separation-differential-characterization-gut-microbial-extracellular

Separation and Differential Characterization of Gut Microbial Extracellular Vesicles in Salt-Sensitive Rats under High-Salt Diet Conditions

High salt intake is a major risk factor for hypertension, and its underlying mechanism may be closely linked to extracellular vesicles (EVs) secreted by ...

Sichuan Province Orthopedic Hospital

Observational studies suggest physical activity (PA) enhances intelligence, while sedentary behavior (SB) poses a risk. However, causality remains unclear.

The causality of physical activity status and intelligence: A bidirectional Mendelian randomization study.

Low back pain (LBP) has been associated with education in previous observational studies, but the causality remains unclear. This study aims to assess the impact of education on LBP and to explore mediation by multiple lifestyle factors.

Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses.

The present study examined the effect of two dietary regimens with elevated salt concentrations (4% and 8% salt) on hemorheological functions of SD rats, and explored the underlying mechanisms mainly through microbiome-metabolome analysis. An 8% HSD substantially altered the hemorheological parameters, and compromised intestinal barrier integrity and reduced the short-chain fatty acid levels. The microbiome-metabolome analysis revealed that 49 genus-specific microorganisms and 156 metabolites showed a consistent trend after exposure to both 4% and 8% HSDs. Pathway analysis identified significant alterations in key metabolites within bile acid and arachidonic acid metabolism pathways. A two-sample Mendelian randomization (MR) analysis verified the link between high dietary salt intake and hemorheology. It also suggested that some key microbes and metabolites (such as _UCG-005, _NK4A136, _6, and _UCG-010, TXB-2, 11,12-diHETrE, glycochenodeoxycholate) may involve in abnormalities in blood rheology caused by high salt intake. Collectively, our findings underscored the adverse effects of high dietary salt on hemorheological functions and provide new insight into the underlying mechanism based on microbiome-metabolome analysis.

Article	Year
The causality of physical activity status and intelligence: A bidirectional Mendelian randomization study. PloS one\| PubMed ID: 37527259	2023
Smoking and BMI mediate the causal effect of education on lower back pain: observational and Mendelian randomization analyses. Frontiers in endocrinology\| PubMed ID: 38390198	2024
Microbiome-metabolome analysis insight into the effects of high-salt diet on hemorheological functions in SD rats. Frontiers in nutrition\| PubMed ID: 39381352	2024

Zhangmeng Xu

Biography

JoVE Journal Publications

Other Publications