Stephany Y. Tzeng

Department of Biomedical Engineering, Johns Hopkins University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis. Expert opinion on drug delivery\| PubMed ID: 21338327	2011
Non-viral gene delivery nanoparticles based on poly(Î²-amino esters) for treatment of glioblastoma. Biomaterials\| PubMed ID: 21536325	2011
Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells. International journal of nanomedicine\| PubMed ID: 22228998	2011
Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation. Biomaterials\| PubMed ID: 22871421	2012
Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer. Advanced healthcare materials\| PubMed ID: 23184674	2012
Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specifi... Journal of biomedical materials research. Part A\| PubMed ID: 23559534	2013
The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery. Journal of the American Chemical Society\| PubMed ID: 23570657	2013
A bioreducible linear poly(β-amino ester) for siRNA delivery. Chemical communications (Cambridge, England)\| PubMed ID: 23646347	2013
(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery. ACS applied materials & interfaces\| PubMed ID: 23755861	2013
Bioengineered nanoparticles for siRNA delivery. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 23821336	2013
Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells. ACS nano\| PubMed ID: 24673565	2014
Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo. ACS nano\| PubMed ID: 24766032	2014
Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA. Acta biomaterialia\| PubMed ID: 25246314	2015
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo. ACS nano\| PubMed ID: 25643235	2015
Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain. Biomaterials\| PubMed ID: 26828681	2016
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival. Biomaterials\| PubMed ID: 27240162	2016
Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy. Acta biomaterialia\| PubMed ID: 27262740	2016
Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection. Acta biomaterialia\| PubMed ID: 28344151	2017
Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing. Bioengineering & translational medicine\| PubMed ID: 28349127	2016
Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29784798	2018
The role of assembly parameters on polyplex poly(beta-amino ester) nanoparticle transfections. Biotechnology and bioengineering\| PubMed ID: 30636286	2019
Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo. Biomaterials\| PubMed ID: 31026613	2019
Polymeric Nucleic Acid Delivery for Immunoengineering. Current opinion in biomedical engineering\| PubMed ID: 31106282	2018
Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 31222852	2020
Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization. Acta biomaterialia\| PubMed ID: 31374338	2019
Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours. Nanoscale\| PubMed ID: 31612183	2019
In situ genetic engineering of tumors for long-lasting and systemic immunotherapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32034097	2020
Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction. Acta biomaterialia\| PubMed ID: 32522714	2020
Gene delivery for immunoengineering. Current opinion in biotechnology\| PubMed ID: 32554325	2020
Non-viral gene delivery of HIF-1α promotes angiogenesis in human adipose-derived stem cells. Acta biomaterialia\| PubMed ID: 32623098	2020
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities. Expert opinion on drug delivery\| PubMed ID: 32700581	2020
Suprachoroidal gene transfer with nonviral nanoparticles. Science advances\| PubMed ID: 32937452	2020
Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases. Cellular and molecular bioengineering\| PubMed ID: 33184574	2020
Efficiency of Cytosolic Delivery with Poly(β-amino ester) Nanoparticles is Dependent on the Effective p of the Polymer. ACS biomaterials science & engineering\| PubMed ID: 33463158	2020
Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenogra... ACS biomaterials science & engineering\| PubMed ID: 33463272	2020
Biodegradable Cationic Polymer Blends for Fabrication of Enhanced Artificial Antigen Presenting Cells to Treat Melanoma. ACS applied materials & interfaces\| PubMed ID: 33573372	2021
HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. The Journal of clinical investigation\| PubMed ID: 34128478	2021
Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy. Advanced functional materials\| PubMed ID: 34650390	2021
Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies. Advanced drug delivery reviews\| PubMed ID: 34715258	2021
High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA. Science advances\| PubMed ID: 34985952	2022
PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients. Science advances\| PubMed ID: 35235351	2022
ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization. JCI insight\| PubMed ID: 35653189	2022
Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma. Science advances\| PubMed ID: 35857843	2022
Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36508653	2022
Verteporfin-loaded microparticles for radiosensitization of preclinical lung and breast metastatic spine cancer. Journal of neurosurgery. Spine\| PubMed ID: 36585863	2023
Shape matters: Biodegradable anisotropic nanoparticle artificial antigen presenting cells for cancer immunotherapy. Acta biomaterialia\| PubMed ID: 36812956	2023
Anti-angiogenic collagen IV-derived peptide target engagement with αβ and αβ in ocular neovascularization models. iScience\| PubMed ID: 36844452	2023
Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles. ACS biomaterials science & engineering\| PubMed ID: 37233985	2023
Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis. Science advances\| PubMed ID: 37267370	2023
Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors. Biomaterials\| PubMed ID: 37290232	2023
Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 37339211	2023
Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses. Advanced therapeutics\| PubMed ID: 37743930	2023
Biomaterial-Mediated Genetic Reprogramming of Merkel Cell Carcinoma and Melanoma Leads to Targeted Cancer Cell Killing and . ACS biomaterials science & engineering\| PubMed ID: 37797944	2023
An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2. Cell reports. Medicine\| PubMed ID: 37992685	2023
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity. Nature biomedical engineering\| PubMed ID: 38082180	2024
Suprachoroidal gene transfer with nonviral nanoparticles in large animal eyes. Science advances\| PubMed ID: 38457512	2024
Phase 1, Dose Escalation, Nonrandomized, Open-Label, Clinical Trial Evaluating the Safety and Preliminary Efficacy of Allogenic Adipose-Derived Mesenchymal Stem Cells for Recurrent Glioblast... Neurosurgery practice\| PubMed ID: 38464470	2023
Supramolecular assembly of polycation/mRNA nanoparticles and in vivo monocyte programming. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 39172792	2024
Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs. Biomaterials\| PubMed ID: 39217793	2025
Alginate-based artificial antigen presenting cells expand functional CD8 T cells with memory characteristics for adoptive cell therapy. Biomaterials\| PubMed ID: 39217794	2025
Highly Multiplexed Immunofluorescence PhenoCycler Panel for Murine Formalin-Fixed Paraffin-Embedded Tissues Yields Insight Into Tumor Microenvironment Immunoengineering. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 39490742	2025
Therapeutic potential and impact of nanoengineered patient-derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma. Bioengineering & translational medicine\| PubMed ID: 39545093	2024
Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants. The Journal of biological chemistry\| PubMed ID: 39551135	2024
miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming. Cancers\| PubMed ID: 39796709	2024
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival. Signal transduction and targeted therapy\| PubMed ID: 40301302	2025