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A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess

To develop a novel biomaterial with antibacterial properties for orthopedic surgical procedures, establishing an experimental animal model of ...

University of California, San Francisco (UCSF)

 A Care Bundle is proposed to prevent surgical site infections (SSIs). This study investigated SSI incidence and risk factors at our hospital, developed an SSI prevention Care Bundle, and tested its efficacy.  A retrospective review of 1,117 patients who underwent spinal surgical procedure under general anesthesia (January 2016-July 2023) was conducted. A total of 764 patients (mean age 69.7 y, 58.0% female) were included. SSI was diagnosed as per U.S. Centers for Disease Control and Prevention's guidelines. Risk factors evaluated included patient factors, operation-related factors, season, and Care Bundle implementation (introduced in April 2019). The Care Bundle included chlorhexidine gluconate bathing, skin disinfection, high-performance air purifier, glove changes, iodine-impregnated drapes, prophylactic antibiotic agents, and pre-operative sponge brushing.  SSI incidence was 2.6% (0.7% superficial, 1.9% deep), decreasing from 4.6% pre-Care Bundle to 1.0% post-implementation. Risk factors included smoking (p = 0.003), diabetes mellitus (p = 0.025), instrumentation (p = 0.039), posterior cervical operation (p = 0.049), and warm season (p = 0.024). Logistic regression identified Care Bundle implementation (odds ratio [OR] 0.27, p = 0.013), instrumentation (OR 3.59, p = 0.038), and warm season (OR 3.63, p = 0.025) as independent factors.  The Care Bundle effectively reduced SSI. Certain factors such as instrumentation and surgical procedures during warm seasons were associated with greater SSI rates.

Prevention of Surgical Site Infection after Spine Operation with Care Bundle.

Pelvic incidence (PI) is a fundamental parameter influencing sagittal spinal alignment. Recent studies indicate that PI is not a fixed value and may change after surgery for adult spinal deformity (ASD). However, research on this topic is very limited, and no consensus has been reached. The aim of this study is to assess postoperative PI changes in ASD patients and identify the factors influencing these changes with long-term follow-up.

Article	Year
Prevention of Surgical Site Infection after Spine Operation with Care Bundle. Surgical infections\| PubMed ID: 40384428	2025
Lower lumbar spine significantly affects the dynamics of pelvic incidence after corrective surgery for adult spinal deformity. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society\| PubMed ID: 40478254	2025

Mitsuhiro Nishizawa

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