Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease. Nature communications\| PubMed ID: 40216741	2025
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity. Nature communications\| PubMed ID: 40379682	2025