a-high-fidelity-porcine-model-orthotopic-heart-transplantation

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death

The number of advanced heart failure patients who can receive a heart transplant is limited by a shortage of suitable organ donors. In efforts to expand ...

an-evidence-based-echocardiographic-image-acquisition-protocol-for

An Evidence-Based Echocardiographic Image Acquisition Protocol for Evaluating Right Ventricular Function

A major risk factor for morbidity and mortality in critical illness is the presence of right ventricular dysfunction (RVD). However, characterizing and ...

Duke University Medical Center

Duke University Health System

The brain is extensively vascularized, useŝ20% of the body's oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild hypoxia, aged individuals appear to be even more sensitive. Aging is associated with progressive failure in pulmonary and cardiovascular systems, exposing the aged to both chronic and superimposed acute hypoxia. The HIF proteins, the "master regulators" of the cellular response to hypoxia, are robustly expressed in neurons and astrocytes. Astrocytes support neurons and synaptic plasticity via complex metabolic and trophic mechanisms. The activity of HIF proteins in the brain is diminished with aging, and the increased exposure to chronic and acute hypoxia with aging combined with diminished HIF activity may impair synaptic plasticity.

Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress.

This review aims to provide a concise overview of key recommendations, with a specific focus on common challenges faced by intraoperative echocardiographers when dealing with frequently encountered valvular pathologies and mechanical circulatory support. It offers valuable insights for medical practitioners in this field.

ArticleTotal : 2	Year
Publication title Cited by 2	2025
Publication title Cited by 1	2025

Article	Year
Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress. Hypoxia (Auckland, N.Z.)\| PubMed ID: 30519596	2018
Intraoperative Echocardiography: Guide to Decision-Making. Current cardiology reports\| PubMed ID: 38573554	2024

Michael Cutrone

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